Factors associated with discharge on higher respiratory support for children with tracheostomy hospitalized with bacterial tracheostomy‐associated infections: A prospective, multicenter cohort study
10 affiliations
- 1Pediatric Pulmonary, Asthma, & Sleep Medicine, Stanford University Palo Alto California USA
- 2Population and Public Health Sciences, Keck School of Medicine University of Southern California Los Angeles California USA
- 3Pediatric Pulmonary and Sleep Medicine Seattle Children's Hospital Seattle Washington USA
- 4Pediatrics University of Pittsburgh Medical Center Pittsburgh Pennsylvania USA
- 5Infectious Diseases Children's National Medical Center Washington District of Columbia USA
- 6Pediatrics Children's National Medical Center Washington District of Columbia USA
- 7Pediatrics Johns Hopkins All Children's Hospital St. Petersburg Florida USA
- 8Pediatrics Cincinnati Children's Hospital Medical Center Cincinnati Ohio USA
- 9Pediatrics Stanford University Stanford California USA
- 10Pediatrics Children's Hospital Los Angeles Los Angeles California USA
Abstract
We conducted a multicenter prospective cohort study to identify factors associated with discharge on higher respiratory support in children with tracheostomy hospitalized for bacterial tracheostomy‐associated infections (bTRAINs). We included children 0–21 years with tracheostomy hospitalized for bTRAIN at six freestanding children's hospitals between 2020 and 2024. The primary outcome was discharge on higher respiratory support compared to pre‐hospital baseline. Generalized linear mixed‐effects regression models accounted for patient and hospital clustering. We included 641 children representing 1180 hospitalizations, with a median age of 5 years; 45.9% were female, 35.6% Hispanic, and 20.0% Non‐Hispanic Black. 24.7% were discharged on higher respiratory support. In adjusted analyses, discharge on higher respiratory support was associated with increased oxygen requirement, escalation of chronic ventilator settings, acute ventilatory support, and longer length of stay. In our study, discharge on higher respiratory support was driven by illness severity, rather than demographic or home support factors.
Related
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BibTeX
@article{jin2026factors,
title = {{Factors associated with discharge on higher respiratory support for children with tracheostomy hospitalized with bacterial tracheostomy‐associated infections: A prospective, multicenter cohort study}},
author = {Krystal S. Jin and Naoko Kono and Jonathan D. Cogen and Sarah Hofman DeYoung and Catherine S. Forster and Andrea Hahn and Margaret Rush and John M. Morrison and Joanna E. Thomson and Sukhada V. Mairal and Michael N. Neely and Wendy J. Mack and Tamara D. Simon and Christopher J. Russell},
journal = {Journal of Hospital Medicine},
year = {2026},
month = aug,
doi = {10.1002/jhm.70419},
url = {https://doi.org/10.1002/jhm.70419},
note = {CC BY-NC-ND 4.0},
}
RIS
TY - JOUR
TI - Factors associated with discharge on higher respiratory support for children with tracheostomy hospitalized with bacterial tracheostomy‐associated infections: A prospective, multicenter cohort study
AU - Krystal S. Jin
AU - Naoko Kono
AU - Jonathan D. Cogen
AU - Sarah Hofman DeYoung
AU - Catherine S. Forster
AU - Andrea Hahn
AU - Margaret Rush
AU - John M. Morrison
AU - Joanna E. Thomson
AU - Sukhada V. Mairal
AU - Michael N. Neely
AU - Wendy J. Mack
AU - Tamara D. Simon
AU - Christopher J. Russell
PY - 2026
DA - 2026/08/30
JO - Journal of Hospital Medicine
DO - 10.1002/jhm.70419
UR - https://doi.org/10.1002/jhm.70419
AB - We conducted a multicenter prospective cohort study to identify factors associated with discharge on higher respiratory support in children with tracheostomy hospitalized for bacterial tracheostomy‐associated infections (bTRAINs). We included children 0–21 years with tracheostomy hospitalized for bTRAIN at six freestanding children's hospitals between 2020 and 2024. The primary outcome was discharge on higher respiratory support compared to pre‐hospital baseline. Generalized linear mixed‐effects regression models accounted for patient and hospital clustering. We included 641 children representing 1180 hospitalizations, with a median age of 5 years; 45.9% were female, 35.6% Hispanic, and 20.0% Non‐Hispanic Black. 24.7% were discharged on higher respiratory support. In adjusted analyses, discharge on higher respiratory support was associated with increased oxygen requirement, escalation of chronic ventilator settings, acute ventilatory support, and longer length of stay. In our study, discharge on higher respiratory support was driven by illness severity, rather than demographic or home support factors.
SN - 1553-5592
SN - 1553-5606
ER -