Cytomegalovirus-associated Disseminated Intravascular Coagulation in an Immunocompetent Patient: A Case Report and Literature Review
Abstract
A healthy 20-year-old woman presented with high fever and fatigue. Laboratory findings included normal complete blood counts and the absence of atypical lymphocytes. The patient had markedly elevated C-reactive protein, hyperferritinemia, and coagulation abnormalities consistent with disseminated intravascular coagulation, while imaging studies and extensive infectious and autoimmune workups were unremarkable. Serological testing and polymerase chain reaction confirmed a primary cytomegalovirus (CMV) infection. The administration of ganciclovir followed by corticosteroid therapy resulted in the improvement of the patient's clinical symptoms and laboratory findings. Clinicians should consider primary CMV infection in the differential diagnosis of severe coagulation abnormalities associated with a hyperinflammatory state, even in immunocompetent patients without atypical lymphocytosis.
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BibTeX
@article{hatakeyama2026cytomegalovirusassociated,
title = {{Cytomegalovirus-associated Disseminated Intravascular Coagulation in an Immunocompetent Patient: A Case Report and Literature Review}},
author = {Yuki Hatakeyama and Wataru Kitamura and Ayumi Kuzume and Hiroki Iriyoshi and Tomohiro Urata and Satoshi Oka and Takuya Machida and Toshi Imai},
journal = {Internal Medicine},
year = {2026},
month = jul,
doi = {10.2169/internalmedicine.7431-26},
url = {https://www.jstage.jst.go.jp/article/internalmedicine/advpub/0/advpub_7431-26/_article},
note = {CC BY-NC-ND},
}
RIS
TY - JOUR
TI - Cytomegalovirus-associated Disseminated Intravascular Coagulation in an Immunocompetent Patient: A Case Report and Literature Review
AU - Yuki Hatakeyama
AU - Wataru Kitamura
AU - Ayumi Kuzume
AU - Hiroki Iriyoshi
AU - Tomohiro Urata
AU - Satoshi Oka
AU - Takuya Machida
AU - Toshi Imai
PY - 2026
DA - 2026/07/25
JO - Internal Medicine
DO - 10.2169/internalmedicine.7431-26
UR - https://www.jstage.jst.go.jp/article/internalmedicine/advpub/0/advpub_7431-26/_article
AB - A healthy 20-year-old woman presented with high fever and fatigue. Laboratory findings included normal complete blood counts and the absence of atypical lymphocytes. The patient had markedly elevated C-reactive protein, hyperferritinemia, and coagulation abnormalities consistent with disseminated intravascular coagulation, while imaging studies and extensive infectious and autoimmune workups were unremarkable. Serological testing and polymerase chain reaction confirmed a primary cytomegalovirus (CMV) infection. The administration of ganciclovir followed by corticosteroid therapy resulted in the improvement of the patient's clinical symptoms and laboratory findings. Clinicians should consider primary CMV infection in the differential diagnosis of severe coagulation abnormalities associated with a hyperinflammatory state, even in immunocompetent patients without atypical lymphocytosis.
SN - 1349-7235
SN - 0918-2918
ER -