A water-eluted polysaccharide fraction from Chinese yam alleviates DSS-induced colitis in association with gut microbiota remodeling and attenuation of ferroptosis-related alterations
- 1Department of Gastroenterology and Hepatology, The First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, Fujian Province 361003, PR China; Department of Chemical and Pharmaceutical Engineering, College of Chemical Engineering, Huaqiao University, Xiamen, Fujian Province 361021, PR China
- 2Department of Gastroenterology and Hepatology, The First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, Fujian Province 361003, PR China
- 3Department of Gastroenterology and Hepatology, The First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, Fujian Province 361003, PR China; Corresponding author at: Department of Gastroenterology and Hepatology, The First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, Fujian province 361003, PR China
Abstract
Dietary polysaccharides interact with the gut microbiota, but their relationship with ferroptosis-related alterations during colitis remains incompletely understood. This study investigated a water-eluted polysaccharide fraction from Chinese yam ( Dioscorea polystachya Turcz.; PDO) in dextran sodium sulfate (DSS)-induced colitis and examined the transferability of its associated protective phenotype using fecal microbiota transplantation (FMT). PDO-treated mice showed lower disease activity and histopathological injury, decreased colonic iron and malondialdehyde. These changes were accompanied by increased GPX4 and SLC7A11 immunofluorescence signals, decreased ferritin light chain and transferrin receptor 1 signals, and fewer mitochondrial ultrastructural abnormalities. PDO also increased fecal concentrations of acetate, propionate, and butyrate, preserved epithelial junction-protein expression, and altered gut microbial composition, including the relative abundance of Lactobacillus. Fecal transfer from PDO-treated donors reproduced several protective features in recipient mice, including lower colitis severity, changes in redox and iron-handling markers, higher fecal SCFA concentrations, and preservation of junction proteins. These findings associate PDO administration with microbiota remodeling and attenuation of ferroptosis-related biochemical and molecular alterations. They do not establish direct inhibition of ferroptotic cell death, SCFA-mediated causality, or restoration of functional intestinal permeability. PDO warrants further characterization and mechanistic evaluation as a food-derived polysaccharide fraction.
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BibTeX
@article{yuan2026watereluted,
title = {{A water-eluted polysaccharide fraction from Chinese yam alleviates DSS-induced colitis in association with gut microbiota remodeling and attenuation of ferroptosis-related alterations}},
author = {Zhong-Yu Yuan and Xin-Yu Wang and Jun Wang and Jin-Yan Zhang and Wei-Feng Huang and Li-Tao Yi},
journal = {Journal of Functional Foods},
year = {2026},
month = oct,
doi = {10.1016/j.jff.2026.107554},
url = {https://doi.org/10.1016/j.jff.2026.107554},
note = {CC BY},
}
RIS
TY - JOUR
TI - A water-eluted polysaccharide fraction from Chinese yam alleviates DSS-induced colitis in association with gut microbiota remodeling and attenuation of ferroptosis-related alterations
AU - Zhong-Yu Yuan
AU - Xin-Yu Wang
AU - Jun Wang
AU - Jin-Yan Zhang
AU - Wei-Feng Huang
AU - Li-Tao Yi
PY - 2026
DA - 2026/10/30
JO - Journal of Functional Foods
DO - 10.1016/j.jff.2026.107554
UR - https://doi.org/10.1016/j.jff.2026.107554
AB - Dietary polysaccharides interact with the gut microbiota, but their relationship with ferroptosis-related alterations during colitis remains incompletely understood. This study investigated a water-eluted polysaccharide fraction from Chinese yam ( Dioscorea polystachya Turcz.; PDO) in dextran sodium sulfate (DSS)-induced colitis and examined the transferability of its associated protective phenotype using fecal microbiota transplantation (FMT). PDO-treated mice showed lower disease activity and histopathological injury, decreased colonic iron and malondialdehyde. These changes were accompanied by increased GPX4 and SLC7A11 immunofluorescence signals, decreased ferritin light chain and transferrin receptor 1 signals, and fewer mitochondrial ultrastructural abnormalities. PDO also increased fecal concentrations of acetate, propionate, and butyrate, preserved epithelial junction-protein expression, and altered gut microbial composition, including the relative abundance of Lactobacillus. Fecal transfer from PDO-treated donors reproduced several protective features in recipient mice, including lower colitis severity, changes in redox and iron-handling markers, higher fecal SCFA concentrations, and preservation of junction proteins. These findings associate PDO administration with microbiota remodeling and attenuation of ferroptosis-related biochemical and molecular alterations. They do not establish direct inhibition of ferroptotic cell death, SCFA-mediated causality, or restoration of functional intestinal permeability. PDO warrants further characterization and mechanistic evaluation as a food-derived polysaccharide fraction.
SN - 1756-4646
SN - 2214-9414
ER -