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Peer-reviewedCC BYHematology, transfusion and cell therapy

Enteral nutritional therapy practices in pediatric hematopoietic stem cell transplant centers in Brazil.

  • Vitória Soares Viau1
  • Andressa Florencio da Silva2
  • Soraia Poloni3
  • Vera Lucia Bosa4
  • Estela Beatriz Behling5
5 affiliations
  1. 1Nutrition Program, School of Medicine, Federal University of Rio Grande do Sul, Porto Alegre, RS, Brazil.
  2. 2Graduate Program in Food, Nutrition and Health, Federal University of Rio Grande do Sul, Porto Alegre, RS, Brazil; Nutrition Service, Multiprofessional Residency Program in Health: Onco-Hematology, Hospital de Clínicas de Porto Alegre, Porto Alegre, RS, Brazil.
  3. 3Nutrition Service, Multiprofessional Residency Program in Health: Onco-Hematology, Hospital de Clínicas de Porto Alegre, Porto Alegre, RS, Brazil.
  4. 4Graduate Program in Food, Nutrition and Health, Federal University of Rio Grande do Sul, Porto Alegre, RS, Brazil; Nutrition Service, Multiprofessional Residency Program in Health: Women's and Children's Health, Hospital de Clínicas de Porto Alegre, Porto Alegre, RS, Brazil.
  5. 5Nutrition Service, Multiprofessional Residency Program in Health: Onco-Hematology, Hospital de Clínicas de Porto Alegre, Porto Alegre, RS, Brazil; Department of Nutrition, School of Medicine, Federal University of Rio Grande do Sul, Porto Alegre, RS, Brazil. Electronic address: [email protected].
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Abstract

Introduction

The aim of this study was to analyze the use of enteral nutritional therapy in pediatric hematopoietic stem cell transplantation centers in Brazil, addressing its application, challenges, and current practices.Methods

This cross-sectional study was conducted from May to October 2023 in Brazilian pediatric hematopoietic stem cell transplantation centers. Data were collected via a structured questionnaire sent to eligible centers, covering the use of prophylactic nasoenteral tubes, formula selection, and adaptations for gastrointestinal symptoms.Results

Seventeen transplant centers participated, predominantly located in the Southeastern region (6.91%). Among them, 82.4% routinely used prophylactic nasoenteral tubes, with polymeric formulas being the first choice in 82.4% of cases. Normocaloric formulas (0.9-1.2 kcal/mL) were also widely adopted (82.4%). For managing gastrointestinal symptoms, the most common approach was reducing the diet volume (30.6%). This study identified a gap in specialized formulas for children aged 10 to 18 years, with 47.1% of centers opting for formulas designed for adults in this age group due to a lack of alternatives.Conclusions

The study highlights regional disparities in hematopoietic stem cell transplantation services in Brazil and confirms enteral nutritional therapy as the primary nutritional support in pediatric transplantations. It also reveals the absence of consensus regarding the best formulas and management protocols, particularly for the 10- to 18-year age group. The findings point to an urgent need for further research and the development of standardized guidelines to ensure safe and effective nutritional support, improving transplant outcomes, and promoting proper growth and development in these patients.

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Cite

BibTeXRIS
BibTeX
@article{viau2026enteral,
  title = {{Enteral nutritional therapy practices in pediatric hematopoietic stem cell transplant centers in Brazil.}},
  author = {Vitória Soares Viau and Andressa Florencio da Silva and Soraia Poloni and Vera Lucia Bosa and Estela Beatriz Behling},
  journal = {Hematology, transfusion and cell therapy},
  year = {2026},
  month = oct,
  doi = {10.1016/j.htct.2026.108543},
  url = {https://europepmc.org/article/MED/42887296},
  note = {CC BY},
}
RIS
TY  - JOUR
TI  - Enteral nutritional therapy practices in pediatric hematopoietic stem cell transplant centers in Brazil.
AU  - Vitória Soares Viau
AU  - Andressa Florencio da Silva
AU  - Soraia Poloni
AU  - Vera Lucia Bosa
AU  - Estela Beatriz Behling
PY  - 2026
DA  - 2026/10/16
JO  - Hematology, transfusion and cell therapy
DO  - 10.1016/j.htct.2026.108543
UR  - https://europepmc.org/article/MED/42887296
AB  - Introduction  The aim of this study was to analyze the use of enteral nutritional therapy in pediatric hematopoietic stem cell transplantation centers in Brazil, addressing its application, challenges, and current practices.Methods  This cross-sectional study was conducted from May to October 2023 in Brazilian pediatric hematopoietic stem cell transplantation centers. Data were collected via a structured questionnaire sent to eligible centers, covering the use of prophylactic nasoenteral tubes, formula selection, and adaptations for gastrointestinal symptoms.Results  Seventeen transplant centers participated, predominantly located in the Southeastern region (6.91%). Among them, 82.4% routinely used prophylactic nasoenteral tubes, with polymeric formulas being the first choice in 82.4% of cases. Normocaloric formulas (0.9-1.2 kcal/mL) were also widely adopted (82.4%). For managing gastrointestinal symptoms, the most common approach was reducing the diet volume (30.6%). This study identified a gap in specialized formulas for children aged 10 to 18 years, with 47.1% of centers opting for formulas designed for adults in this age group due to a lack of alternatives.Conclusions  The study highlights regional disparities in hematopoietic stem cell transplantation services in Brazil and confirms enteral nutritional therapy as the primary nutritional support in pediatric transplantations. It also reveals the absence of consensus regarding the best formulas and management protocols, particularly for the 10- to 18-year age group. The findings point to an urgent need for further research and the development of standardized guidelines to ensure safe and effective nutritional support, improving transplant outcomes, and promoting proper growth and development in these patients.
SN  - 2531-1379
SN  - 2531-1387
ER  -