Lymphangiogenesis-Related Prognostic Genes in Oral Squamous Cell Carcinoma
- 1Department of Oral and Maxillofacial Surgery, College & Hospital of Stomatology, Guangxi Medical University, Nanning, PR China
- 2Department of Oral and Maxillofacial Surgery, College & Hospital of Stomatology, Guangxi Medical University, Nanning, PR China; Guangxi Key Laboratory of the Rehabilitation and Reconstruction of Oral and Maxillofacial Research, Nanning, PR China; Guangxi Clinical Research Center for Craniofacial Deformity, Nanning, PR China
Abstract
Introduction and aims: Lymphangiogenesis (LYM) significantly influences oral squamous cell carcinoma (OSCC) development, necessitating identification of associated prognostic genes to improve clinical management. Methods: Differentially expressed genes and LYM-related genes were analysed. Prognostic genes were selected via regression, and a risk model was constructed. Functional, immune, and drug analyses were performed, followed by single-cell RNA-sequencing validation. Results: IL17F, CCL26, OLR1, Kelch-like family member 6, and IL17A were identified as prognostic genes. The developed risk model showed that high-risk group patients had a poorer survival rate. Next, there were differences between high-risk group and low-risk group in the infiltration levels of 13 immune cells. Then, in the drug prediction analysis, decitabine and titanium dioxide were found to target IL17A and OLR1 simultaneously. Finally, through the single-cell RNA-sequencing-level analysis, macrophages were identified as the key cells and contained 7 differentiation states. Notably, the overall expression level of OLR1 was relatively high during the differentiation stage of macrophages, and it first decreased and then increased. Conclusions: IL17F, CCL26, OLR1, Kelch-like family member 6, and IL17A were identified as prognostic genes, offering fresh perspectives on OSCC patient diagnosis and prognosis. Clinical relevance: The 5-gene signature provides a novel tool for prognostic stratification of OSCC patients, which could aid in personalized risk assessment. Additionally, the identified genes and their associated immune profiles offer potential targets for future therapeutic development.
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BibTeX
@article{wei2026lymphangiogenesisrelated,
title = {{Lymphangiogenesis-Related Prognostic Genes in Oral Squamous Cell Carcinoma}},
author = {Jinzhi Wei and Yinyu Shang and Jin Qian and Huiqing Lan and Xuanping Huang},
journal = {International Dental Journal},
year = {2026},
month = oct,
doi = {10.1016/j.identj.2026.111266},
url = {https://doi.org/10.1016/j.identj.2026.111266},
note = {CC BY},
}
RIS
TY - JOUR
TI - Lymphangiogenesis-Related Prognostic Genes in Oral Squamous Cell Carcinoma
AU - Jinzhi Wei
AU - Yinyu Shang
AU - Jin Qian
AU - Huiqing Lan
AU - Xuanping Huang
PY - 2026
DA - 2026/10/30
JO - International Dental Journal
DO - 10.1016/j.identj.2026.111266
UR - https://doi.org/10.1016/j.identj.2026.111266
AB - Introduction and aims: Lymphangiogenesis (LYM) significantly influences oral squamous cell carcinoma (OSCC) development, necessitating identification of associated prognostic genes to improve clinical management. Methods: Differentially expressed genes and LYM-related genes were analysed. Prognostic genes were selected via regression, and a risk model was constructed. Functional, immune, and drug analyses were performed, followed by single-cell RNA-sequencing validation. Results: IL17F, CCL26, OLR1, Kelch-like family member 6, and IL17A were identified as prognostic genes. The developed risk model showed that high-risk group patients had a poorer survival rate. Next, there were differences between high-risk group and low-risk group in the infiltration levels of 13 immune cells. Then, in the drug prediction analysis, decitabine and titanium dioxide were found to target IL17A and OLR1 simultaneously. Finally, through the single-cell RNA-sequencing-level analysis, macrophages were identified as the key cells and contained 7 differentiation states. Notably, the overall expression level of OLR1 was relatively high during the differentiation stage of macrophages, and it first decreased and then increased. Conclusions: IL17F, CCL26, OLR1, Kelch-like family member 6, and IL17A were identified as prognostic genes, offering fresh perspectives on OSCC patient diagnosis and prognosis. Clinical relevance: The 5-gene signature provides a novel tool for prognostic stratification of OSCC patients, which could aid in personalized risk assessment. Additionally, the identified genes and their associated immune profiles offer potential targets for future therapeutic development.
SN - 0020-6539
SN - 1875-595X
ER -