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PreprintCC BYbioRxiv

Distinct genetic requirements underlie LITE-1-dependent photosensation and avoidance of high concentration of diacetyl in C. elegans

  • A. Koh
  • C. Chen
  • A. E. Brown1
  1. 1Imperial College London
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Abstract

The eyeless nematode C. elegans can detect and respond to aversive blue and ultraviolet light using the gustatory receptor homolog LITE-1. In addition to its role in phototransduction, LITE-1 also functions as a chemoreceptor for the odorants diacetyl and 2,3-pentanedione. However, whether these different sensory modalities rely on the same downstream signalling components is unknown. In this study, we provide behavioural evidence that unlike its LITE-1-dependent photosensory function which relies on cGMP signalling components, its chemosensory function remains intact in mutants with disrupted cGMP signalling.

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Cite

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BibTeX
@misc{koh2026distinct,
  title = {{Distinct genetic requirements underlie LITE-1-dependent photosensation and avoidance of high concentration of diacetyl in C. elegans}},
  author = {A. Koh and C. Chen and A. E. Brown},
  howpublished = {bioRxiv},
  year = {2026},
  month = oct,
  doi = {10.64898/2026.10.13.758841},
  url = {https://www.biorxiv.org/content/10.64898/2026.10.13.758841v1},
  note = {CC BY},
}
RIS
TY  - UNPB
TI  - Distinct genetic requirements underlie LITE-1-dependent photosensation and avoidance of high concentration of diacetyl in C. elegans
AU  - A. Koh
AU  - C. Chen
AU  - A. E. Brown
PY  - 2026
DA  - 2026/10/13
PB  - bioRxiv
DO  - 10.64898/2026.10.13.758841
UR  - https://www.biorxiv.org/content/10.64898/2026.10.13.758841v1
AB  - The eyeless nematode C. elegans can detect and respond to aversive blue and ultraviolet light using the gustatory receptor homolog LITE-1. In addition to its role in phototransduction, LITE-1 also functions as a chemoreceptor for the odorants diacetyl and 2,3-pentanedione. However, whether these different sensory modalities rely on the same downstream signalling components is unknown. In this study, we provide behavioural evidence that unlike its LITE-1-dependent photosensory function which relies on cGMP signalling components, its chemosensory function remains intact in mutants with disrupted cGMP signalling.
ER  -