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Peer-reviewedCC BY 4.0Cancers

Motor Deficits After Insular Glioma Surgery: Association with Postoperative Ischemia and Intraoperative Neuromonitoring

  • Gerard Plans1,2,3,4
  • Isabel Fernández-Conejero2,3,5
  • Daniel Martí1,2,3
  • Pere J. Cifre-Serra1,2,3,4
  • Albert Pons-Escoda2,3,4,6,7
  • Alejandro Fernández-Coello1,2,3,4
  • Júlia Miró2,3,5
  • Aleix Rosselló1,2,3,4
  • Andreu Gabarrós1,2,3
7 affiliations
  1. 1Department of Neurosurgery, Hospital Universitari de Bellvitge, L’Hospitalet de Llobregat, 08907 Barcelona, Spain
  2. 2Facultat de Medicina i Ciències de la Salut, Universitat de Barcelona (UB), 08036 Barcelona, Spain
  3. 3Institut d’Investigació Biomèdica de Bellvitge (IDIBELL), L’Hospitalet de Llobregat, 08908 Barcelona, Spain
  4. 4Neuro-Oncology Unit, Hospital Universitari de Bellvitge, L’Hospitalet de Llobregat, 08907 Barcelona, Spain
  5. 5Department of Neurology, Hospital Universitari de Bellvitge, L’Hospitalet de Llobregat, 08907 Barcelona, Spain
  6. 6Department of Radiology, Hospital Universitari de Bellvitge, L’Hospitalet de Llobregat, 08907 Barcelona, Spain
  7. 7Institut de Diagnòstic per la Imatge (IDI), L’Hospitalet de Llobregat, 08908 Barcelona, Spain
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Abstract

Background and Objectives: The proximity of insular gliomas to eloquent brain structures and complex vascular anatomy makes preservation of neurological function during resection challenging. This study investigates postoperative motor deficits after insular glioma resection and their association with intraoperative neuromonitoring and ischemia. Methods: In total, 64 patients who underwent insular glioma resection between 2018 and 2025 were included. Extent of resection (EOR), intraoperative MEP changes, subcortical stimulation thresholds, postoperative ischemic lesions and motor outcomes at 3 months were evaluated. Results: Median EOR was 93.4% (IQR 87.4–100%), and median residual tumor volume was 4.5 cm3 (IQR 0–8.1). MEP monitoring was performed in 56 patients (87.5%); deterioration occurred in 3 (5.4%), all of whom developed persistent deficits. MEP deterioration showed 60% sensitivity (95% CI 14.7–94.7%), 100% specificity (95% CI 93.0–100%), 100% positive predictive value (95% CI 29.2–100%), and 96.2% negative predictive value (95% CI 87.0–99.5%). The positive predictive value should be interpreted cautiously given the small number of events. Subcortical responses were elicited in 48 patients (85.7%). Tumors involving Berger–Sanai zones II and/or III had lower subcortical stimulation thresholds than tumors sparing both regions (median 4 vs. 8.5 mA; p = 0.012), although thresholds were not associated with motor deficits or ischemia. Postoperative ischemic lesions occurred in 20 patients (31.3%). Persistent motor deficits occurred in 6 patients (9.4%), all with associated ischemic lesions. Conclusions: Postoperative motor deficits were associated with ischemic lesions. MEP deterioration showed high specificity and positive predictive value, but limited sensitivity. Subcortical stimulation provided functional information about corticospinal tract proximity. These findings highlight the importance of preserving vascular supply to motor pathways during insular glioma surgery.

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Cite

BibTeXRIS
BibTeX
@article{plans2026motor,
  title = {{Motor Deficits After Insular Glioma Surgery: Association with Postoperative Ischemia and Intraoperative Neuromonitoring}},
  author = {Gerard Plans and Isabel Fernández-Conejero and Daniel Martí and Pere J. Cifre-Serra and Albert Pons-Escoda and Alejandro Fernández-Coello and Júlia Miró and Aleix Rosselló and Andreu Gabarrós},
  journal = {Cancers},
  year = {2026},
  month = nov,
  doi = {10.3390/cancers18213583},
  url = {https://www.mdpi.com/2072-6694/18/21/3583},
  note = {CC BY 4.0},
}
RIS
TY  - JOUR
TI  - Motor Deficits After Insular Glioma Surgery: Association with Postoperative Ischemia and Intraoperative Neuromonitoring
AU  - Gerard Plans
AU  - Isabel Fernández-Conejero
AU  - Daniel Martí
AU  - Pere J. Cifre-Serra
AU  - Albert Pons-Escoda
AU  - Alejandro Fernández-Coello
AU  - Júlia Miró
AU  - Aleix Rosselló
AU  - Andreu Gabarrós
PY  - 2026
DA  - 2026/11/07
JO  - Cancers
DO  - 10.3390/cancers18213583
UR  - https://www.mdpi.com/2072-6694/18/21/3583
AB  - Background and Objectives: The proximity of insular gliomas to eloquent brain structures and complex vascular anatomy makes preservation of neurological function during resection challenging. This study investigates postoperative motor deficits after insular glioma resection and their association with intraoperative neuromonitoring and ischemia. Methods: In total, 64 patients who underwent insular glioma resection between 2018 and 2025 were included. Extent of resection (EOR), intraoperative MEP changes, subcortical stimulation thresholds, postoperative ischemic lesions and motor outcomes at 3 months were evaluated. Results: Median EOR was 93.4% (IQR 87.4–100%), and median residual tumor volume was 4.5 cm3 (IQR 0–8.1). MEP monitoring was performed in 56 patients (87.5%); deterioration occurred in 3 (5.4%), all of whom developed persistent deficits. MEP deterioration showed 60% sensitivity (95% CI 14.7–94.7%), 100% specificity (95% CI 93.0–100%), 100% positive predictive value (95% CI 29.2–100%), and 96.2% negative predictive value (95% CI 87.0–99.5%). The positive predictive value should be interpreted cautiously given the small number of events. Subcortical responses were elicited in 48 patients (85.7%). Tumors involving Berger–Sanai zones II and/or III had lower subcortical stimulation thresholds than tumors sparing both regions (median 4 vs. 8.5 mA; p = 0.012), although thresholds were not associated with motor deficits or ischemia. Postoperative ischemic lesions occurred in 20 patients (31.3%). Persistent motor deficits occurred in 6 patients (9.4%), all with associated ischemic lesions. Conclusions: Postoperative motor deficits were associated with ischemic lesions. MEP deterioration showed high specificity and positive predictive value, but limited sensitivity. Subcortical stimulation provided functional information about corticospinal tract proximity. These findings highlight the importance of preserving vascular supply to motor pathways during insular glioma surgery.
SN  - 2072-6694
ER  -