Cidofovir-Induced Bilateral Uveitis, Hypotony and Choroidal Effusion: A Case Report.
- 1Department of Ophthalmology, University of Health Sciences, Gulhane Faculty of Medicine, Ankara, Türkiye.
Abstract
Cidofovir is an antiviral agent used in the treatment of viral infections but is associated with ocular toxicities. We report a case of a 71-year-old immunocompromised woman who developed bilateral anterior uveitis, marked hypotony, and choroidal effusion following intravenous cidofovir treatment for refractory herpes simplex virus type 2 infection. Ophthalmic examination and multimodal imaging, including optical coherence tomography and ocular ultrasonography, confirmed bilateral choroidal folds and effusion. Extensive systemic evaluation excluded infectious, inflammatory, and autoimmune etiologies. The close temporal relationship between cidofovir administration and symptom onset supported a diagnosis of cidofovir-induced ocular toxicity. Discontinuation of cidofovir and initiation of intensive topical corticosteroid therapy resulted in clinical improvement. This case highlights the importance of early recognition of cidofovir-related ocular adverse effects and the need for close ophthalmic monitoring during therapy.
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BibTeX
@article{cimen2026cidofovirinduced,
title = {{Cidofovir-Induced Bilateral Uveitis, Hypotony and Choroidal Effusion: A Case Report.}},
author = {Yasin Çimen and Habibullah Saltuk Songür and Mukaddes Kübra Uçar and Alper Can Yılmaz},
journal = {Beyoglu eye journal},
year = {2026},
month = oct,
doi = {10.14744/bej.2026.77528},
url = {https://europepmc.org/article/MED/42898503},
note = {CC BY-NC},
}
RIS
TY - JOUR
TI - Cidofovir-Induced Bilateral Uveitis, Hypotony and Choroidal Effusion: A Case Report.
AU - Yasin Çimen
AU - Habibullah Saltuk Songür
AU - Mukaddes Kübra Uçar
AU - Alper Can Yılmaz
PY - 2026
DA - 2026/10/01
JO - Beyoglu eye journal
DO - 10.14744/bej.2026.77528
UR - https://europepmc.org/article/MED/42898503
AB - Cidofovir is an antiviral agent used in the treatment of viral infections but is associated with ocular toxicities. We report a case of a 71-year-old immunocompromised woman who developed bilateral anterior uveitis, marked hypotony, and choroidal effusion following intravenous cidofovir treatment for refractory herpes simplex virus type 2 infection. Ophthalmic examination and multimodal imaging, including optical coherence tomography and ocular ultrasonography, confirmed bilateral choroidal folds and effusion. Extensive systemic evaluation excluded infectious, inflammatory, and autoimmune etiologies. The close temporal relationship between cidofovir administration and symptom onset supported a diagnosis of cidofovir-induced ocular toxicity. Discontinuation of cidofovir and initiation of intensive topical corticosteroid therapy resulted in clinical improvement. This case highlights the importance of early recognition of cidofovir-related ocular adverse effects and the need for close ophthalmic monitoring during therapy.
SN - 2459-1777
SN - 2587-0394
ER -