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Peer-reviewedCC BY 4.0International Journal of Molecular Sciences

Comprehensive Genomic Profiling of Relapsed Interdigitating Dendritic Cell Sarcoma Reveals Novel Molecular Insights in a Patient Achieving Durable Remission After Autologous Stem Cell Transplantation

  • Costantino Riemma1
  • Chiara Cavatorta2
  • Chiara Salvesi3
  • Jessica Garbetta3
  • Davide Angeli4
  • Eugenio Fonzi4
  • Federico Lo Schiavo3
  • Chiara Molinari3
  • Giorgia Simonetti3
  • Francesco Malaspina1
  • Jessica Rosa1
  • Gerardo Musuraca1
1 more authors
  • Anna Ferrari3
4 affiliations
  1. 1Hematology Unit, IRCCS Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST) “Dino Amadori”, 47014 Meldola, FC, Italy
  2. 2Pathology Unit, “Maurizio Bufalini” Hospital, 47521 Cesena, FC, Italy
  3. 3Biosciences Laboratory, IRCCS Istituto Romagnolo per lo Studio dei Tumori (IRST) “Dino Amadori”, 47014 Meldola, FC, Italy
  4. 4Unit of Biostatistics and Clinical Trials, IRCCS Istituto Romagnolo per lo Studio dei Tumori (IRST) “Dino Amadori”, 47014 Meldola, FC, Italy
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Abstract

Interdigitating dendritic cell sarcoma (IDCS) is an extremely rare hematologic malignancy with no standardised therapeutic approach, particularly in the relapsed setting. We report a case of a 69-year-old woman with multifocal relapsed IDCS, KRAS/BRAF/SMARCA4 mutated, successfully treated with CHOP chemotherapy followed by consolidation with high-dose chemotherapy and autologous stem cell transplantation (ASCT), achieving a durable complete remission. This case supports the potential role of intensive chemotherapy and ASCT in selected patients with aggressive or relapsed disease.

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Cite

BibTeXRIS
BibTeX
@article{riemma2026comprehensive,
  title = {{Comprehensive Genomic Profiling of Relapsed Interdigitating Dendritic Cell Sarcoma Reveals Novel Molecular Insights in a Patient Achieving Durable Remission After Autologous Stem Cell Transplantation}},
  author = {Costantino Riemma and Chiara Cavatorta and Chiara Salvesi and Jessica Garbetta and Davide Angeli and Eugenio Fonzi and Federico Lo Schiavo and Chiara Molinari and Giorgia Simonetti and Francesco Malaspina and Jessica Rosa and Gerardo Musuraca and Anna Ferrari},
  journal = {International Journal of Molecular Sciences},
  year = {2026},
  month = oct,
  doi = {10.3390/ijms27219474},
  url = {https://www.mdpi.com/1422-0067/27/21/9474},
  note = {CC BY 4.0},
}
RIS
TY  - JOUR
TI  - Comprehensive Genomic Profiling of Relapsed Interdigitating Dendritic Cell Sarcoma Reveals Novel Molecular Insights in a Patient Achieving Durable Remission After Autologous Stem Cell Transplantation
AU  - Costantino Riemma
AU  - Chiara Cavatorta
AU  - Chiara Salvesi
AU  - Jessica Garbetta
AU  - Davide Angeli
AU  - Eugenio Fonzi
AU  - Federico Lo Schiavo
AU  - Chiara Molinari
AU  - Giorgia Simonetti
AU  - Francesco Malaspina
AU  - Jessica Rosa
AU  - Gerardo Musuraca
AU  - Anna Ferrari
PY  - 2026
DA  - 2026/10/23
JO  - International Journal of Molecular Sciences
DO  - 10.3390/ijms27219474
UR  - https://www.mdpi.com/1422-0067/27/21/9474
AB  - Interdigitating dendritic cell sarcoma (IDCS) is an extremely rare hematologic malignancy with no standardised therapeutic approach, particularly in the relapsed setting. We report a case of a 69-year-old woman with multifocal relapsed IDCS, KRAS/BRAF/SMARCA4 mutated, successfully treated with CHOP chemotherapy followed by consolidation with high-dose chemotherapy and autologous stem cell transplantation (ASCT), achieving a durable complete remission. This case supports the potential role of intensive chemotherapy and ASCT in selected patients with aggressive or relapsed disease.
SN  - 1422-0067
ER  -