Curvature-induced migration of small domains on lipid membranes
Abstract
Membrane curvature has been shown to bias the location of lipid or protein domains, but the roles of bending rigidity, spontaneous curvature, Gaussian bending modulus, and line tension are difficult to separate in general. We develop a small-domain description for a membrane whose shape is held fixed, e.g. by strong adhesion to a curved substrate. Combining a local Helfrich energy with the small-area isoperimetric expansion gives a position-dependent energy determined by the local mean and Gaussian curvatures. We identify four generic regimes of curvature preference whose boundaries depend on only two dimensionless parameters. On specific membrane shapes with complex curvature, we show that this curvature preference determines the energy landscapes experienced by small domains, which are strongly dependent on the size of the domain through the line tension contribution. For example, on an oblate-shaped membrane, very small domains tend to localize at the poles, whereas larger domains prefer to localize at the equator. Whether this transition is continuous or discontinuous is found to strongly depend on the spontaneous curvature of the domain. This ordering suggests a mechanism by which small domains can collect and coalesce at one location before relocating as they grow.
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BibTeX
@misc{agudocanalejo2026curvatureinduced,
title = {{Curvature-induced migration of small domains on lipid membranes}},
author = {Jaime Agudo-Canalejo},
howpublished = {arXiv},
year = {2026},
month = sep,
doi = {10.48550/arxiv.2609.39772},
eprint = {2609.39772},
archivePrefix = {arXiv},
url = {https://arxiv.org/abs/2609.39772},
}
RIS
TY - UNPB
TI - Curvature-induced migration of small domains on lipid membranes
AU - Jaime Agudo-Canalejo
PY - 2026
DA - 2026/09/30
PB - arXiv
DO - 10.48550/arxiv.2609.39772
UR - https://arxiv.org/abs/2609.39772
AB - Membrane curvature has been shown to bias the location of lipid or protein domains, but the roles of bending rigidity, spontaneous curvature, Gaussian bending modulus, and line tension are difficult to separate in general. We develop a small-domain description for a membrane whose shape is held fixed, e.g. by strong adhesion to a curved substrate. Combining a local Helfrich energy with the small-area isoperimetric expansion gives a position-dependent energy determined by the local mean and Gaussian curvatures. We identify four generic regimes of curvature preference whose boundaries depend on only two dimensionless parameters. On specific membrane shapes with complex curvature, we show that this curvature preference determines the energy landscapes experienced by small domains, which are strongly dependent on the size of the domain through the line tension contribution. For example, on an oblate-shaped membrane, very small domains tend to localize at the poles, whereas larger domains prefer to localize at the equator. Whether this transition is continuous or discontinuous is found to strongly depend on the spontaneous curvature of the domain. This ordering suggests a mechanism by which small domains can collect and coalesce at one location before relocating as they grow.
ER -