Co-occurring divergent arbitrium receptors outside canonical prophage regions in bacterial genomes
- 1Catalan Institute for Water Research (ICRA-CERCA), 17003 Girona, Spain
Abstract
Arbitrium signaling enables peptide-mediated communication among bacteriophages and regulates lysis-lysogeny decisions through diverse genetic architectures. Here, we identified two divergent AimR-like receptors in each of the alkaliphilic bacteria Alkalihalobacterium alkalinitrilicum DSM 22532 and Caldalkalibacillus mannanilyticus JCM 10596, with within-genome amino acid identities of 30.6% and 27.4%, respectively. All four receptors occurred outside predicted prophage regions, with distinct genomic neighborhoods and a putative aimP-like gene adjacent to one receptor. Despite substantial sequence divergence, structural comparisons revealed conservation within aligned regions of the AimR fold. Associations with mobile genetic elements suggest possible genomic mobility, although the evolutionary origins and functional roles of these receptors remain unresolved. These findings highlight the diversity of co-occurring AimR-like receptors in bacterial genomes.
Supplementary Information: The online version contains supplementary material available at https://doi.org/10.1007/s10142-026-02109-2.
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BibTeX
@article{balcazar2026cooccurring,
title = {{Co-occurring divergent arbitrium receptors outside canonical prophage regions in bacterial genomes}},
author = {José L. Balcázar},
journal = {Functional \& Integrative Genomics},
year = {2026},
month = nov,
doi = {10.1007/s10142-026-02109-2},
url = {https://doi.org/10.1007/s10142-026-02109-2},
note = {CC BY 4.0},
}
RIS
TY - JOUR
TI - Co-occurring divergent arbitrium receptors outside canonical prophage regions in bacterial genomes
AU - José L. Balcázar
PY - 2026
DA - 2026/11/09
JO - Functional & Integrative Genomics
DO - 10.1007/s10142-026-02109-2
UR - https://doi.org/10.1007/s10142-026-02109-2
AB - Arbitrium signaling enables peptide-mediated communication among bacteriophages and regulates lysis-lysogeny decisions through diverse genetic architectures. Here, we identified two divergent AimR-like receptors in each of the alkaliphilic bacteria Alkalihalobacterium alkalinitrilicum DSM 22532 and Caldalkalibacillus mannanilyticus JCM 10596, with within-genome amino acid identities of 30.6% and 27.4%, respectively. All four receptors occurred outside predicted prophage regions, with distinct genomic neighborhoods and a putative aimP-like gene adjacent to one receptor. Despite substantial sequence divergence, structural comparisons revealed conservation within aligned regions of the AimR fold. Associations with mobile genetic elements suggest possible genomic mobility, although the evolutionary origins and functional roles of these receptors remain unresolved. These findings highlight the diversity of co-occurring AimR-like receptors in bacterial genomes. Supplementary Information: The online version contains supplementary material available at https://doi.org/10.1007/s10142-026-02109-2.
SN - 1438-793X
SN - 1438-7948
ER -