Sensitivity and Identifiability of Tumor-Related Changes in Longitudinal Microwave Breast Imaging
Abstract
Microwave imaging could monitor breast tumor response to neoadjuvant chemotherapy, but between-visit changes in breast positioning and normal tissue may confound tumor-related changes. We use eight patient-specific dielectric models from longitudinal MRI of two patients at four time points. For each model, 24-port S-parameters were simulated from 1 to 3 GHz, and Jacobians computed for tumor permittivity and loss, fibroglandular tissue (FGT) permittivity, and breast rotation and translation. 1 mm positioning changes produced changes 20 to 50 times larger than a 10% tumor permittivity change above 2 GHz. Nevertheless, tumor sensitivity patterns were weakly aligned with positioning patterns, tumor-FGT similarity exceeded 0.8 at only some visits, and the Jacobians remained well conditioned. Tumor responses are thus small but separable; monitoring will require positioning correction, frequency selection, and noise-aware detectability analysis.
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BibTeX
@misc{shafiei2026sensitivity,
title = {{Sensitivity and Identifiability of Tumor-Related Changes in Longitudinal Microwave Breast Imaging}},
author = {Somayeh B. Shafiei and Ian Jeffrey and Vahab Khoshdel and Joe LoVetri},
howpublished = {arXiv},
year = {2026},
month = oct,
doi = {10.48550/arxiv.2610.26630},
eprint = {2610.26630},
archivePrefix = {arXiv},
url = {https://arxiv.org/abs/2610.26630},
}
RIS
TY - UNPB
TI - Sensitivity and Identifiability of Tumor-Related Changes in Longitudinal Microwave Breast Imaging
AU - Somayeh B. Shafiei
AU - Ian Jeffrey
AU - Vahab Khoshdel
AU - Joe LoVetri
PY - 2026
DA - 2026/10/19
PB - arXiv
DO - 10.48550/arxiv.2610.26630
UR - https://arxiv.org/abs/2610.26630
AB - Microwave imaging could monitor breast tumor response to neoadjuvant chemotherapy, but between-visit changes in breast positioning and normal tissue may confound tumor-related changes. We use eight patient-specific dielectric models from longitudinal MRI of two patients at four time points. For each model, 24-port S-parameters were simulated from 1 to 3 GHz, and Jacobians computed for tumor permittivity and loss, fibroglandular tissue (FGT) permittivity, and breast rotation and translation. 1 mm positioning changes produced changes 20 to 50 times larger than a 10% tumor permittivity change above 2 GHz. Nevertheless, tumor sensitivity patterns were weakly aligned with positioning patterns, tumor-FGT similarity exceeded 0.8 at only some visits, and the Jacobians remained well conditioned. Tumor responses are thus small but separable; monitoring will require positioning correction, frequency selection, and noise-aware detectability analysis.
ER -