Maternal Serum Alamandine Levels in Preeclampsia: Association with Clinical Parameters
5 affiliations
- 1Department of Obstetrics and Gynecology, Bahcelievler Medipol University Hospital, Istanbul Medipol University, İstanbul 34197, Türkiye
- 2Department of Obstetrics and Gynecology, Academic Hospital, İstanbul 34758, Türkiye
- 3Department of Internal Medicine, Bagcilar Training and Research Hospital, İstanbul 34200, Türkiye
- 4Department of Obstetrics and Gynecology, Umraniye Training and Research Hospital, İstanbul 34773, Türkiye
- 5Department of Obstetrics and Gynecology, Hekimhan State Hospital, Malatya 44410, Türkiye
Abstract
Objectives: Preeclampsia is a gestational disorder characterized by endothelial dysfunction and renin-angiotensin system imbalance. Alamandine, a component of its protective pathways, has vasodilatory effects. This study aims to compare maternal serum alamandine levels between preeclamptic and normotensive pregnancies and evaluate their associations with clinical and laboratory parameters. Methods: This prospective observational case–control study included 40 women with preeclampsia and 47 normotensive women with singleton pregnancies in the third trimester between June and December 2025. Maternal serum alamandine levels were measured using the ELISA method. Participants’ demographic, clinical, laboratory, umbilical artery Doppler, and perinatal data were prospectively recorded. Alamandine levels were compared between groups; their associations with clinical and laboratory parameters were evaluated using correlation and regression analyses. Results: Maternal serum alamandine levels were significantly lower in women with preeclampsia compared to normotensive controls (151.0 ± 51.2 vs. 174.0 ± 39.5 pg/mL; p = 0.019). However, the between-group difference was no longer statistically significant after adjustment for maternal age, body mass index, umbilical artery S/D ratio, and aspirin use (B [control − preeclampsia] = 24.76 pg/mL; 95% CI: −3.45 to 52.97; p = 0.085). Serum alamandine concentrations showed weak inverse correlations with systolic and diastolic blood pressure. A weak inverse correlation was also observed with the spot urine protein-to-creatinine ratio; however, this association did not remain statistically significant after correction for multiple comparisons. In the multivariate analysis, diastolic blood pressure and the umbilical artery S/D ratio were independently associated with maternal serum alamandine levels. Conclusions: Maternal serum alamandine levels were lower in women with preeclampsia in the unadjusted analysis; however, this difference was not statistically significant after expanded multivariable adjustment. Alamandine concentrations showed associations with selected hemodynamic parameters, whereas the relationship with proteinuria remained uncertain. These findings suggest a potential role of circulating alamandine in the vascular alterations associated with preeclampsia; however, its predictive or prognostic value cannot be determined from the present study.
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BibTeX
@article{topcu2026maternal,
title = {{Maternal Serum Alamandine Levels in Preeclampsia: Association with Clinical Parameters}},
author = {Güneş Topçu and Pınar Yıldız and Seda Şenkardeş Kandemir and Zeynep Gökçe and Gözde Konak and İbrahim Kale and Asiye Uzun},
journal = {Journal of Clinical Medicine},
year = {2026},
month = oct,
doi = {10.3390/jcm15218238},
url = {https://www.mdpi.com/2077-0383/15/21/8238},
note = {CC BY 4.0},
}
RIS
TY - JOUR
TI - Maternal Serum Alamandine Levels in Preeclampsia: Association with Clinical Parameters
AU - Güneş Topçu
AU - Pınar Yıldız
AU - Seda Şenkardeş Kandemir
AU - Zeynep Gökçe
AU - Gözde Konak
AU - İbrahim Kale
AU - Asiye Uzun
PY - 2026
DA - 2026/10/22
JO - Journal of Clinical Medicine
DO - 10.3390/jcm15218238
UR - https://www.mdpi.com/2077-0383/15/21/8238
AB - Objectives: Preeclampsia is a gestational disorder characterized by endothelial dysfunction and renin-angiotensin system imbalance. Alamandine, a component of its protective pathways, has vasodilatory effects. This study aims to compare maternal serum alamandine levels between preeclamptic and normotensive pregnancies and evaluate their associations with clinical and laboratory parameters. Methods: This prospective observational case–control study included 40 women with preeclampsia and 47 normotensive women with singleton pregnancies in the third trimester between June and December 2025. Maternal serum alamandine levels were measured using the ELISA method. Participants’ demographic, clinical, laboratory, umbilical artery Doppler, and perinatal data were prospectively recorded. Alamandine levels were compared between groups; their associations with clinical and laboratory parameters were evaluated using correlation and regression analyses. Results: Maternal serum alamandine levels were significantly lower in women with preeclampsia compared to normotensive controls (151.0 ± 51.2 vs. 174.0 ± 39.5 pg/mL; p = 0.019). However, the between-group difference was no longer statistically significant after adjustment for maternal age, body mass index, umbilical artery S/D ratio, and aspirin use (B [control − preeclampsia] = 24.76 pg/mL; 95% CI: −3.45 to 52.97; p = 0.085). Serum alamandine concentrations showed weak inverse correlations with systolic and diastolic blood pressure. A weak inverse correlation was also observed with the spot urine protein-to-creatinine ratio; however, this association did not remain statistically significant after correction for multiple comparisons. In the multivariate analysis, diastolic blood pressure and the umbilical artery S/D ratio were independently associated with maternal serum alamandine levels. Conclusions: Maternal serum alamandine levels were lower in women with preeclampsia in the unadjusted analysis; however, this difference was not statistically significant after expanded multivariable adjustment. Alamandine concentrations showed associations with selected hemodynamic parameters, whereas the relationship with proteinuria remained uncertain. These findings suggest a potential role of circulating alamandine in the vascular alterations associated with preeclampsia; however, its predictive or prognostic value cannot be determined from the present study.
SN - 2077-0383
ER -