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Peer-reviewedCC BY-NC-ND 4.0Organic Letters

Functionalization of the 1,8-Naphthalimide Core with Weak Nucleophiles

  • Monika Mutovska
  • Konstantin Konstantinov
  • Irena Zagranyarska
  • Darío Puchán Sánchez
  • Magali Allain
  • Arthur David
  • Silvia Angelova
  • Stanimir Stoyanov
  • Clément Cabanetos
  • Yulian Zagranyarski
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Abstract

A new synthetic strategy for the functionalization of the 1,8-naphthalimide core with weak nucleophiles was developed and is presented herein. By selection of the appropriate base and reaction temperature, access to difluoro, dialkoxy (including with a fused dioxa ring), and mixed fluoro-alkoky and alkoxy-hydroxy derivatives was achieved. All of the reactions proceed rapidly on a gram scale, affording the target products in a high yield (80–97%) and purity from inexpensive, commercially available starting compounds and reagents.

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Cite

BibTeXRIS
BibTeX
@article{mutovska2026functionalization,
  title = {{Functionalization of the 1,8-Naphthalimide Core with Weak Nucleophiles}},
  author = {Monika Mutovska and Konstantin Konstantinov and Irena Zagranyarska and Darío Puchán Sánchez and Magali Allain and Arthur David and Silvia Angelova and Stanimir Stoyanov and Clément Cabanetos and Yulian Zagranyarski},
  journal = {Organic Letters},
  year = {2026},
  month = oct,
  doi = {10.1021/acs.orglett.5c05282},
  url = {https://hal.science/hal-05698602v1},
  note = {CC BY-NC-ND 4.0},
}
RIS
TY  - JOUR
TI  - Functionalization of the 1,8-Naphthalimide Core with Weak Nucleophiles
AU  - Monika Mutovska
AU  - Konstantin Konstantinov
AU  - Irena Zagranyarska
AU  - Darío Puchán Sánchez
AU  - Magali Allain
AU  - Arthur David
AU  - Silvia Angelova
AU  - Stanimir Stoyanov
AU  - Clément Cabanetos
AU  - Yulian Zagranyarski
PY  - 2026
DA  - 2026/10/08
JO  - Organic Letters
DO  - 10.1021/acs.orglett.5c05282
UR  - https://hal.science/hal-05698602v1
AB  - A new synthetic strategy for the functionalization of the 1,8-naphthalimide core with weak nucleophiles was developed and is presented herein. By selection of the appropriate base and reaction temperature, access to difluoro, dialkoxy (including with a fused dioxa ring), and mixed fluoro-alkoky and alkoxy-hydroxy derivatives was achieved. All of the reactions proceed rapidly on a gram scale, affording the target products in a high yield (80–97%) and purity from inexpensive, commercially available starting compounds and reagents.
SN  - 1523-7060
SN  - 1523-7052
ER  -