Peer-reviewedCC BY-NC-NDInternal Medicine
Cronkhite-Canada Syndrome Associated with Primary Cutaneous Peripheral T-cell Lymphoma and Membranous Nephropathy: A Case Report
Abstract
Cronkhite-Canada syndrome (CCS) is a rare disorder characterized by gastrointestinal polyposis and ectodermal abnormalities. We report the case of a 64-year-old man with CCS complicated by primary cutaneous peripheral T-cell lymphoma (PC-PTCL) and membranous nephropathy. Cutaneous lymphoma was controlled using topical corticosteroids and phototherapy. During the clinical course of CCS, the patient developed proteinuria, and a renal biopsy revealed membranous nephropathy with equivocal phospholipase A2 receptor staining. Corticosteroid therapy improved both the gastrointestinal manifestations and proteinuria. This case suggests a possible immune-mediated association among CCS, PC-PTCL, and membranous nephropathy.
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BibTeX
@article{kiso2026cronkhitecanada,
title = {{Cronkhite-Canada Syndrome Associated with Primary Cutaneous Peripheral T-cell Lymphoma and Membranous Nephropathy: A Case Report}},
author = {Kohei Kiso and Yusuke Shimoyama and Saki Okuda-Hiwatashi and Taku Fujimura and Yoshihide Asano and Rui Makino and Tetsuhiro Tanaka and Hideya Iwaki and Daisuke Okamoto and Hiroshi Nagai and Takeo Naito and Rintaro Moroi and Yoichi Kakuta and Atsushi Masamune},
journal = {Internal Medicine},
year = {2026},
month = sep,
doi = {10.2169/internalmedicine.7143-26},
url = {https://www.jstage.jst.go.jp/article/internalmedicine/advpub/0/advpub_7143-26/_article},
note = {CC BY-NC-ND},
}
RIS
TY - JOUR
TI - Cronkhite-Canada Syndrome Associated with Primary Cutaneous Peripheral T-cell Lymphoma and Membranous Nephropathy: A Case Report
AU - Kohei Kiso
AU - Yusuke Shimoyama
AU - Saki Okuda-Hiwatashi
AU - Taku Fujimura
AU - Yoshihide Asano
AU - Rui Makino
AU - Tetsuhiro Tanaka
AU - Hideya Iwaki
AU - Daisuke Okamoto
AU - Hiroshi Nagai
AU - Takeo Naito
AU - Rintaro Moroi
AU - Yoichi Kakuta
AU - Atsushi Masamune
PY - 2026
DA - 2026/09/22
JO - Internal Medicine
DO - 10.2169/internalmedicine.7143-26
UR - https://www.jstage.jst.go.jp/article/internalmedicine/advpub/0/advpub_7143-26/_article
AB - Cronkhite-Canada syndrome (CCS) is a rare disorder characterized by gastrointestinal polyposis and ectodermal abnormalities. We report the case of a 64-year-old man with CCS complicated by primary cutaneous peripheral T-cell lymphoma (PC-PTCL) and membranous nephropathy. Cutaneous lymphoma was controlled using topical corticosteroids and phototherapy. During the clinical course of CCS, the patient developed proteinuria, and a renal biopsy revealed membranous nephropathy with equivocal phospholipase A2 receptor staining. Corticosteroid therapy improved both the gastrointestinal manifestations and proteinuria. This case suggests a possible immune-mediated association among CCS, PC-PTCL, and membranous nephropathy.
SN - 1349-7235
SN - 0918-2918
ER -