Skip to content
DraconiticResearch
Search Sources API
197,768 studies31 sourcesUpdated 2 min ago
Peer-reviewedCC BYScience Advances

Lotus japonicus VIH2 is an inositol pyrophosphate synthase that regulates arbuscular mycorrhiza

  • Kiran Raj1,2
  • Verena Gaugler3,4
  • Mengsi Lu5,6
  • Maren Schädel1,2
  • Philipp Gaugler3,4
  • Charlotte M. M. Grothaus3,4
  • Ulrike A. Jochimsen3,4
  • Athanasios Makris1,6
  • Simon M. Bartsch7,8,4
  • Anna M. Frentzen3,6
  • Guizhen Liu5,4
  • Michael Harings3,2
4 more authors
  • Dorothea Fiedler7,8
  • Henning Jacob Jessen5
  • Gabriel Schaaf3
  • Martina Katharina Ried1
8 affiliations
  1. 1Symbiosis Signalling Group, Department of Molecular Signal Processing, Leibniz Institute of Plant Biochemistry, 06120 Halle (Saale), Germany
  2. 2Leibniz Institute of Plant Biochemistry
  3. 3Institute of Crop Science and Resource Conservation (INRES), University of Bonn, 53115 Bonn, Germany
  4. 4University of Bonn
  5. 5Institute of Organic Chemistry and the Center for Integrative Biological Signalling Studies (CIBSS), Albert-Ludwigs-University of Freiburg, 79104 Freiburg, Germany
  6. 6University of Freiburg
  7. 7Department of Chemical Biology, Leibniz-Forschungsinstitut für Molekulare Pharmakologie, 13125 Berlin, Germany
  8. 8Institute of Chemistry, Humboldt-Universität zu Berlin, 12489 Berlin, Germany
Open at sourcePDFDOICite

Abstract

Plant yield is often maximized by the extensive use of mineral fertilizers, which, however, has severe environmental consequences. Phosphate is particularly problematic, as it represents a globally limited resource, and its runoff and soil erosion threaten open water bodies. Many crops engage in arbuscular mycorrhizal (AM) symbiosis with nutrient-acquiring fungi, aiding in the uptake of phosphate and other mineral nutrients. However, AM colonization is strongly reduced under high soil phosphate levels. A mechanistic understanding of phosphate sensing, phosphate starvation responses, and their connection to AM remains enigmatic. Here, we show that in Lotus japonicus , low-abundant, energy-rich inositol pyrophosphates act as master regulators of AM, orchestrating the crosstalk between phosphate starvation responses and plant root endosymbiosis. These findings hold promise for breeding nutrient-efficient crops.

Related

  1. Scale matters: the arbuscular mycorrhiza - root hair trade-off from individual plants to communities
    E. Matthus, J. Hennecke, K. M. Barfuss +3
    bioRxivPreprintCC BY-NC-NDFull textEcologybioRxiv
  2. Mycorrhiza, water stress, and rootstock–scion combinations shape plant physiological traits and gene expression in grapevine
    Antoine Sportès, Pauline Bruyant, Célien Durney +5
    Plant stressPeer-reviewedCC BY 4.0Full text1 citedPlant biologyHAL
  3. Deciphering the functional roles of glutaredoxin 1 in chub mackerel (Scomber japonicus): implications for antioxidant defense and immune responses
    W.P.S.N. Wijeweera, Jeganathan Tharshan Jeyakanesh, D.M.K.P. Sirisena +6
    Comparative Immunology ReportsPeer-reviewedCC BY-NCFull textImmunologyEurope PMC
  4. Interactions Between Mycorrhizal Fungi and Mycorrhiza Helper Bacteria: Mechanisms, Ecological Functions, and Potential Applications in Sustainable Agriculture and Ecological Restoration
    Shuo Guan, 邵显会, Rui Liu +3
    SustainabilityPeer-reviewedCC BY5 citedPlant biologyOpenAlex
  5. Tandem duplication has enabled functional differentiation in an olfactory gene cluster of Anastatus japonicus
    Hai-Xia Zhan, Rui Tang, Guy Smagghe +2
    Communications BiologyPeer-reviewedCC BYFull textNeuroscienceDOAJ

Cite

BibTeXRIS
BibTeX
@article{raj2026lotus,
  title = {{Lotus japonicus VIH2 is an inositol pyrophosphate synthase that regulates arbuscular mycorrhiza}},
  author = {Kiran Raj and Verena Gaugler and Mengsi Lu and Maren Schädel and Philipp Gaugler and Charlotte M. M. Grothaus and Ulrike A. Jochimsen and Athanasios Makris and Simon M. Bartsch and Anna M. Frentzen and Guizhen Liu and Michael Harings and Dorothea Fiedler and Henning Jacob Jessen and Gabriel Schaaf and Martina Katharina Ried},
  journal = {Science Advances},
  year = {2026},
  month = may,
  doi = {10.1126/sciadv.aec5607},
  url = {https://doi.org/10.1126/sciadv.aec5607},
  note = {CC BY},
}
RIS
TY  - JOUR
TI  - Lotus japonicus VIH2 is an inositol pyrophosphate synthase that regulates arbuscular mycorrhiza
AU  - Kiran Raj
AU  - Verena Gaugler
AU  - Mengsi Lu
AU  - Maren Schädel
AU  - Philipp Gaugler
AU  - Charlotte M. M. Grothaus
AU  - Ulrike A. Jochimsen
AU  - Athanasios Makris
AU  - Simon M. Bartsch
AU  - Anna M. Frentzen
AU  - Guizhen Liu
AU  - Michael Harings
AU  - Dorothea Fiedler
AU  - Henning Jacob Jessen
AU  - Gabriel Schaaf
AU  - Martina Katharina Ried
PY  - 2026
DA  - 2026/05/22
JO  - Science Advances
DO  - 10.1126/sciadv.aec5607
UR  - https://doi.org/10.1126/sciadv.aec5607
AB  - Plant yield is often maximized by the extensive use of mineral fertilizers, which, however, has severe environmental consequences. Phosphate is particularly problematic, as it represents a globally limited resource, and its runoff and soil erosion threaten open water bodies. Many crops engage in arbuscular mycorrhizal (AM) symbiosis with nutrient-acquiring fungi, aiding in the uptake of phosphate and other mineral nutrients. However, AM colonization is strongly reduced under high soil phosphate levels. A mechanistic understanding of phosphate sensing, phosphate starvation responses, and their connection to AM remains enigmatic. Here, we show that in Lotus japonicus , low-abundant, energy-rich inositol pyrophosphates act as master regulators of AM, orchestrating the crosstalk between phosphate starvation responses and plant root endosymbiosis. These findings hold promise for breeding nutrient-efficient crops.
SN  - 2375-2548
ER  -