Prevalence, predictive factors, and the influential role of physical activity trajectories of cancer-related cognitive impairment among patients newly diagnosed with non-small cell lung cancer.
7 affiliations
- 1School of Nursing, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong SAR.
- 2Australian Research Centre for Cancer Survivorship, Faculty of Medicine and Health, University of New South Wales, Sydney, NSW, Australia.
- 3Graduate Institute of Athletics and Coaching Science, National Taiwan Sport University, Taoyuan, Taiwan.
- 4Department of Clinical Oncology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong SAR.
- 5School of Nursing, Faculty of Health and Social Sciences, The Hong Kong Polytechnic University, Hung Hom, Hong Kong SAR.
- 6School of Nursing, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong SAR. [email protected].
- 7Alice Ho Miu Ling Nethersole Charity Foundation Professor in Nursing, Pokfulam, Hong Kong SAR. [email protected].
Abstract
Purpose
Evidence on the prevalence, trajectory, and predictors of cancer-related cognitive impairment (CRCI) in newly diagnosed non-small cell lung cancer (NSCLC) patients remains limited, particularly regarding the role of physical activity patterns. This study aimed to estimate the prevalence of CRCI, assess changes in objective and subjective cognitive functions, and identify predictors of CRCI, focusing on physical activity trajectories among patients newly diagnosed with NSCLC in Hong Kong.Methods
A prospective observational study was conducted with 327 NSCLC patients newly diagnosed within 4 weeks. Cognitive function was objectively assessed using the HK-MoCA 5-Minute Protocol and subjectively measured using the FACT-Cog scale at baseline and monthly for six months. Physical activity patterns were analyzed through group-based trajectory modelling. Multivariate logistic regression identified predictors of CRCI, adjusting for demographic and clinical factors.Results
The prevalence of objective CRCI ranged from 17.5% to 29.1% over the 6-month period, with 24.1% affected at 6 months. Three distinct physical activity trajectories emerged: consistently low (43.1%), consistently high (11.9%), and declining from high to moderate activity (45%). Both consistently high and declining physical activity trajectories were associated with a significantly reduced CRCI risk (93.8% and 85.9% lower risk, respectively) compared to the consistently low activity group. Consistently high physical activity trajectories were also correlated with better objective and subjective cognitive performance. Additional predictors of CRCI included lower baseline perceived cognitive function and self-efficacy for exercise.Conclusion
This study provides novel evidence that physical activity trajectories are associated with CRCI in newly diagnosed lung cancer patients.
Related
- Prediction of cognitive impairment in Parkinson’s disease using TabPFN: an integrative analysis of clinical data, longitudinal trajectories, and lipidomics
- Executive dysfunction in COPD: prevalence and clinical correlates of cognitive impairment : A cross-sectional case–control study
- Association between PCSK9 and post-stroke cognitive impairment: a retrospective cohort study and predictive models establishment based on machine learning.
- Machine learning based digital assessment of mild cognitive impairment using mouse trajectories during the trail making test
- Prevalence and pattern of cognitive impairment among neurological outpatients in Kano, Nigeria: a cross-sectional study.
BibTeX
@article{ho2026prevalence,
title = {{Prevalence, predictive factors, and the influential role of physical activity trajectories of cancer-related cognitive impairment among patients newly diagnosed with non-small cell lung cancer.}},
author = {Mu-Hsing Ho and Janette L Vardy and Yen-Kuang Lin and Wing Lok Chan and Naomi Takemura and Lizhen Wang and Denise Shuk Ting Cheung and Chia-Chin Lin},
journal = {Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer},
year = {2026},
month = oct,
doi = {10.1007/s00520-026-11368-5},
url = {https://europepmc.org/article/MED/42925312},
note = {CC BY},
}
RIS
TY - JOUR
TI - Prevalence, predictive factors, and the influential role of physical activity trajectories of cancer-related cognitive impairment among patients newly diagnosed with non-small cell lung cancer.
AU - Mu-Hsing Ho
AU - Janette L Vardy
AU - Yen-Kuang Lin
AU - Wing Lok Chan
AU - Naomi Takemura
AU - Lizhen Wang
AU - Denise Shuk Ting Cheung
AU - Chia-Chin Lin
PY - 2026
DA - 2026/10/24
JO - Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer
DO - 10.1007/s00520-026-11368-5
UR - https://europepmc.org/article/MED/42925312
AB - Purpose Evidence on the prevalence, trajectory, and predictors of cancer-related cognitive impairment (CRCI) in newly diagnosed non-small cell lung cancer (NSCLC) patients remains limited, particularly regarding the role of physical activity patterns. This study aimed to estimate the prevalence of CRCI, assess changes in objective and subjective cognitive functions, and identify predictors of CRCI, focusing on physical activity trajectories among patients newly diagnosed with NSCLC in Hong Kong.Methods A prospective observational study was conducted with 327 NSCLC patients newly diagnosed within 4 weeks. Cognitive function was objectively assessed using the HK-MoCA 5-Minute Protocol and subjectively measured using the FACT-Cog scale at baseline and monthly for six months. Physical activity patterns were analyzed through group-based trajectory modelling. Multivariate logistic regression identified predictors of CRCI, adjusting for demographic and clinical factors.Results The prevalence of objective CRCI ranged from 17.5% to 29.1% over the 6-month period, with 24.1% affected at 6 months. Three distinct physical activity trajectories emerged: consistently low (43.1%), consistently high (11.9%), and declining from high to moderate activity (45%). Both consistently high and declining physical activity trajectories were associated with a significantly reduced CRCI risk (93.8% and 85.9% lower risk, respectively) compared to the consistently low activity group. Consistently high physical activity trajectories were also correlated with better objective and subjective cognitive performance. Additional predictors of CRCI included lower baseline perceived cognitive function and self-efficacy for exercise.Conclusion This study provides novel evidence that physical activity trajectories are associated with CRCI in newly diagnosed lung cancer patients.
SN - 0941-4355
SN - 1433-7339
ER -