Retina status at first ROP exam and the subsequent development of type 1 ROP
- 1Department of Ophthalmology, University of Colorado School of Medicine, Aurora, CO 80045, USA
- 2Department of Pediatric Ophthalmology, Children's Hospital Colorado, Aurora, CO 80045, USA
Abstract
AIM: To evaluate the association between findings at the first retinopathy of prematurity (ROP) exam and the subsequent development of type 1 ROP in a large registry of infants. METHODS: A retrospective cohort study of the records of infants (n=1582) screened for ROP (2013–2022) was conducted using an ROP registry. Logistic regression using generalized estimating equations was used to estimate odds ratios (OR) and 95% confidence intervals (CI) of developing type 1 ROP following any ROP at initial exam, or for infants who required a one-week follow-up exam following initial exam. RESULTS: Gestational age at delivery of 1582 infants (834 males) were 28.8±2.5wk. Infants with any ROP noted at initial exam had increased odds of developing type 1 ROP [OR=3.64, 95%CI (1.93, 6.88), P<0.001] compared to infants without any ROP noted at initial exam. Infants who required a one-week follow-up exam for any reason after initial ROP exam had even higher odds of developing type 1 ROP [OR=9.31, 95%CI (5.63, 15.4), P<0.001] compared to infants who did not require a one-week follow-up exam. CONCLUSION: Infants with ROP noted at initial exam and infants requiring a one-week follow-up exam are significantly more likely to develop type 1 ROP. When signs of ROP or concern for ROP are noted by the ophthalmologist at the first ROP exam, there is a significant increase in the likelihood of developing type 1 ROP. These data will assist ophthalmologists in informing families and neonatologists of the risk of ROP from the onset of ROP exams.
Related
- Emergency Department Length of Stay, Employment Status, and Subsequent Risk of Hospitalisation: A survival analysis of linked administrative records in England
- Prognostic Language and Subsequent Code-Status Limitation After Acute Brain Injury: A Multidatabase Observational Study
- Distinct Multimodal Brain Profiles Bridging Age of First Alcohol Use and Subsequent Substance Use in Young Adults
- Invasive Aspergillosis Complicating Severe COVID-19: Cumulative Incidence, Risk Factors, and Outcomes Between the First Wave of the Pandemic and Subsequent Waves, According to the ECMM/ISHAM Classification and a Local Case Assessment
- First-Trimester Lipid Profile and Subsequent Gestational Diabetes Mellitus: A Retrospective Case–Control Study
BibTeX
@article{dzubinski2026retina,
title = {{Retina status at first ROP exam and the subsequent development of type 1 ROP}},
author = {Lance C. Dzubinski and Nathan C. Grove and Emily A. Auer and Arden J. McReynolds and Anne M. Lynch and Ryan A. Frisbie and Jennifer L. Jung and Scott C.N. Oliver and Emily A. McCourt},
journal = {International Journal of Ophthalmology},
year = {2026},
month = nov,
doi = {10.18240/ijo.2026.11.21},
url = {https://doi.org/10.18240/ijo.2026.11.21},
note = {CC BY-NC-ND},
}
RIS
TY - JOUR
TI - Retina status at first ROP exam and the subsequent development of type 1 ROP
AU - Lance C. Dzubinski
AU - Nathan C. Grove
AU - Emily A. Auer
AU - Arden J. McReynolds
AU - Anne M. Lynch
AU - Ryan A. Frisbie
AU - Jennifer L. Jung
AU - Scott C.N. Oliver
AU - Emily A. McCourt
PY - 2026
DA - 2026/11/02
JO - International Journal of Ophthalmology
DO - 10.18240/ijo.2026.11.21
UR - https://doi.org/10.18240/ijo.2026.11.21
AB - AIM: To evaluate the association between findings at the first retinopathy of prematurity (ROP) exam and the subsequent development of type 1 ROP in a large registry of infants. METHODS: A retrospective cohort study of the records of infants (n=1582) screened for ROP (2013–2022) was conducted using an ROP registry. Logistic regression using generalized estimating equations was used to estimate odds ratios (OR) and 95% confidence intervals (CI) of developing type 1 ROP following any ROP at initial exam, or for infants who required a one-week follow-up exam following initial exam. RESULTS: Gestational age at delivery of 1582 infants (834 males) were 28.8±2.5wk. Infants with any ROP noted at initial exam had increased odds of developing type 1 ROP [OR=3.64, 95%CI (1.93, 6.88), P<0.001] compared to infants without any ROP noted at initial exam. Infants who required a one-week follow-up exam for any reason after initial ROP exam had even higher odds of developing type 1 ROP [OR=9.31, 95%CI (5.63, 15.4), P<0.001] compared to infants who did not require a one-week follow-up exam. CONCLUSION: Infants with ROP noted at initial exam and infants requiring a one-week follow-up exam are significantly more likely to develop type 1 ROP. When signs of ROP or concern for ROP are noted by the ophthalmologist at the first ROP exam, there is a significant increase in the likelihood of developing type 1 ROP. These data will assist ophthalmologists in informing families and neonatologists of the risk of ROP from the onset of ROP exams.
SN - 2222-3959
SN - 2227-4898
ER -