Reversal of Chronic Stress‐Induced Inflammaging by Bazi Bushen Formula Through AMPK‐Sirtuins Axis Activation and Myeloid Reset
6 affiliations
- 1State Key Laboratory For Innovation and Transformation of Luobing Theory
- 2LC‐BIO Technologies CO., LTD.
- 3Nanjing University of Chinese Medicine
- 4Hebei Medical University
- 5Jinan University
- 6Tel Aviv University
Abstract
Chronic stress potentially accelerates aging and increases age‐related disease risk. However, the underlying mechanisms and organ specificity remain unclear. Utilizing a 12‐month unpredictable chronic mild stress (UCMS) mouse model, we revealed chronic stress significantly exacerbates systemic inflammation, causing widespread tissue damage and lifespan shortening. Integrated single‐cell RNA sequencing analysis of multiple tissues suggests a common feature of lymphocyte reduction and myeloid cell expansion. The lungs and kidneys exhibited pronounced stress responses, including epigenetic dysregulation and mitochondrial dysfunction. Both β‐nicotinamide mononucleotide (NMN) and compound medicine Bazi Bushen (BZBS) effectively alleviate the UCMS‐induced aging phenotypes. BZBS restores immune system homeostasis and reduces stress/inflammation levels in various tissues. Bioactive compounds from BZBS constituents—Schisandra chinensis (Turcz.) Baill. and Cnidium monnieri (L.) Cusson—improved mitochondrial function via AMPK‐SIRT‐PGC‐1α signaling activation. The present study underscores the importance of early intervention in chronic stress to prevent or delay age‐related diseases, with significant implications for public health strategies aimed at healthy aging.
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BibTeX
@article{li2026reversal,
title = {{Reversal of Chronic Stress‐Induced Inflammaging by Bazi Bushen Formula Through AMPK‐Sirtuins Axis Activation and Myeloid Reset}},
author = {Mengnan Li and Zheming Chen and Lu Wang and Zixuan Wang and Shixiong Zhang and Kunxu Niu and Xiaogang Shen and Xuan Lu and Runtao Zhang and Yuning Jiang and Yawen Li and Yi Dai and Xiyang Tang and Bin Hou and Min Shi and Xiaoya Wang and Zhifang Guo and Xingyu Xing and Ning Kang and Hongrong Li and Tianyu Kang and Evelyne Bischof and Yunlong Hou and Zhenhua Jia},
journal = {Exploration (Beijing, China)},
year = {2026},
month = oct,
doi = {10.1002/exp2.70235},
url = {https://europepmc.org/article/PMC/PMC13654189},
note = {CC BY},
}
RIS
TY - JOUR
TI - Reversal of Chronic Stress‐Induced Inflammaging by Bazi Bushen Formula Through AMPK‐Sirtuins Axis Activation and Myeloid Reset
AU - Mengnan Li
AU - Zheming Chen
AU - Lu Wang
AU - Zixuan Wang
AU - Shixiong Zhang
AU - Kunxu Niu
AU - Xiaogang Shen
AU - Xuan Lu
AU - Runtao Zhang
AU - Yuning Jiang
AU - Yawen Li
AU - Yi Dai
AU - Xiyang Tang
AU - Bin Hou
AU - Min Shi
AU - Xiaoya Wang
AU - Zhifang Guo
AU - Xingyu Xing
AU - Ning Kang
AU - Hongrong Li
AU - Tianyu Kang
AU - Evelyne Bischof
AU - Yunlong Hou
AU - Zhenhua Jia
PY - 2026
DA - 2026/10/11
JO - Exploration (Beijing, China)
DO - 10.1002/exp2.70235
UR - https://europepmc.org/article/PMC/PMC13654189
AB - Chronic stress potentially accelerates aging and increases age‐related disease risk. However, the underlying mechanisms and organ specificity remain unclear. Utilizing a 12‐month unpredictable chronic mild stress (UCMS) mouse model, we revealed chronic stress significantly exacerbates systemic inflammation, causing widespread tissue damage and lifespan shortening. Integrated single‐cell RNA sequencing analysis of multiple tissues suggests a common feature of lymphocyte reduction and myeloid cell expansion. The lungs and kidneys exhibited pronounced stress responses, including epigenetic dysregulation and mitochondrial dysfunction. Both β‐nicotinamide mononucleotide (NMN) and compound medicine Bazi Bushen (BZBS) effectively alleviate the UCMS‐induced aging phenotypes. BZBS restores immune system homeostasis and reduces stress/inflammation levels in various tissues. Bioactive compounds from BZBS constituents—Schisandra chinensis (Turcz.) Baill. and Cnidium monnieri (L.) Cusson—improved mitochondrial function via AMPK‐SIRT‐PGC‐1α signaling activation. The present study underscores the importance of early intervention in chronic stress to prevent or delay age‐related diseases, with significant implications for public health strategies aimed at healthy aging.
SN - 2766-8509
SN - 2766-2098
ER -