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Peer-reviewedCC BY-NC-ND 4.0ACS Omega

MPDD: A Curated Database Bridging Membrane Protein-Drug-Disease Landscapes

  • Zongwei Lu1
  • Junhao Ma1
  • Jinpeng Yang1
  • Fan Wang1
  • Xiaolei Zhu1
  • Guangfu Yang1
  1. 1Central China Normal University , , ,
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Abstract

Membrane proteins (MPs) are vital drug targets, yet existing resources are fragmented across structural, pharmacological, and disease domains, limiting integrated exploration. To address this, we developed the Membrane Protein-Drug-Disease (MPDD) Database (https://chemyang.ccnu.edu.cn/ccb/server/MPDD/), a curated platform explicitly linking MPs, drugs, and diseases. MPDD currently includes 1523 MP targets, 589 diseases, and 18,489 drugs. It offers multi-dimensional query tools, interactive classification trees, drug property analysis, BLAST search, and co-target network visualization. By unifying the MP-drug-disease triad, MPDD aims to accelerate mechanistic studies, druggability evaluation, and targeted therapy discovery.

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Cite

BibTeXRIS
BibTeX
@article{lu2026mpdd,
  title = {{MPDD: A Curated Database Bridging Membrane Protein-Drug-Disease Landscapes}},
  author = {Zongwei Lu and Junhao Ma and Jinpeng Yang and Fan Wang and Xiaolei Zhu and Guangfu Yang},
  journal = {ACS Omega},
  year = {2026},
  month = oct,
  doi = {10.1021/acsomega.6c07804},
  url = {https://pubs.acs.org/acsodf/article/11/41/63734/5448160/MPDD-A-Curated-Database-Bridging-Membrane-Protein},
  note = {CC BY-NC-ND 4.0},
}
RIS
TY  - JOUR
TI  - MPDD: A Curated Database Bridging Membrane Protein-Drug-Disease Landscapes
AU  - Zongwei Lu
AU  - Junhao Ma
AU  - Jinpeng Yang
AU  - Fan Wang
AU  - Xiaolei Zhu
AU  - Guangfu Yang
PY  - 2026
DA  - 2026/10/09
JO  - ACS Omega
DO  - 10.1021/acsomega.6c07804
UR  - https://pubs.acs.org/acsodf/article/11/41/63734/5448160/MPDD-A-Curated-Database-Bridging-Membrane-Protein
AB  - Membrane proteins (MPs) are vital drug targets, yet existing resources are fragmented across structural, pharmacological, and disease domains, limiting integrated exploration. To address this, we developed the Membrane Protein-Drug-Disease (MPDD) Database (https://chemyang.ccnu.edu.cn/ccb/server/MPDD/), a curated platform explicitly linking MPs, drugs, and diseases. MPDD currently includes 1523 MP targets, 589 diseases, and 18,489 drugs. It offers multi-dimensional query tools, interactive classification trees, drug property analysis, BLAST search, and co-target network visualization. By unifying the MP-drug-disease triad, MPDD aims to accelerate mechanistic studies, druggability evaluation, and targeted therapy discovery.
SN  - 2470-1343
ER  -