Protease-serpin-microbiome interactions in inflammatory bowel disease: toward integrated biomarkers of gut health
Abstract
Proteolytic imbalance involving host and microbial serine proteases and their inhibitors (serpins) contributes to intestinal barrier disruption and chronic inflammation in inflam matory bowel disease (IBD). However, the interplay among these components remains insufficiently characterized. Here, we survey 13,304 publications over five decades, to map protease-serpin-microbiome literature in IBD. Our analysis reveals a fragmented literature structure, with uneven coverage and limited cross-domain integration among host proteases, microbial proteases, and inhibitory pathways. We synthesize evidence linking these components to intestinal barrier integrity, mucosal immunity, extracellular-matrix remodeling, and microbial ecology. Considering the proteaseserpin-microbiome axis may provide an integrative direction for future studies of IBD pathogenesis, including the investigation of mechanisms underlying disease heteroge neity, prioritizing future biomarker and therapeutic studies.
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BibTeX
@article{almalki2026proteaseserpinmicrobiome,
title = {{Protease-serpin-microbiome interactions in inflammatory bowel disease: toward integrated biomarkers of gut health}},
author = {Meshal Almalki and Camilla R de Pierri and Tristan Méric and Héla Mkaouar and Donia Slimani and Vincent Mariaule and Sirine Tebassi and Nizar Akermi and Emmanuelle Maguin and Juan Hernandez and Roberto T Raittz and Moez Rhimi and Francesco Asnicar},
journal = {Gut microbes},
year = {2026},
month = sep,
doi = {10.1080/19490976.2026.2726641},
url = {https://hal.science/hal-05736225v1},
note = {CC BY 4.0},
}
RIS
TY - JOUR
TI - Protease-serpin-microbiome interactions in inflammatory bowel disease: toward integrated biomarkers of gut health
AU - Meshal Almalki
AU - Camilla R de Pierri
AU - Tristan Méric
AU - Héla Mkaouar
AU - Donia Slimani
AU - Vincent Mariaule
AU - Sirine Tebassi
AU - Nizar Akermi
AU - Emmanuelle Maguin
AU - Juan Hernandez
AU - Roberto T Raittz
AU - Moez Rhimi
AU - Francesco Asnicar
PY - 2026
DA - 2026/09/02
JO - Gut microbes
DO - 10.1080/19490976.2026.2726641
UR - https://hal.science/hal-05736225v1
AB - Proteolytic imbalance involving host and microbial serine proteases and their inhibitors (serpins) contributes to intestinal barrier disruption and chronic inflammation in inflam matory bowel disease (IBD). However, the interplay among these components remains insufficiently characterized. Here, we survey 13,304 publications over five decades, to map protease-serpin-microbiome literature in IBD. Our analysis reveals a fragmented literature structure, with uneven coverage and limited cross-domain integration among host proteases, microbial proteases, and inhibitory pathways. We synthesize evidence linking these components to intestinal barrier integrity, mucosal immunity, extracellular-matrix remodeling, and microbial ecology. Considering the proteaseserpin-microbiome axis may provide an integrative direction for future studies of IBD pathogenesis, including the investigation of mechanisms underlying disease heteroge neity, prioritizing future biomarker and therapeutic studies.
SN - 1949-0976
SN - 1949-0984
ER -