Trends in mortality involving co-reported arrhythmia and dyslipidemia, 1999–2023: A Centers for Disease Control and Prevention Wide-ranging Online Data for Epidemiologic Research analysis with exploratory projections to 2035
10 affiliations
- 1Department of Medicine, Harlingen Medical Center, USA
- 2Department of Medicine, King Edward Medical University, Pakistan
- 3Department of Medicine, Nishtar Medical University, Pakistan
- 4Department of Medicine, Ameer-ud-Din Medical College, Pakistan
- 5Department of Medicine, Jinnah Sindh Medical University, Pakistan
- 6Department of Medicine, Rawalpindi Medical University, Pakistan
- 7Department of Medicine, Dow University of Health Sciences, Pakistan
- 8Department of Medicine, Mercy Health Fairfield Hospital, USA
- 9Department of Medicine, International University of Kyrgyzstan (ISM), Kyrgyzstan
- 10Department of Medicine, Kabul Medical University, Afghanistan
Abstract
Objective: Emerging evidence links dyslipidemia to cardiac structural and electrical remodeling. This study examined national trends in mortality involving co-reported arrhythmia and dyslipidemia among US adults aged ≥65 years from 1999 to 2023 and provided exploratory projections through 2035.
Methods: This retrospective, observational, population-based study used death-certificate data from the Centers for Disease Control and Prevention Wide-ranging Online Data for Epidemiologic Research multiple-cause mortality database. Deaths among adults aged ≥65 years listing arrhythmia (International Classification of Diseases and Related Health Problems, 10th revision: I44.0–I44.7, I45.0–I45.9, I47.0–I47.9, I48, and I49.0–I49.9) and dyslipidemia (E78) among multiple causes were included. Age-adjusted mortality rates per 100,000 were calculated and stratified by sex, race/ethnicity, census region, and urban–rural status. Joinpoint regression was used to calculate annual percentage changes. An exploratory autoregressive integrated moving average model projected rates through 2035.
Results: A total of 246,710 deaths involving co-reported arrhythmia and dyslipidemia occurred between 1999 and 2023. The age-adjusted mortality rate increased from 4.96 (1999) to 47.9 (2023) per 100,000. The largest increase occurred between 2018 and 2021 (annual percentage change: 17.88%; 95% confidence interval: 14.79 to 21.04). An exploratory autoregressive integrated moving average model projected the age-adjusted mortality rate to reach 68.54 (95% prediction interval: 49.85–87.24) by 2035. Higher rates were observed in males, non-Hispanic White individuals, South and West regions, and nonmetropolitan areas.
Conclusions: Mortality involving co-reported arrhythmia and dyslipidemia among older US adults increased substantially over 25 years with persistent demographic and geographic disparities. These findings highlight the need for continued surveillance and research into contributing factors.
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BibTeX
@article{khan2026trends,
title = {{Trends in mortality involving co-reported arrhythmia and dyslipidemia, 1999–2023: A Centers for Disease Control and Prevention Wide-ranging Online Data for Epidemiologic Research analysis with exploratory projections to 2035}},
author = {Muhammad Huzaifa Ahmed Khan and Awon Muhammad and Ahtisham Khatab and Sheraz Qasim and Javeria Javed and Azooba Khalid and Marium Fawad and Muhammad Omer Khalid and Shameer Iqbal Ghuman and Muhammad Ahsan and Sifat Ullah Safi and Muneeb Khawar},
journal = {The Journal of International Medical Research},
year = {2026},
month = sep,
doi = {10.1177/03000605261488122},
url = {https://doi.org/10.1177/03000605261488122},
note = {CC BY-NC 4.0},
}
RIS
TY - JOUR
TI - Trends in mortality involving co-reported arrhythmia and dyslipidemia, 1999–2023: A Centers for Disease Control and Prevention Wide-ranging Online Data for Epidemiologic Research analysis with exploratory projections to 2035
AU - Muhammad Huzaifa Ahmed Khan
AU - Awon Muhammad
AU - Ahtisham Khatab
AU - Sheraz Qasim
AU - Javeria Javed
AU - Azooba Khalid
AU - Marium Fawad
AU - Muhammad Omer Khalid
AU - Shameer Iqbal Ghuman
AU - Muhammad Ahsan
AU - Sifat Ullah Safi
AU - Muneeb Khawar
PY - 2026
DA - 2026/09/16
JO - The Journal of International Medical Research
DO - 10.1177/03000605261488122
UR - https://doi.org/10.1177/03000605261488122
AB - Objective: Emerging evidence links dyslipidemia to cardiac structural and electrical remodeling. This study examined national trends in mortality involving co-reported arrhythmia and dyslipidemia among US adults aged ≥65 years from 1999 to 2023 and provided exploratory projections through 2035. Methods: This retrospective, observational, population-based study used death-certificate data from the Centers for Disease Control and Prevention Wide-ranging Online Data for Epidemiologic Research multiple-cause mortality database. Deaths among adults aged ≥65 years listing arrhythmia (International Classification of Diseases and Related Health Problems, 10th revision: I44.0–I44.7, I45.0–I45.9, I47.0–I47.9, I48, and I49.0–I49.9) and dyslipidemia (E78) among multiple causes were included. Age-adjusted mortality rates per 100,000 were calculated and stratified by sex, race/ethnicity, census region, and urban–rural status. Joinpoint regression was used to calculate annual percentage changes. An exploratory autoregressive integrated moving average model projected rates through 2035. Results: A total of 246,710 deaths involving co-reported arrhythmia and dyslipidemia occurred between 1999 and 2023. The age-adjusted mortality rate increased from 4.96 (1999) to 47.9 (2023) per 100,000. The largest increase occurred between 2018 and 2021 (annual percentage change: 17.88%; 95% confidence interval: 14.79 to 21.04). An exploratory autoregressive integrated moving average model projected the age-adjusted mortality rate to reach 68.54 (95% prediction interval: 49.85–87.24) by 2035. Higher rates were observed in males, non-Hispanic White individuals, South and West regions, and nonmetropolitan areas. Conclusions: Mortality involving co-reported arrhythmia and dyslipidemia among older US adults increased substantially over 25 years with persistent demographic and geographic disparities. These findings highlight the need for continued surveillance and research into contributing factors.
SN - 0300-0605
SN - 1473-2300
ER -