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Peer-reviewedCC BYMuscles (Basel, Switzerland)

Creatine Supplementation in Crohn's Disease: Possible Therapeutic Trends in Symptoms and Muscle Tissue Integrity.

  • Konstantinos Papadimitriou1
  • Richard B Kreider2
  • Georgia-Eirini Deligiannidou1,3
  • Constantinos Giaginis4
  • Sousana K Papadopoulou1
4 affiliations
  1. 1Department of Nutritional Sciences and Dietetics, School of Health Sciences, International Hellenic University, 57001 Thessaloniki, Greece.
  2. 2Exercise & Sport Nutrition Lab, Human Clinical Research Facility, Department of Health & Kinesiology, Texas A&M University, College Station, TX 77843, USA.
  3. 3Laboratory of Hygiene and Environmental Protection, School of Medicine, Democritus University of Thrace, Dragana, 68100 Alexandroupolis, Greece.
  4. 4Department of Food Science and Nutrition, School of Environment, University of Aegean, 81100 Myrina, Greece.
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Abstract

Background/objectives

Creatine (Cr) supplementation may serve as a nutritional intervention, enhancing gut metabolism and preserving lean body mass, specifically fat-free mass, thereby improving functional capacity and quality of life in individuals with Crohn's disease (CD). This paper aims to explore the potential mechanisms through which Cr supplementation may influence CD patients and review the current literature on this topic.Results

Studies were analyzed to assess the relationship between Cr supplementation and CD. Preliminary evidence suggests potential therapeutic benefits, although data remain limited.Discussion

Cr supplementation warrants further investigation through clinical trials and cohort studies. Emerging data from both in vitro and in vivo models indicate creatine monohydrate (CrM) may constitute a biologically reasonable supportive strategy, requiring formal evaluation in clinical trials in patients with CD.Conclusions

As a foundational step, further analysis of National Health and Nutrition Examination Survey (NHANES) data to document Cr-rich food sources and daily intake patterns is recommended before initiating clinical trials in Crohn's disease cohorts.

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Cite

BibTeXRIS
BibTeX
@article{papadimitriou2026creatine,
  title = {{Creatine Supplementation in Crohn's Disease: Possible Therapeutic Trends in Symptoms and Muscle Tissue Integrity.}},
  author = {Konstantinos Papadimitriou and Richard B Kreider and Georgia-Eirini Deligiannidou and Constantinos Giaginis and Sousana K Papadopoulou},
  journal = {Muscles (Basel, Switzerland)},
  year = {2026},
  month = oct,
  doi = {10.3390/muscles5040071},
  url = {https://europepmc.org/article/MED/42924643},
  note = {CC BY},
}
RIS
TY  - JOUR
TI  - Creatine Supplementation in Crohn's Disease: Possible Therapeutic Trends in Symptoms and Muscle Tissue Integrity.
AU  - Konstantinos Papadimitriou
AU  - Richard B Kreider
AU  - Georgia-Eirini Deligiannidou
AU  - Constantinos Giaginis
AU  - Sousana K Papadopoulou
PY  - 2026
DA  - 2026/10/04
JO  - Muscles (Basel, Switzerland)
DO  - 10.3390/muscles5040071
UR  - https://europepmc.org/article/MED/42924643
AB  - Background/objectives  Creatine (Cr) supplementation may serve as a nutritional intervention, enhancing gut metabolism and preserving lean body mass, specifically fat-free mass, thereby improving functional capacity and quality of life in individuals with Crohn's disease (CD). This paper aims to explore the potential mechanisms through which Cr supplementation may influence CD patients and review the current literature on this topic.Results  Studies were analyzed to assess the relationship between Cr supplementation and CD. Preliminary evidence suggests potential therapeutic benefits, although data remain limited.Discussion  Cr supplementation warrants further investigation through clinical trials and cohort studies. Emerging data from both in vitro and in vivo models indicate creatine monohydrate (CrM) may constitute a biologically reasonable supportive strategy, requiring formal evaluation in clinical trials in patients with CD.Conclusions  As a foundational step, further analysis of National Health and Nutrition Examination Survey (NHANES) data to document Cr-rich food sources and daily intake patterns is recommended before initiating clinical trials in Crohn's disease cohorts.
SN  - 2813-0413
ER  -