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Peer-reviewedCC BYBMC Medical Imaging

Prenatal MRI quantitative analysis of the nonlinear morphological changes of the choroid plexus during the progression of fetal ventriculomegaly

  • Yuhan Zhang1
  • Fengwei Yu1
  • Meng Zeng1
  • Yan Li1
  • Li Zeng1
  • Chen Liu1
  • Ping Cai1
  • Xinwei Li2
  • Wei Chen1
  • Mingshan Du1
  1. 17T Magnetic Resonance Translational Medicine Research Center, Department of Radiology, Southwest Hospital, Army Medical University (Third Military Medical University)
  2. 2Chongqing Key Laboratory on Big Data for Bio Intelligence, Chongqing University of Posts and Telecommunications
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Abstract

Background To quantify fetal choroid plexus (CP) morphological changes across ventriculomegaly (VM) grades using routine 1.5-T MRI and assess their association with lateral ventricle dilatation. Methods In this retrospective study, 135 singleton fetuses (24–37 weeks’ gestation) were categorized by atrial width (AW): normal, mild VM, moderate VM, severe VM). On coronal T2-weighted images, CP length, width, perimeter, and area were measured. The two-dimensional (2D) CP ratio (CPR-2D) and CP-to-ventricle width ratio were calculated. Analysis of covariance (ANCOVA) adjusted for gestational age and fetal biometrics, and intraclass correlation coefficients (ICC) were used for analysis. Results Absolute CP measurements exhibited non-linear, stage-specific alterations: CP length and perimeter increased in mild VM, decreased in moderate VM, and increased again in severe VM. CP width progressively decreased until moderate VM before rebounding in severe cases. Conversely, ratio-based indices demonstrated a consistent, monotonic linear decrease as VM severity increased, which remained significant after adjusting for covariates (p < 0.05). While morphological asymmetry existed, the downward trend of ratios remained consistent for both ventricles. Conclusions The fetal CP undergoes a non-linear change process during the expansion of the lateral ventricle. However, based on ratio-based indicators, especially CPR-2D, stable and reproducible imaging biomarkers can be provided.

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Cite

BibTeXRIS
BibTeX
@article{zhang2026prenatal,
  title = {{Prenatal MRI quantitative analysis of the nonlinear morphological changes of the choroid plexus during the progression of fetal ventriculomegaly}},
  author = {Yuhan Zhang and Fengwei Yu and Meng Zeng and Yan Li and Li Zeng and Chen Liu and Ping Cai and Xinwei Li and Wei Chen and Mingshan Du},
  journal = {BMC Medical Imaging},
  year = {2026},
  month = jul,
  doi = {10.1186/s12880-026-02601-y},
  url = {https://doi.org/10.1186/s12880-026-02601-y},
  note = {CC BY},
}
RIS
TY  - JOUR
TI  - Prenatal MRI quantitative analysis of the nonlinear morphological changes of the choroid plexus during the progression of fetal ventriculomegaly
AU  - Yuhan Zhang
AU  - Fengwei Yu
AU  - Meng Zeng
AU  - Yan Li
AU  - Li Zeng
AU  - Chen Liu
AU  - Ping Cai
AU  - Xinwei Li
AU  - Wei Chen
AU  - Mingshan Du
PY  - 2026
DA  - 2026/07/01
JO  - BMC Medical Imaging
DO  - 10.1186/s12880-026-02601-y
UR  - https://doi.org/10.1186/s12880-026-02601-y
AB  - Background To quantify fetal choroid plexus (CP) morphological changes across ventriculomegaly (VM) grades using routine 1.5-T MRI and assess their association with lateral ventricle dilatation. Methods In this retrospective study, 135 singleton fetuses (24–37 weeks’ gestation) were categorized by atrial width (AW): normal, mild VM, moderate VM, severe VM). On coronal T2-weighted images, CP length, width, perimeter, and area were measured. The two-dimensional (2D) CP ratio (CPR-2D) and CP-to-ventricle width ratio were calculated. Analysis of covariance (ANCOVA) adjusted for gestational age and fetal biometrics, and intraclass correlation coefficients (ICC) were used for analysis. Results Absolute CP measurements exhibited non-linear, stage-specific alterations: CP length and perimeter increased in mild VM, decreased in moderate VM, and increased again in severe VM. CP width progressively decreased until moderate VM before rebounding in severe cases. Conversely, ratio-based indices demonstrated a consistent, monotonic linear decrease as VM severity increased, which remained significant after adjusting for covariates (p < 0.05). While morphological asymmetry existed, the downward trend of ratios remained consistent for both ventricles. Conclusions The fetal CP undergoes a non-linear change process during the expansion of the lateral ventricle. However, based on ratio-based indicators, especially CPR-2D, stable and reproducible imaging biomarkers can be provided.
SN  - 1471-2342
ER  -