Skip to content
DraconiticResearch
Search Sources API
203,952 studies31 sourcesUpdated just now
Peer-reviewedCC BY 4.0DEN Open

Long‐term Endoscopic Evolution of a Pyloric Gland Adenoma Arising in Nonatrophic Gastric Mucosa and Initially Resembling a Fundic Gland Polyp

  • Ryohei Kobayashi1
  • Hiroyuki Nakanishi1
  • Kenta Takaura1
  • Shohei Tanaka1
  • Chiaki Maeyashiki1
  • Nobuharu Tamaki1
  • Yutaka Yasui1
  • Urara Sakurai2
  • Kaoru Tsuchiya1
  • Masayuki Kurosaki1
  1. 1Department of Gastroenterology and Hepatology Musashino Red Cross Hospital Tokyo Japan
  2. 2Department of Diagnostic Pathology Musashino Red Cross Hospital Tokyo Japan
Read full textPDFDOICite

Abstract

Pyloric gland adenoma (PGA) is a rare gastric epithelial neoplasm often associated with autoimmune or metaplastic atrophic gastritis. An 80‐year‐old man underwent serial upper gastrointestinal endoscopy. A small gastric fundus lesion initially resembling a fundic gland polyp (FGP) was followed without biopsy. Over 11 years, it enlarged to 22 mm and became increasingly whitish, against a background described endoscopically as nonatrophic. Biopsy suggested PGA, and the lesion was resected en bloc by endoscopic submucosal dissection. Closely packed pyloric‐type glands showed elongation, tortuosity, branching, and cystic dilatation, with diffuse MUC6 expression and MUC5AC expression restricted to the surface epithelium. The lesion was diagnosed as PGA with low‐grade dysplasia. The adjacent oxyntic mucosa showed no atrophy, lymphoplasmacytic infiltration, or nodular enterochromaffin‐like cell hyperplasia. Without an initial biopsy, whether the lesion was already PGA or developed within a pre‐existing FGP remains unknown. An enlarging or increasingly whitish FGP‐like lesion warrants histologic assessment, even in nonatrophic gastric mucosa.

Related

  1. Technical evolution of totally endoscopic coronary artery bypass on the da Vinci Xi platform: Lessons learned from the first 84 cases
    Gianluca Torregrossa, Massimo Baudo, Amanda Yakobitis +3
    JTCVS techniquesPeer-reviewedCC BY-NC-NDFull textGeneral medicineEurope PMC
  2. Refractory Gastroparesis in Ehlers-Danlos Syndrome: Failure of Pyloric-Directed Therapy Despite Normal Pyloric Physiology.
    Katherine Stevens, Michael Herman
    CureusPeer-reviewedCC BYFull textGeneral medicineEurope PMC
  3. Off‐Label use of a lumen‐apposing metal stent for refractory pyloric stricture in a toddler
    Hamza Hassan Khan, Prateek Wali, Sumant Inamdar
    JPGN reportsPeer-reviewedCC BYFull textSurgery & anaesthesiaEurope PMCEurope PMCPMC
  4. Pyloric Pseudonecrosis Caused by Biliary Peritonitis: A Rare Intraoperative Pitfall
    Christian Mouawad, Dollen Eid, Nehad Dager
    Clinical Case ReportsPeer-reviewedCC BYFull textGeneral medicineDOAJ
  5. A Systematic Review: Role of Pyloric Dilation in the Management of Gastroparesis.
    Milli Gupta, Alberto Barchi, Albert J Bredenoord +1
    Neurogastroenterology and motilityPeer-reviewedCC BYFull textGeneral medicineEurope PMC

Cite

BibTeXRIS
BibTeX
@article{kobayashi2026longterm,
  title = {{Long‐term Endoscopic Evolution of a Pyloric Gland Adenoma Arising in Nonatrophic Gastric Mucosa and Initially Resembling a Fundic Gland Polyp}},
  author = {Ryohei Kobayashi and Hiroyuki Nakanishi and Kenta Takaura and Shohei Tanaka and Chiaki Maeyashiki and Nobuharu Tamaki and Yutaka Yasui and Urara Sakurai and Kaoru Tsuchiya and Masayuki Kurosaki},
  journal = {DEN Open},
  year = {2026},
  month = nov,
  doi = {10.1002/deo2.70464},
  url = {https://doi.org/10.1002/deo2.70464},
  note = {CC BY 4.0},
}
RIS
TY  - JOUR
TI  - Long‐term Endoscopic Evolution of a Pyloric Gland Adenoma Arising in Nonatrophic Gastric Mucosa and Initially Resembling a Fundic Gland Polyp
AU  - Ryohei Kobayashi
AU  - Hiroyuki Nakanishi
AU  - Kenta Takaura
AU  - Shohei Tanaka
AU  - Chiaki Maeyashiki
AU  - Nobuharu Tamaki
AU  - Yutaka Yasui
AU  - Urara Sakurai
AU  - Kaoru Tsuchiya
AU  - Masayuki Kurosaki
PY  - 2026
DA  - 2026/11/04
JO  - DEN Open
DO  - 10.1002/deo2.70464
UR  - https://doi.org/10.1002/deo2.70464
AB  - Pyloric gland adenoma (PGA) is a rare gastric epithelial neoplasm often associated with autoimmune or metaplastic atrophic gastritis. An 80‐year‐old man underwent serial upper gastrointestinal endoscopy. A small gastric fundus lesion initially resembling a fundic gland polyp (FGP) was followed without biopsy. Over 11 years, it enlarged to 22 mm and became increasingly whitish, against a background described endoscopically as nonatrophic. Biopsy suggested PGA, and the lesion was resected en bloc by endoscopic submucosal dissection. Closely packed pyloric‐type glands showed elongation, tortuosity, branching, and cystic dilatation, with diffuse MUC6 expression and MUC5AC expression restricted to the surface epithelium. The lesion was diagnosed as PGA with low‐grade dysplasia. The adjacent oxyntic mucosa showed no atrophy, lymphoplasmacytic infiltration, or nodular enterochromaffin‐like cell hyperplasia. Without an initial biopsy, whether the lesion was already PGA or developed within a pre‐existing FGP remains unknown. An enlarging or increasingly whitish FGP‐like lesion warrants histologic assessment, even in nonatrophic gastric mucosa.
SN  - 2692-4609
ER  -