Central Nervous System Alterations in Individuals with Long COVID: A Systematic Review.
- 1Universidade Nove de Julho (UNINOVE), Programa de Mestrado e Doutorado em Ciências da Reabilitação, São Paulo, SP, Brasil.
Abstract
Long COVID (post-COVID-19 condition) has been associated with persistent neurological and cognitive symptoms, suggesting possible central nervous system involvement beyond the acute phase of severe acute respiratory syndrome coronavirus 2 infection. A systematic review of articles published up to April 2026 was conducted following the PRISMA guidelines, and observational studies evaluating neurophysiological, structural, and functional alterations in individuals with long COVID were analyzed. Forty-two studies with substantial variability in design and methods were included; thus, the findings were synthesized narratively. The evidence indicates heterogeneous yet recurrent alterations in the central nervous system of individuals with lonf COVID, including impaired cortical excitability, abnormal cerebral oscillatory activity across multiple frequency bands, changes in functional connectivity, and structural abnormalities in neural networks. Some studies also reported imbalances in excitatory-inhibitory neurotransmission and biomarkers suggestive of neuroinflammation or axonal injury. These neurophysiological and structural alterations were commonly associated with persistent fatigue, cognitive dysfunction, and brain fog. However, the available evidence is limited by important methodological issues, including substantial heterogeneity in study populations, assessment techniques, and reported outcomes; the observational design also limited the strength of the conclusions. Taken together, the current evidence suggests a persistent and multifactorial central nervous system dysfunction in long COVID. However, definitive conclusions remain limited, and well-designed prospective longitudinal studies using standardized methods are needed to clarify the mechanisms, duration, and clinical relevance of these alterations.
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BibTeX
@article{moraes2026central,
title = {{Central Nervous System Alterations in Individuals with Long COVID: A Systematic Review.}},
author = {Janaina Ferreira de Moraes and Paulo Henrique Leite Souza and Michele Lacerda de Andrade and Raphael Mendes Ritti Dias and Fernanda Ishida Corrêa},
journal = {Revista da Sociedade Brasileira de Medicina Tropical},
year = {2026},
month = oct,
doi = {10.1590/0037-8682-0519-2026},
url = {https://europepmc.org/article/MED/42912090},
note = {CC BY},
}
RIS
TY - JOUR
TI - Central Nervous System Alterations in Individuals with Long COVID: A Systematic Review.
AU - Janaina Ferreira de Moraes
AU - Paulo Henrique Leite Souza
AU - Michele Lacerda de Andrade
AU - Raphael Mendes Ritti Dias
AU - Fernanda Ishida Corrêa
PY - 2026
DA - 2026/10/16
JO - Revista da Sociedade Brasileira de Medicina Tropical
DO - 10.1590/0037-8682-0519-2026
UR - https://europepmc.org/article/MED/42912090
AB - Long COVID (post-COVID-19 condition) has been associated with persistent neurological and cognitive symptoms, suggesting possible central nervous system involvement beyond the acute phase of severe acute respiratory syndrome coronavirus 2 infection. A systematic review of articles published up to April 2026 was conducted following the PRISMA guidelines, and observational studies evaluating neurophysiological, structural, and functional alterations in individuals with long COVID were analyzed. Forty-two studies with substantial variability in design and methods were included; thus, the findings were synthesized narratively. The evidence indicates heterogeneous yet recurrent alterations in the central nervous system of individuals with lonf COVID, including impaired cortical excitability, abnormal cerebral oscillatory activity across multiple frequency bands, changes in functional connectivity, and structural abnormalities in neural networks. Some studies also reported imbalances in excitatory-inhibitory neurotransmission and biomarkers suggestive of neuroinflammation or axonal injury. These neurophysiological and structural alterations were commonly associated with persistent fatigue, cognitive dysfunction, and brain fog. However, the available evidence is limited by important methodological issues, including substantial heterogeneity in study populations, assessment techniques, and reported outcomes; the observational design also limited the strength of the conclusions. Taken together, the current evidence suggests a persistent and multifactorial central nervous system dysfunction in long COVID. However, definitive conclusions remain limited, and well-designed prospective longitudinal studies using standardized methods are needed to clarify the mechanisms, duration, and clinical relevance of these alterations.
SN - 0037-8682
SN - 1678-9849
ER -