Association between mean platelet volume and acute cholecystitis in pregnant patients with right upper quadrant pain: A multicenter retrospective cohort study.
5 affiliations
- 1Department of General Surgery, Etlik City Hospital, Ankara-Türkiye.
- 2Department of General Surgery, Muş State Hospital, Muş-Türkiye.
- 3Department of General Surgery, Atatürk University Faculty of Medicine, Erzurum-Türkiye.
- 4Department of Obstetrics and Gynecology, Etlik City Hospital, Ankara-Türkiye.
- 5Department of Obstetrics and Gynecology, Van Training and Research Hospital, Van-Türkiye.
Abstract
Background
Physiological and hematological changes during pregnancy may complicate the interpretation of conventional inflammatory markers in patients with suspected acute cholecystitis (AC). This study aimed to evaluate the association between mean platelet volume (MPV), derived from routine complete blood count analysis, and AC in pregnant patients and to investigate whether this association remained consistent across pregnancy trimesters.Methods
This retrospective multicenter exploratory cohort study included 112 pregnant patients presenting with right upper quadrant pain between 2022 and 2025. According to retrospective classification based on the Tokyo Guidelines 2018 criteria, 89 patients were classified as AC and 23 as non-cholecystitis (NC). MPV and other hematological parameters were compared between the groups. Logistic regression analysis adjusted for pregnancy trimester was performed to evaluate the association between MPV and AC. Receiver operating characteristic (ROC) curve analysis with confidence intervals (CIs) was performed to assess the exploratory discriminative performance of MPV.Results
MPV levels were significantly higher in the AC group than in the NC group (10.6 fL vs. 10.3 fL, p=0.034). In univariable logistic regression analysis, MPV was significantly associated with AC (odds ratio [OR]: 1.734, 95% CI: 1.203-2.500, p=0.003), and this association remained significant after adjustment for pregnancy trimester (OR: 1.870, 95% CI: 1.251-2.794, p=0.002). No significant associations were observed for white blood cell, neutrophil-to-lymphocyte ratio, platelet count, or platelet-to-lymphocyte ratio. ROC analysis demonstrated limited discriminative performance for MPV (area under the curve: 0.655). At the identified cut-off value of 8.70 fL, sensitivity was 95.2% and specificity was 36.4%.Conclusion
MPV was significantly associated with AC in pregnant patients; however, its limited discriminative performance and low specificity suggest that it should not be used as an independent diagnostic marker. MPV may provide supportive diagnostic value when interpreted together with clinical and ultrasonographic findings. Larger prospective studies including standardized MPV measurements and pregnancy-specific diagnostic frameworks are needed to better define the diagnostic role of MPV in pregnant patients with suspected AC.
Related
- Association of platelet-rich plasma combined with dorsal root ganglion-targeted pulsed radiofrequency with outcomes in subacute thoracic herpes zoster neuralgia: a retrospective cohort study
- An Early Longitudinal Decrease in Platelet Count Is Associated With Poor Prognosis in Acute Myocardial Infarction Patients: A Multicenter Retrospective Study.
- Association between postoperative serum calcium and complications after pancreaticoduodenectomy in a retrospective multicenter study
- Association of Serum Ferritin and Cytokine Profile With Severity of Acute Cholecystitis in Patients Undergoing Laparoscopic Cholecystectomy
- Association between medial meniscus extrusion and joint effusion persistence at 1 month in knee osteoarthritis: a multicenter retrospective cohort study.
BibTeX
@article{bayar2026association,
title = {{Association between mean platelet volume and acute cholecystitis in pregnant patients with right upper quadrant pain: A multicenter retrospective cohort study.}},
author = {Bahattin Bayar and Ugurcan Bulut and Bilal Aydın and Abdulkadir Aktepe and Ahmet Alperen Yigitbasi and Sevinç Çetin and Feyza Savaş and Caganay Soysal and Rıfat Peksoz},
journal = {Ulusal travma ve acil cerrahi dergisi = Turkish journal of trauma \& emergency surgery : TJTES},
year = {2026},
month = oct,
doi = {10.14744/tjtes.2026.43505},
url = {https://europepmc.org/article/MED/42841892},
note = {CC BY-NC},
}
RIS
TY - JOUR
TI - Association between mean platelet volume and acute cholecystitis in pregnant patients with right upper quadrant pain: A multicenter retrospective cohort study.
AU - Bahattin Bayar
AU - Ugurcan Bulut
AU - Bilal Aydın
AU - Abdulkadir Aktepe
AU - Ahmet Alperen Yigitbasi
AU - Sevinç Çetin
AU - Feyza Savaş
AU - Caganay Soysal
AU - Rıfat Peksoz
PY - 2026
DA - 2026/10/01
JO - Ulusal travma ve acil cerrahi dergisi = Turkish journal of trauma & emergency surgery : TJTES
DO - 10.14744/tjtes.2026.43505
UR - https://europepmc.org/article/MED/42841892
AB - Background Physiological and hematological changes during pregnancy may complicate the interpretation of conventional inflammatory markers in patients with suspected acute cholecystitis (AC). This study aimed to evaluate the association between mean platelet volume (MPV), derived from routine complete blood count analysis, and AC in pregnant patients and to investigate whether this association remained consistent across pregnancy trimesters.Methods This retrospective multicenter exploratory cohort study included 112 pregnant patients presenting with right upper quadrant pain between 2022 and 2025. According to retrospective classification based on the Tokyo Guidelines 2018 criteria, 89 patients were classified as AC and 23 as non-cholecystitis (NC). MPV and other hematological parameters were compared between the groups. Logistic regression analysis adjusted for pregnancy trimester was performed to evaluate the association between MPV and AC. Receiver operating characteristic (ROC) curve analysis with confidence intervals (CIs) was performed to assess the exploratory discriminative performance of MPV.Results MPV levels were significantly higher in the AC group than in the NC group (10.6 fL vs. 10.3 fL, p=0.034). In univariable logistic regression analysis, MPV was significantly associated with AC (odds ratio [OR]: 1.734, 95% CI: 1.203-2.500, p=0.003), and this association remained significant after adjustment for pregnancy trimester (OR: 1.870, 95% CI: 1.251-2.794, p=0.002). No significant associations were observed for white blood cell, neutrophil-to-lymphocyte ratio, platelet count, or platelet-to-lymphocyte ratio. ROC analysis demonstrated limited discriminative performance for MPV (area under the curve: 0.655). At the identified cut-off value of 8.70 fL, sensitivity was 95.2% and specificity was 36.4%.Conclusion MPV was significantly associated with AC in pregnant patients; however, its limited discriminative performance and low specificity suggest that it should not be used as an independent diagnostic marker. MPV may provide supportive diagnostic value when interpreted together with clinical and ultrasonographic findings. Larger prospective studies including standardized MPV measurements and pregnancy-specific diagnostic frameworks are needed to better define the diagnostic role of MPV in pregnant patients with suspected AC.
SN - 1306-696X
SN - 1307-7945
ER -