Application of dual-energy CT iodine graph parameters with serum D-dimer,fibrinogen degradation products and procalcitonin in the early diagnosis of acute pulmonary embolism
- 1Department of Radiology,Huainan First People's Hospital,The First Affiliated Hospital of Anhui University of Scienceand Technology,Huainan,Anhui 232000,China
Abstract
Objective To explore the application value of the functional parameters of iodine images from dual-energy computed tomography(DECT)combined with serum D-dimer,fibrinogen degradation products(FDP),and procalcitonin(PCT)in the early differentiation of acute pulmonary embolism(APE),providing evidence-based support for rapid clinical decision-making. Methods A total of 107 patients with clinically suspected APE at Huainan First People's Hospital from January 2023 to July 2025 were retrospectively included. Among them,35 patients were diagnosed with APE by CT pulmonary angiography(CTPA)(APE group),and 72 patients were diagnosed without APE(non-APE group). All patients completed CTPA examination and serum marker detection within 72 hours after symptom onset. The iodine concentration(IC),standardized iodine concentration(NICR),and slope K value of the energy spectrum curve in the lesion area were measured,and the levels of serum D-dimer,FDP,and PCT were detected. The differences in each index between the two groups were compared,and the correlations among the indicators were analyzed by Pearson.Before the multivariate logistic regression,multicollinearity diagnosis was conducted,and the variance inflation factor(VIF)and tolerance were calculated. Finally,the receiver operating characteristic (ROC)curves were drawn to evaluate the diagnostic efficacy of each index and the combined model. Results The IC,NICR,and K value in the APE group were significantly lower than those in the non-APE group(P<0.05),while the levels of serum D-dimer,FDP,and PCT were significantly higher than those in the non-APE group(P<0.05). Correlation analysis showed that NICR and K value were negatively correlated with D-dimer,FDP,and PCT,respectively(P<0.05). The VIF of each candidate variable ranged from 1.12 to 1.95,and the tolerance ranged from 0.51 to 0.90,indicating no obvious multicollinearity. Multivariate logistic regression showed that the increases in D-dimer and FDP were positively associated with the diagnosis of APE(P<0.05),while the increases in IC,NICR,and K value were negatively associated with the diagnosis of APE(P<0.05),and PCT did not show any statistical significance(P>0.05). ROC curve analysis showed that the area under the curve(AUC)of D-dimer,FDP,iodine concentration,NICR,and K value were 0.887,0.926,0.656,0.675,and 0.656,respectively. The combined testing model has the highest AUC at 0.941,with a sensitivity of 91.43% and a specificity of 95.83%. Conclusion The combination of DECT iodine graph parameters with serum D-dimer,FDP and PCT can significantly improve the early diagnostic efficiency of APE,and provide a more accurate and efficient clinical diagnostic tool for clinic,which is helpful to reduce missed diagnosis and misdiagnosis,optimize treatment strategies and improve the prognosis of patients.
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BibTeX
@article{mingliang2026application,
title = {{Application of dual-energy CT iodine graph parameters with serum D-dimer,fibrinogen degradation products and procalcitonin in the early diagnosis of acute pulmonary embolism}},
author = {LIU Mingliang and LIU Deshun},
journal = {Zhongguo linchuang yanjiu},
year = {2026},
month = oct,
doi = {10.13429/j.cnki.cjcr.2026.10.016},
url = {https://doi.org/10.13429/j.cnki.cjcr.2026.10.016},
note = {CC BY-NC-ND},
}
RIS
TY - JOUR
TI - Application of dual-energy CT iodine graph parameters with serum D-dimer,fibrinogen degradation products and procalcitonin in the early diagnosis of acute pulmonary embolism
AU - LIU Mingliang
AU - LIU Deshun
PY - 2026
DA - 2026/10/26
JO - Zhongguo linchuang yanjiu
DO - 10.13429/j.cnki.cjcr.2026.10.016
UR - https://doi.org/10.13429/j.cnki.cjcr.2026.10.016
AB - Objective To explore the application value of the functional parameters of iodine images from dual-energy computed tomography(DECT)combined with serum D-dimer,fibrinogen degradation products(FDP),and procalcitonin(PCT)in the early differentiation of acute pulmonary embolism(APE),providing evidence-based support for rapid clinical decision-making. Methods A total of 107 patients with clinically suspected APE at Huainan First People's Hospital from January 2023 to July 2025 were retrospectively included. Among them,35 patients were diagnosed with APE by CT pulmonary angiography(CTPA)(APE group),and 72 patients were diagnosed without APE(non-APE group). All patients completed CTPA examination and serum marker detection within 72 hours after symptom onset. The iodine concentration(IC),standardized iodine concentration(NICR),and slope K value of the energy spectrum curve in the lesion area were measured,and the levels of serum D-dimer,FDP,and PCT were detected. The differences in each index between the two groups were compared,and the correlations among the indicators were analyzed by Pearson.Before the multivariate logistic regression,multicollinearity diagnosis was conducted,and the variance inflation factor(VIF)and tolerance were calculated. Finally,the receiver operating characteristic (ROC)curves were drawn to evaluate the diagnostic efficacy of each index and the combined model. Results The IC,NICR,and K value in the APE group were significantly lower than those in the non-APE group(P<0.05),while the levels of serum D-dimer,FDP,and PCT were significantly higher than those in the non-APE group(P<0.05). Correlation analysis showed that NICR and K value were negatively correlated with D-dimer,FDP,and PCT,respectively(P<0.05). The VIF of each candidate variable ranged from 1.12 to 1.95,and the tolerance ranged from 0.51 to 0.90,indicating no obvious multicollinearity. Multivariate logistic regression showed that the increases in D-dimer and FDP were positively associated with the diagnosis of APE(P<0.05),while the increases in IC,NICR,and K value were negatively associated with the diagnosis of APE(P<0.05),and PCT did not show any statistical significance(P>0.05). ROC curve analysis showed that the area under the curve(AUC)of D-dimer,FDP,iodine concentration,NICR,and K value were 0.887,0.926,0.656,0.675,and 0.656,respectively. The combined testing model has the highest AUC at 0.941,with a sensitivity of 91.43% and a specificity of 95.83%. Conclusion The combination of DECT iodine graph parameters with serum D-dimer,FDP and PCT can significantly improve the early diagnostic efficiency of APE,and provide a more accurate and efficient clinical diagnostic tool for clinic,which is helpful to reduce missed diagnosis and misdiagnosis,optimize treatment strategies and improve the prognosis of patients.
SN - 1674-8182
ER -