Peer-reviewedCC BY-NC 4.0Neurointervention
Association of Estimated Arterial Stiffness with Collateral Status and Functional Outcome after Endovascular Thrombectomy: A Secondary Analysis of the OPTIMAL-BP Trial
29 affiliations
- 1Department of Neurology, Yonsei University College of Medicine, Seoul, Korea
- 2Integrative Research Center for Cerebrovascular and Cardiovascular Diseases, Yonsei University College of Medicine, Seoul, Korea
- 3Department of Neurology, Kyungpook National University Chilgok Hospital, School of Medicine, Kyungpook National University, Daegu, Korea
- 4Department of Neurology, Keimyung University Dongsan Hospital, Keimyung University School of Medicine, Daegu, Korea
- 5Department of Neurology, Seoul Medical Center, Seoul, Korea
- 6Department of Neurology, Kyung Hee University Hospital at Gangdong, Seoul, Korea
- 7Department of Radiology, Yonsei University College of Medicine, Seoul, Korea
- 8Department of Neurology, Korea University Anam Hospital, Korea University College of Medicine, Seoul, Korea
- 9Department of Neurology, Chosun University School of Medicine, Gwangju, Korea
- 10Department of Neurology, Ewha Womans University Seoul Hospital, Ewha Womans University College of Medicine, Seoul, Korea
- 11Graduate Program in System Health Science and Engineering, Ewha Womans University, Seoul, Korea
- 12Department of Neurology, Ewha Womans University Mokdong Hospital, Ewha Womans University College of Medicine, Seoul, Korea
- 13Department of Neurology, National Health Insurance Service Ilsan Hospital, Goyang, Korea
- 14Department of Neurology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea
- 15Department of Neurology, Dong-A University Hospital, Busan, Korea
- 16Department of Neurology, Busan Paik Hospital, Inje University College of Medicine, Busan, Korea
- 17Department of Neurology, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea
- 18Department of Neurology, Pusan National University School of Medicine, Busan, Korea
- 19Department of Neurology, Gachon University Gil Medical Center, Incheon, Korea
- 20Department of Neurology, Yongin Severance Hospital, Yonsei University College of Medicine, Yongin, Korea
- 21Department of Neurology, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Korea
- 22Department of Neurology, Kyungpook National University Hospital, School of Medicine, Kyungpook National University, Daegu, Korea
- 23Department of Neurology, Korea University Guro Hospital, Korea University College of Medicine, Seoul, Korea
- 24Department of Neurology, Daejeon Eulji Medical Center, Eulji University School of Medicine, Daejeon, Korea
- 25Department of Health Promotion, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea
- 26Cardiovascular Research Institute, Yonsei University College of Medicine, Seoul, Korea
- 27Department of Research Affairs, Biostatistics Collaboration Unit, Yonsei University College of Medicine, Seoul, Korea
- 28Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
- 29Department of Neurology, CHA Bundang Medical Center, CHA University School of Medicine, Seongnam, Korea
Abstract
Purpose: Estimated pulse wave velocity (ePWV) is a surrogate of arterial stiffness that may influence stroke outcomes and potentially affect collateral circulation. We examined the association of ePWV with collateral status and 3-month functional outcome after successful endovascular thrombectomy and explored the contribution of collateral status to this relationship across blood pressure (BP) management strategies.
Materials and Methods: In this secondary analysis of the Outcome in Patients Treated With Intra-Arterial Thrombectomy–Optimal Blood Pressure Control trial, 285 patients were analyzed. Collateral status was assessed using the Tan scale (poor, 0–1; good, 2–3). Poor functional outcome was defined as 3-month modified Rankin Scale score of 3–6. Multivariable logistic and mediation analyses were performed to evaluate the association between ePWV and functional outcomes and to explore direct and indirect pathways.
Results: A total of 285 patients were included (mean age, 73.3±11.3 years; 40.4% women). Each 1 m/s increase in ePWV was associated with poor collaterals (adjusted odds ratio [OR] 1.276, 95% confidence interval [CI] 1.083–1.503) and poor functional outcome (adjusted OR 1.338, 95% CI 1.121–1.597). In mediation analyses, collateral status accounted for only a small proportion of the association between ePWV and poor functional outcome (indirect effect: adjusted β 0.022, 95% CI 0.001–0.053), whereas the direct effect remained significant (adjusted β 0.237, 95% CI 0.115–0.359). Neither the direct effect of ePWV on functional outcome nor the indirect effect through collateral status differed according to BP management strategy.
Conclusion: Higher ePWV was associated with poor collateral status and unfavorable functional outcome after successful reperfusion. Collateral status accounted for only a small proportion of the observed association between ePWV and functional outcome.
Related
- Association Between Hypoperfusion Intensity Ratio and Outcomes After Endovascular Thrombectomy in Posterior Circulation Stroke: A Retrospective Study
- Impact of prehospital scene-to-door time on functional outcomes after endovascular thrombectomy: insights from a regional stroke network
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- Functional outcomes and quality of life after endovascular thrombectomy in large and extensive infarcts (ASPECTS 0-5): a multicentre registry study.
- Five-Day Glycemic Patterns and 3-Month Functional Outcomes After Endovascular Thrombectomy.
BibTeX
@article{han2026association,
title = {{Association of Estimated Arterial Stiffness with Collateral Status and Functional Outcome after Endovascular Thrombectomy: A Secondary Analysis of the OPTIMAL-BP Trial}},
author = {Minho Han and Eunjeong Park and Jae Wook Jung and Hyungwoo Lee and JoonNyung Heo and Young Dae Kim and Haram Joo and Kwang Hyun Kim and Jaeseob Yun and Jin Kyo Choi and Il Hyung Lee and Byung Moon Kim and Dong Joon Kim and Na Young Shin and Bang-Hoon Cho and Seong Hwan Ahn and Hyungjong Park and Sung-Il Sohn and Jeong-Ho Hong and Tae-Jin Song and Yoonkyung Chang and Gyu Sik Kim and Kwon-Duk Seo and Kijeong Lee and Jun Young Chang and Jung Hwa Seo and Sukyoon Lee and Jang-Hyun Baek and Han-Jin Cho and Dong Hoon Shin and Jinkwon Kim and Joonsang Yoo and Minyoul Baik and Yo Han Jung and Yang-Ha Hwang and Chi Kyung Kim and Jae Guk Kim and Chan Joo Lee and Sungha Park and Soyoung Jeon and Hye Sun Lee and Sun U Kwon and Oh Young Bang and Ji Hoe Heo and Hyo Suk Nam and for the OPTIMAL-BP trial investigators},
journal = {Neurointervention},
year = {2026},
month = oct,
doi = {10.5469/neuroint.2026.00822},
url = {https://doi.org/10.5469/neuroint.2026.00822},
note = {CC BY-NC 4.0},
}
RIS
TY - JOUR
TI - Association of Estimated Arterial Stiffness with Collateral Status and Functional Outcome after Endovascular Thrombectomy: A Secondary Analysis of the OPTIMAL-BP Trial
AU - Minho Han
AU - Eunjeong Park
AU - Jae Wook Jung
AU - Hyungwoo Lee
AU - JoonNyung Heo
AU - Young Dae Kim
AU - Haram Joo
AU - Kwang Hyun Kim
AU - Jaeseob Yun
AU - Jin Kyo Choi
AU - Il Hyung Lee
AU - Byung Moon Kim
AU - Dong Joon Kim
AU - Na Young Shin
AU - Bang-Hoon Cho
AU - Seong Hwan Ahn
AU - Hyungjong Park
AU - Sung-Il Sohn
AU - Jeong-Ho Hong
AU - Tae-Jin Song
AU - Yoonkyung Chang
AU - Gyu Sik Kim
AU - Kwon-Duk Seo
AU - Kijeong Lee
AU - Jun Young Chang
AU - Jung Hwa Seo
AU - Sukyoon Lee
AU - Jang-Hyun Baek
AU - Han-Jin Cho
AU - Dong Hoon Shin
AU - Jinkwon Kim
AU - Joonsang Yoo
AU - Minyoul Baik
AU - Yo Han Jung
AU - Yang-Ha Hwang
AU - Chi Kyung Kim
AU - Jae Guk Kim
AU - Chan Joo Lee
AU - Sungha Park
AU - Soyoung Jeon
AU - Hye Sun Lee
AU - Sun U Kwon
AU - Oh Young Bang
AU - Ji Hoe Heo
AU - Hyo Suk Nam
AU - for the OPTIMAL-BP trial investigators
PY - 2026
DA - 2026/10/08
JO - Neurointervention
DO - 10.5469/neuroint.2026.00822
UR - https://doi.org/10.5469/neuroint.2026.00822
AB - Purpose: Estimated pulse wave velocity (ePWV) is a surrogate of arterial stiffness that may influence stroke outcomes and potentially affect collateral circulation. We examined the association of ePWV with collateral status and 3-month functional outcome after successful endovascular thrombectomy and explored the contribution of collateral status to this relationship across blood pressure (BP) management strategies. Materials and Methods: In this secondary analysis of the Outcome in Patients Treated With Intra-Arterial Thrombectomy–Optimal Blood Pressure Control trial, 285 patients were analyzed. Collateral status was assessed using the Tan scale (poor, 0–1; good, 2–3). Poor functional outcome was defined as 3-month modified Rankin Scale score of 3–6. Multivariable logistic and mediation analyses were performed to evaluate the association between ePWV and functional outcomes and to explore direct and indirect pathways. Results: A total of 285 patients were included (mean age, 73.3±11.3 years; 40.4% women). Each 1 m/s increase in ePWV was associated with poor collaterals (adjusted odds ratio [OR] 1.276, 95% confidence interval [CI] 1.083–1.503) and poor functional outcome (adjusted OR 1.338, 95% CI 1.121–1.597). In mediation analyses, collateral status accounted for only a small proportion of the association between ePWV and poor functional outcome (indirect effect: adjusted β 0.022, 95% CI 0.001–0.053), whereas the direct effect remained significant (adjusted β 0.237, 95% CI 0.115–0.359). Neither the direct effect of ePWV on functional outcome nor the indirect effect through collateral status differed according to BP management strategy. Conclusion: Higher ePWV was associated with poor collateral status and unfavorable functional outcome after successful reperfusion. Collateral status accounted for only a small proportion of the observed association between ePWV and functional outcome.
SN - 2093-9043
SN - 2233-6273
ER -