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Peer-reviewedLicence not statedScience translational medicine

Early-life microbiota direct an epithelial S100 program required for neonatal immunity

  • Shikha Negi1,2
  • Seika Hashimoto-Hill1,2
  • Amanda Waddell1,2
  • Laura Engleman1,2
  • Maggie Lutz1,2
  • Taylor Rice1,2
  • Lee A. Denson3
  • Bruce A. Vallance4
  • Nurit P. Azouz2,5
  • Philippe A. Tessier6
  • Sergei I. Grivennikov7
  • Hitesh Deshmukh8
1 more authors
  • Theresa Alenghat1,2
8 affiliations
  1. 1Division of Immunobiology, Cincinnati Children’s Hospital Medical Center, and Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH 45229 USA.
  2. 2Center for Inflammation and Tolerance, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH 45229 USA.
  3. 3Division of Gastroenterology, Hepatology, and Nutrition, Cincinnati Children’s Hospital Medical Center, and Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH 45229 USA.
  4. 4Department of Pediatrics, BC Children’s Hospital Research Institute and the University of British Columbia, Vancouver, British Columbia, V5Z 4H4 Canada.
  5. 5Division of Allergy and Immunology, Cincinnati Children’s Hospital Medical Center, and Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH 45229 USA.
  6. 6Infectious and Immune Diseases Division, CHU de Québec-Université Laval Research Center, Québec, G1V 4G2 Canada.
  7. 7Departments of Medicine and Biomedical Sciences, Cedars-Sinai Cancer, Cedars-Sinai Health Sciences University, Cedars-Sinai Medical Center, Los Angeles, CA, 90048 USA.
  8. 8Division of Neonatology, Cincinnati Children’s Hospital Medical Center, and Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH 45229 USA. *Current: Division of Neonatology, University of Rochester Medical Center, Rochester, NY USA
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Cite

BibTeXRIS
BibTeX
@article{negi2026earlylife,
  title = {{Early-life microbiota direct an epithelial S100 program required for neonatal immunity}},
  author = {Shikha Negi and Seika Hashimoto-Hill and Amanda Waddell and Laura Engleman and Maggie Lutz and Taylor Rice and Lee A. Denson and Bruce A. Vallance and Nurit P. Azouz and Philippe A. Tessier and Sergei I. Grivennikov and Hitesh Deshmukh and Theresa Alenghat},
  journal = {Science translational medicine},
  year = {2026},
  month = oct,
  doi = {10.1126/scitranslmed.adx6147},
  url = {https://doi.org/10.1126/scitranslmed.adx6147},
}
RIS
TY  - JOUR
TI  - Early-life microbiota direct an epithelial S100 program required for neonatal immunity
AU  - Shikha Negi
AU  - Seika Hashimoto-Hill
AU  - Amanda Waddell
AU  - Laura Engleman
AU  - Maggie Lutz
AU  - Taylor Rice
AU  - Lee A. Denson
AU  - Bruce A. Vallance
AU  - Nurit P. Azouz
AU  - Philippe A. Tessier
AU  - Sergei I. Grivennikov
AU  - Hitesh Deshmukh
AU  - Theresa Alenghat
PY  - 2026
DA  - 2026/10/07
JO  - Science translational medicine
DO  - 10.1126/scitranslmed.adx6147
UR  - https://doi.org/10.1126/scitranslmed.adx6147
SN  - 1946-6234
SN  - 1946-6242
ER  -