Recurrent Mesonephric-like Adenocarcinoma of the Ovary with Bladder and Vaginal Recurrences: A Diagnostic Challenge.
7 affiliations
- 1Faculty of Medicine, Carol Davila University of Medicine and Pharmacy, 050474 Bucharest, Romania.
- 2Department of Pathology, Saint Mary Clinical Hospital, 011192 Bucharest, Romania.
- 3Department of Pathology and Molecular Biology, Pathoteam Diagnostic, 051923 Bucharest, Romania.
- 4Department of Surgery I, Clinical County Hospital, 200642 Craiova, Romania.
- 5Faculty of Medicine, University of Medicine and Pharmacy, 200349 Craiova, Romania.
- 6Department of Radiology, SPAD Imaging, 200352 Craiova, Romania.
- 7Medical Oncology Department, OncoClinic Consult, 200094 Craiova, Romania.
Abstract
Background and Clinical Significance: Mesonephric-like adenocarcinoma (MLA) of the ovary is a very rare entity that has only recently been recognized as a distinct subtype in the World Health Organization (WHO) classification. It is an aggressive tumor with a propensity for recurrence. The aim of this case report was to highlight the diagnostic challenges associated with MLA and the importance of immunohistochemical and molecular testing. Case Presentation: We report the case of a 59-year-old woman who presented with a left ovarian tumor. Histopathological examination led to an initial diagnosis of low-grade serous carcinoma, and the patient was treated accordingly. Five years later, the tumor recurred in the bladder wall and was initially interpreted as urothelial carcinoma. One year later, a further recurrence was identified at the vaginal cuff. Integrated review of the original ovarian tumor and recurrent lesions, together with immunohistochemical and molecular findings, supported the diagnosis of ovarian MLA with bladder and vaginal recurrences. Conclusions: Ovarian MLA is extremely rare and can mimic more common ovarian carcinoma subtypes. Awareness of its morphological and immunohistochemical features is essential to avoid misdiagnosis. MLA should be considered in recurrent gynecologic tumors with mesonephric morphology/immunophenotype even when the recurrence occurs in an unusual site such as the bladder and mimics a primary urinary malignancy.
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BibTeX
@article{evseiseceleanu2026recurrent,
title = {{Recurrent Mesonephric-like Adenocarcinoma of the Ovary with Bladder and Vaginal Recurrences: A Diagnostic Challenge.}},
author = {Anca Evsei-Seceleanu and Tudor Turcu and Aurelian Mihai Ghita and Sandu-Dumitru Ramboiu and Alexandru Ciobanu and Patricia Visan},
journal = {Diagnostics (Basel, Switzerland)},
year = {2026},
month = sep,
doi = {10.3390/diagnostics16193099},
url = {https://europepmc.org/article/MED/42882254},
note = {CC BY},
}
RIS
TY - JOUR
TI - Recurrent Mesonephric-like Adenocarcinoma of the Ovary with Bladder and Vaginal Recurrences: A Diagnostic Challenge.
AU - Anca Evsei-Seceleanu
AU - Tudor Turcu
AU - Aurelian Mihai Ghita
AU - Sandu-Dumitru Ramboiu
AU - Alexandru Ciobanu
AU - Patricia Visan
PY - 2026
DA - 2026/09/24
JO - Diagnostics (Basel, Switzerland)
DO - 10.3390/diagnostics16193099
UR - https://europepmc.org/article/MED/42882254
AB - Background and Clinical Significance: Mesonephric-like adenocarcinoma (MLA) of the ovary is a very rare entity that has only recently been recognized as a distinct subtype in the World Health Organization (WHO) classification. It is an aggressive tumor with a propensity for recurrence. The aim of this case report was to highlight the diagnostic challenges associated with MLA and the importance of immunohistochemical and molecular testing. Case Presentation: We report the case of a 59-year-old woman who presented with a left ovarian tumor. Histopathological examination led to an initial diagnosis of low-grade serous carcinoma, and the patient was treated accordingly. Five years later, the tumor recurred in the bladder wall and was initially interpreted as urothelial carcinoma. One year later, a further recurrence was identified at the vaginal cuff. Integrated review of the original ovarian tumor and recurrent lesions, together with immunohistochemical and molecular findings, supported the diagnosis of ovarian MLA with bladder and vaginal recurrences. Conclusions: Ovarian MLA is extremely rare and can mimic more common ovarian carcinoma subtypes. Awareness of its morphological and immunohistochemical features is essential to avoid misdiagnosis. MLA should be considered in recurrent gynecologic tumors with mesonephric morphology/immunophenotype even when the recurrence occurs in an unusual site such as the bladder and mimics a primary urinary malignancy.
SN - 2075-4418
ER -