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Peer-reviewedCC BY 4.0Frontiers in Oncology

Case Report: Early-onset Luminal B-like male breast cancer with perineural invasion

  • Limin Fan1
  • Lin Tan1
  • Wu Tang1
  1. 1Department of General Surgery, Guangzhou Twelfth People’s Hospital
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Abstract

Male breast cancer (MBC) is a rare malignancy accounting for less than 1% of all breast cancers and less than 1% of cancers in men. Compared with female breast cancer, MBC is characterized by a predominance of hormone receptor-positive luminal tumors, whereas evidence guiding individualized management remains largely extrapolated from female populations. Perineural invasion (PNI), a recognized adverse prognostic factor in several solid tumors, is uncommon in breast cancer and has rarely been reported in men. Its clinicopathological significance and therapeutic implications in male breast cancer remain poorly defined. We report a young man with stage IA Luminal B-like (HER2-negative) MBC complicated by PNI to highlight the challenges of postoperative risk stratification and adjuvant treatment decision-making.

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Cite

BibTeXRIS
BibTeX
@article{fan2026case,
  title = {{Case Report: Early-onset Luminal B-like male breast cancer with perineural invasion}},
  author = {Limin Fan and Lin Tan and Wu Tang},
  journal = {Frontiers in Oncology},
  year = {2026},
  month = oct,
  doi = {10.3389/fonc.2026.1968604},
  url = {https://www.frontiersin.org/articles/10.3389/fonc.2026.1968604/full},
  note = {CC BY 4.0},
}
RIS
TY  - JOUR
TI  - Case Report: Early-onset Luminal B-like male breast cancer with perineural invasion
AU  - Limin Fan
AU  - Lin Tan
AU  - Wu Tang
PY  - 2026
DA  - 2026/10/13
JO  - Frontiers in Oncology
DO  - 10.3389/fonc.2026.1968604
UR  - https://www.frontiersin.org/articles/10.3389/fonc.2026.1968604/full
AB  - Male breast cancer (MBC) is a rare malignancy accounting for less than 1% of all breast cancers and less than 1% of cancers in men. Compared with female breast cancer, MBC is characterized by a predominance of hormone receptor-positive luminal tumors, whereas evidence guiding individualized management remains largely extrapolated from female populations. Perineural invasion (PNI), a recognized adverse prognostic factor in several solid tumors, is uncommon in breast cancer and has rarely been reported in men. Its clinicopathological significance and therapeutic implications in male breast cancer remain poorly defined. We report a young man with stage IA Luminal B-like (HER2-negative) MBC complicated by PNI to highlight the challenges of postoperative risk stratification and adjuvant treatment decision-making.
SN  - 2234-943X
ER  -