Relationship between native papillary muscle T1 time and severity of functional mitral regurgitation in patients with non-ischemic dilated cardiomyopathy
Abstract
Background Functional mitral regurgitation is one of the severe complications of non-ischemic dilated cardiomyopathy (DCM). Non-contrast native T 1 mapping has emerged as a non-invasive method to evaluate myocardial fibrosis . We sought to evaluate the potential relationship between papillary muscle T 1 time and mitral regurgitation in DCM patients. Methods Forty DCM patients (55 ± 13 years) and 20 healthy adult control subjects (54 ± 13 years) were studied. Native T 1 mapping was performed using a slice interleaved T 1 mapping sequence (STONE) which enables acquisition of 5 slices in the short-axis plane within a 90 s free-breathing scan. We measured papillary muscle diameter, length and shortening. DCM patients were allocated into 2 groups based on the presence or absence of functional mitral regurgitation. Results Papillary muscle T 1 time was significantly elevated in DCM patients with mitral regurgitation ( n = 22) in comparison to those without mitral regurgitation ( n = 18) (anterior papillary muscle: 1127 ± 36 msec vs 1063 ± 16 msec, p < 0.05; posterior papillary muscle: 1124 ± 30 msec vs 1062 ± 19 msec, p < 0.05), but LV T 1 time was similar (1129 ± 38 msec vs 1134 ± 58 msec, p = 0.93). Multivariate linear regression analysis showed that papillary muscle native T 1 time (β = 0.10, 95 % CI: 0.05–0.17, p < 0.05) is significantly correlated with mitral regurgitant fraction . Elevated papillary muscle T 1 time was associated with larger diameter, longer length and decreased papillary muscle shortening (all p values <0.05). Conclusions In DCM, papillary muscle native T 1 time is significantly elevated and related to mitral regurgitant fraction.
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BibTeX
@article{kato2026relationship,
title = {{Relationship between native papillary muscle T1 time and severity of functional mitral regurgitation in patients with non-ischemic dilated cardiomyopathy}},
author = {Shingo Kato and Shiro Nakamori and Sébastien Roujol and Francesca Delling and Shadi Akhtari and Jihye Jang and Tamer Basha and Sophie Berg and Kraig Kissinger and Beth Goddu and Warren Manning and Reza Nezafat},
journal = {Journal of Cardiovascular Magnetic Resonance},
year = {2026},
month = oct,
doi = {10.1186/s12968-016-0301-y},
url = {https://hal.science/hal-05796056v1},
note = {CC BY},
}
RIS
TY - JOUR
TI - Relationship between native papillary muscle T1 time and severity of functional mitral regurgitation in patients with non-ischemic dilated cardiomyopathy
AU - Shingo Kato
AU - Shiro Nakamori
AU - Sébastien Roujol
AU - Francesca Delling
AU - Shadi Akhtari
AU - Jihye Jang
AU - Tamer Basha
AU - Sophie Berg
AU - Kraig Kissinger
AU - Beth Goddu
AU - Warren Manning
AU - Reza Nezafat
PY - 2026
DA - 2026/10/12
JO - Journal of Cardiovascular Magnetic Resonance
DO - 10.1186/s12968-016-0301-y
UR - https://hal.science/hal-05796056v1
AB - Background Functional mitral regurgitation is one of the severe complications of non-ischemic dilated cardiomyopathy (DCM). Non-contrast native T 1 mapping has emerged as a non-invasive method to evaluate myocardial fibrosis . We sought to evaluate the potential relationship between papillary muscle T 1 time and mitral regurgitation in DCM patients. Methods Forty DCM patients (55 ± 13 years) and 20 healthy adult control subjects (54 ± 13 years) were studied. Native T 1 mapping was performed using a slice interleaved T 1 mapping sequence (STONE) which enables acquisition of 5 slices in the short-axis plane within a 90 s free-breathing scan. We measured papillary muscle diameter, length and shortening. DCM patients were allocated into 2 groups based on the presence or absence of functional mitral regurgitation. Results Papillary muscle T 1 time was significantly elevated in DCM patients with mitral regurgitation ( n = 22) in comparison to those without mitral regurgitation ( n = 18) (anterior papillary muscle: 1127 ± 36 msec vs 1063 ± 16 msec, p < 0.05; posterior papillary muscle: 1124 ± 30 msec vs 1062 ± 19 msec, p < 0.05), but LV T 1 time was similar (1129 ± 38 msec vs 1134 ± 58 msec, p = 0.93). Multivariate linear regression analysis showed that papillary muscle native T 1 time (β = 0.10, 95 % CI: 0.05–0.17, p < 0.05) is significantly correlated with mitral regurgitant fraction . Elevated papillary muscle T 1 time was associated with larger diameter, longer length and decreased papillary muscle shortening (all p values <0.05). Conclusions In DCM, papillary muscle native T 1 time is significantly elevated and related to mitral regurgitant fraction.
SN - 1097-6647
SN - 1532-429X
ER -