Front-end and Back-end Computational Modeling of 40-Hz Auditory Steady-State Response Abnormalities in Schizophrenia
Abstract
40-Hz ASSR is reduced in schizophrenia, but it is unclear if this reflects altered auditory input or cortical E/I dynamics. We hypothesized that similar group differences could arise via distinct model mechanisms. EEG gamma% and ITPC from 21 HC and 21 SCZ constrained an auditory front-end coupled to a Wilson-Cowan E/I model. We compared front-end-restricted, back-end-restricted, and full-joint parameter searches, plus perturbation and fixed-point analyses. HC means exceeded SCZ for both metrics (not individually significant). All three models reproduced HC>SCZ but located group differences differently: front-end via input transformation, back-end via cortical dynamics, full-joint via both. The full-joint solution was most robust to perturbation. Fixed-point analysis revealed similar outputs with distinct local dynamics. All models reproduced the HC>SCZ pattern, suggesting schizophrenia pathophysiology may involve altered sensory encoding, altered cortical E/I, or both. This framework enables future patient-level mechanistic comparison and, after validation, may support individualized stratification.
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BibTeX
@misc{xia2026frontend,
title = {{Front-end and Back-end Computational Modeling of 40-Hz Auditory Steady-State Response Abnormalities in Schizophrenia}},
author = {Wenjun Xia and Yan Xu and Zhengdi Zhang},
howpublished = {arXiv},
year = {2026},
month = aug,
doi = {10.48550/arxiv.2608.29104},
eprint = {2608.29104},
archivePrefix = {arXiv},
url = {https://arxiv.org/abs/2608.29104},
note = {CC BY-NC-SA 4.0},
}
RIS
TY - UNPB
TI - Front-end and Back-end Computational Modeling of 40-Hz Auditory Steady-State Response Abnormalities in Schizophrenia
AU - Wenjun Xia
AU - Yan Xu
AU - Zhengdi Zhang
PY - 2026
DA - 2026/08/29
PB - arXiv
DO - 10.48550/arxiv.2608.29104
UR - https://arxiv.org/abs/2608.29104
AB - 40-Hz ASSR is reduced in schizophrenia, but it is unclear if this reflects altered auditory input or cortical E/I dynamics. We hypothesized that similar group differences could arise via distinct model mechanisms. EEG gamma% and ITPC from 21 HC and 21 SCZ constrained an auditory front-end coupled to a Wilson-Cowan E/I model. We compared front-end-restricted, back-end-restricted, and full-joint parameter searches, plus perturbation and fixed-point analyses. HC means exceeded SCZ for both metrics (not individually significant). All three models reproduced HC>SCZ but located group differences differently: front-end via input transformation, back-end via cortical dynamics, full-joint via both. The full-joint solution was most robust to perturbation. Fixed-point analysis revealed similar outputs with distinct local dynamics. All models reproduced the HC>SCZ pattern, suggesting schizophrenia pathophysiology may involve altered sensory encoding, altered cortical E/I, or both. This framework enables future patient-level mechanistic comparison and, after validation, may support individualized stratification.
ER -