One night of closed-loop auditory stimulation during sleep enhances memory consolidation in patients with…

Abstract

INTRODUCTIONSleep-dependent memory consolidation is impaired early in Alzheimers disease (AD). Closed-loop auditory stimulation (CLAS) of sleep slow oscillations enhances memory consolidation in healthy individuals, but its efficacy in AD remains unknown.

METHODSWe conducted a randomized, double-blind, placebo-controlled crossover trial in 37 patients with biomarker-confirmed early symptomatic AD and an amnestic clinical phenotype. We assessed the effect of one night of CLAS, compared with one night of sham stimulation, on declarative memory retention, sleep electrophysiology, and sleep architecture.

RESULTSCLAS significantly improved overnight word-pair consolidation (Cohens dz = 0.42, p = 0.04), enhanced stimulation-evoked slow-wave and fast spindle activity, and preserved sleep architecture and subjective sleep quality.

DISCUSSIONThis study provides the first demonstration that CLAS modulates sleep electrophysiology and improves overnight memory consolidation in patients with biomarker-confirmed AD. Further studies need to address the sustainability of such effects with multi-night interventions for a clinically meaningful intervention.

Rhythmic auditory stimulation combined with split-belt treadmill training improves spatiotemporal gait parameters in hemiparetic stroke patients: a randomized controlled trial
Minghui Du, Wei Zhang, Liang Xia +5
Frontiers in Neurology14 Oct 2026Peer-reviewedCC BY 4.0Full textNeurologyCrossrefEurope PMCPMC
Enhancing deep sleep with auditory stimulation to boost cognitive training responsiveness in people with Parkinson's disease and mild cognitive impairment: Rationale and design of the double-blind randomized controlled trial PD-CogT-Sleep
A. Ophey, M. T. Kleinsorge, N. A. Wallimann +8
medRxiv2 Nov 2026PreprintAll rights reservedFull textNeurologymedRxiv
Effective stimulation sites and networks for substantia nigra pars reticulata deep brain stimulation for auditory verbal hallucinations in schizophrenia.
Min Jae Kim, Ankur Butala, Yousef Salimpour +7
Translational psychiatry1 Jul 2026Peer-reviewedCC BY-NC-NDFull text4 citedNeurologyEurope PMCDOAJ
Restoring mitochondrial redox balance enhances ribosome-associated quality control to mitigate Alzheimer’s disease pathology
Suman Rimal, Tejindar Pal Khaket, Wen Li +1
Communications Biology30 Sep 2026Peer-reviewedCC BY-NC-ND 4.0Full textPhysiologyCrossref
Optimized phase-targeted auditory stimulation reduces nocturnal spikes in childhood epilepsies
E. C. Schmidt, N.-A. Wapp, B. Alessandri +8
medRxiv6 Nov 2026PreprintCC BY-NCFull textNeurologymedRxiv

Cite

BibTeX RIS

BibTeX

@misc{lopezlarraz2026night,
  title = {{One night of closed-loop auditory stimulation during sleep enhances memory consolidation in patients with Alzheimer's Disease}},
  author = {E. Lopez-Larraz and D. Oriol and G. Fierro and E. Jubera-Garcia and J. G. Klinzing and M. Sierra-Torralba and E. Horna-Prat and C. Escolano and J. Sutil-Jimenez and F. Rojas and L. Montesano and C. Moreno Loscertales and G. Pinol and A. Pascual-Leone and E. Marta Moreno and E. Munoz-Farjas and J. Minguez},
  howpublished = {medRxiv},
  year = {2026},
  month = sep,
  doi = {10.64898/2026.09.14.26360893},
  url = {https://www.medrxiv.org/content/10.64898/2026.09.14.26360893v1},
  note = {CC BY-NC-ND},
}

RIS

TY  - UNPB
TI  - One night of closed-loop auditory stimulation during sleep enhances memory consolidation in patients with Alzheimer's Disease
AU  - E. Lopez-Larraz
AU  - D. Oriol
AU  - G. Fierro
AU  - E. Jubera-Garcia
AU  - J. G. Klinzing
AU  - M. Sierra-Torralba
AU  - E. Horna-Prat
AU  - C. Escolano
AU  - J. Sutil-Jimenez
AU  - F. Rojas
AU  - L. Montesano
AU  - C. Moreno Loscertales
AU  - G. Pinol
AU  - A. Pascual-Leone
AU  - E. Marta Moreno
AU  - E. Munoz-Farjas
AU  - J. Minguez
PY  - 2026
DA  - 2026/09/14
PB  - medRxiv
DO  - 10.64898/2026.09.14.26360893
UR  - https://www.medrxiv.org/content/10.64898/2026.09.14.26360893v1
AB  - INTRODUCTIONSleep-dependent memory consolidation is impaired early in Alzheimers disease (AD). Closed-loop auditory stimulation (CLAS) of sleep slow oscillations enhances memory consolidation in healthy individuals, but its efficacy in AD remains unknown.  METHODSWe conducted a randomized, double-blind, placebo-controlled crossover trial in 37 patients with biomarker-confirmed early symptomatic AD and an amnestic clinical phenotype. We assessed the effect of one night of CLAS, compared with one night of sham stimulation, on declarative memory retention, sleep electrophysiology, and sleep architecture.  RESULTSCLAS significantly improved overnight word-pair consolidation (Cohens dz = 0.42, p = 0.04), enhanced stimulation-evoked slow-wave and fast spindle activity, and preserved sleep architecture and subjective sleep quality.  DISCUSSIONThis study provides the first demonstration that CLAS modulates sleep electrophysiology and improves overnight memory consolidation in patients with biomarker-confirmed AD. Further studies need to address the sustainability of such effects with multi-night interventions for a clinically meaningful intervention.
ER  -

Abstract

Related

Cite