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Peer-reviewedCC BY-NC 4.0American Journal of Alzheimer's Disease and Other Dementias

Social Determinants and Brain Health in PSEN1 E280A Carriers vs Non-Carriers: A Colombian Cohort

  • C. Vanessa Tumbajoy-Arango1
  • Natalia Trujillo2,3,4
  • Juan Pablo Sánchez5
  • Diego Camilo Díaz6,7
  • Stella Valencia3
  • Sandra Trujillo3
  • Diana Gómez3
7 affiliations
  1. 1Department of Psychological Studies, Universidad Icesi, Cali, Colombia
  2. 2Stempel College of Public Health and Social Work, Florida International University, Miami, FL, USA
  3. 3Mental Health Research Group, National School of Public Health, Universidad de Antioquia UdeA, Medellín, Colombia
  4. 4Atlantic Fellow for Equity in Brain Health, Global Brain Health Institute, University of California, San Francisco, CA, USA
  5. 5Group of Epidemiology, School of Public Health, Universidad de Antioquia UdeA, Medellín, Colombia
  6. 6Neuroscience Group of Antioquia (GNA), Medicine School, Universidad de Antioquia UdeA, Medellín, Colombia
  7. 7School of Social Sciences, Universidad Católica Luis Amigó, Apartadó, Colombia
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Abstract

Social determinants of health (SDOH), including education, socioeconomic status, place of residence, genetic risk, and perceived stress, influence brain health and Alzheimer’s disease (AD), yet their role in genetically at-risk populations remains underexplored. This study examined the influence of SDOH on early brain health, specifically its cognitive dimension, in Colombian individuals from the world’s largest kindred with autosomal dominant AD (ADAD) caused by the PSEN1 E280A mutation. Participants included 86 mutation carriers and 71 non-carriers. Brain health was assessed using the BHA_CS index from the TabCAT battery, and perceived stress using the PSS-14. Carriers showed significantly lower brain health and higher perceived stress than non-carriers. Multiple regression analyses identified genetic status, age, education, and place of residence as significant predictors of brain health, with higher education and urban residence associated with better performance. These results demonstrate that SDOH contribute to early cognitive variability even decades before clinical onset in ADAD.

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Cite

BibTeXRIS
BibTeX
@article{tumbajoyarango2026social,
  title = {{Social Determinants and Brain Health in PSEN1 E280A Carriers vs Non-Carriers: A Colombian Cohort}},
  author = {C. Vanessa Tumbajoy-Arango and Natalia Trujillo and Juan Pablo Sánchez and Diego Camilo Díaz and Stella Valencia and Sandra Trujillo and Diana Gómez},
  journal = {American Journal of Alzheimer's Disease and Other Dementias},
  year = {2026},
  month = sep,
  doi = {10.1177/15333175261492405},
  url = {https://doi.org/10.1177/15333175261492405},
  note = {CC BY-NC 4.0},
}
RIS
TY  - JOUR
TI  - Social Determinants and Brain Health in PSEN1 E280A Carriers vs Non-Carriers: A Colombian Cohort
AU  - C. Vanessa Tumbajoy-Arango
AU  - Natalia Trujillo
AU  - Juan Pablo Sánchez
AU  - Diego Camilo Díaz
AU  - Stella Valencia
AU  - Sandra Trujillo
AU  - Diana Gómez
PY  - 2026
DA  - 2026/09/22
JO  - American Journal of Alzheimer's Disease and Other Dementias
DO  - 10.1177/15333175261492405
UR  - https://doi.org/10.1177/15333175261492405
AB  - Social determinants of health (SDOH), including education, socioeconomic status, place of residence, genetic risk, and perceived stress, influence brain health and Alzheimer’s disease (AD), yet their role in genetically at-risk populations remains underexplored. This study examined the influence of SDOH on early brain health, specifically its cognitive dimension, in Colombian individuals from the world’s largest kindred with autosomal dominant AD (ADAD) caused by the PSEN1 E280A mutation. Participants included 86 mutation carriers and 71 non-carriers. Brain health was assessed using the BHA_CS index from the TabCAT battery, and perceived stress using the PSS-14. Carriers showed significantly lower brain health and higher perceived stress than non-carriers. Multiple regression analyses identified genetic status, age, education, and place of residence as significant predictors of brain health, with higher education and urban residence associated with better performance. These results demonstrate that SDOH contribute to early cognitive variability even decades before clinical onset in ADAD.
SN  - 1533-3175
SN  - 1938-2731
ER  -