Unexpected Cardiotocographic Deterioration in Fetal Transient Abnormal Myelopoiesis.
- 1Department of Obstetrics and Gynecology, Faculty of Life Science, Kumamoto University, Kumamoto, JPN.
- 2Division of Obstetrics and Gynecology, Fukuda Hospital, Kumamoto, JPN.
- 3Department of Obstetrics and Gynecology, Hyogo Medical University, Nishinomiya, JPN.
Abstract
Fetal transient abnormal myelopoiesis (TAM) can rarely occur without prenatal ultrasonographic abnormalities. We describe a case in which fetal compromise was first detected by cardiotocography (CTG). A previously uncomplicated pregnancy showed normal fetal growth and no structural abnormalities on serial ultrasonography. At 38+1 weeks of gestation, CTG revealed markedly reduced baseline variability with recurrent late decelerations, prompting emergency cesarean delivery. The male neonate, who had features of trisomy 21, exhibited marked leukocytosis with circulating blasts. Placental examination revealed intravascular blasts within both chorionic villous and umbilical cord vessels, confirming fetal TAM. Although peripheral blasts initially regressed, acute megakaryoblastic leukemia developed during infancy and required chemotherapy. Fetal TAM may occur without characteristic prenatal sonographic findings, and sudden CTG deterioration may be the first sign of fetal compromise. Placental and umbilical cord pathology can provide crucial postnatal evidence of in utero hematologic disease.
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BibTeX
@article{tanaka2026unexpected,
title = {{Unexpected Cardiotocographic Deterioration in Fetal Transient Abnormal Myelopoiesis.}},
author = {Kiyoshi Tanaka and Munekage Yamaguchi and Jun Sakata and Takeshi Motohara and Eiji Kondoh},
journal = {Cureus},
year = {2026},
month = sep,
doi = {10.7759/cureus.116943},
url = {https://europepmc.org/article/MED/42928959},
note = {CC BY},
}
RIS
TY - JOUR
TI - Unexpected Cardiotocographic Deterioration in Fetal Transient Abnormal Myelopoiesis.
AU - Kiyoshi Tanaka
AU - Munekage Yamaguchi
AU - Jun Sakata
AU - Takeshi Motohara
AU - Eiji Kondoh
PY - 2026
DA - 2026/09/25
JO - Cureus
DO - 10.7759/cureus.116943
UR - https://europepmc.org/article/MED/42928959
AB - Fetal transient abnormal myelopoiesis (TAM) can rarely occur without prenatal ultrasonographic abnormalities. We describe a case in which fetal compromise was first detected by cardiotocography (CTG). A previously uncomplicated pregnancy showed normal fetal growth and no structural abnormalities on serial ultrasonography. At 38+1 weeks of gestation, CTG revealed markedly reduced baseline variability with recurrent late decelerations, prompting emergency cesarean delivery. The male neonate, who had features of trisomy 21, exhibited marked leukocytosis with circulating blasts. Placental examination revealed intravascular blasts within both chorionic villous and umbilical cord vessels, confirming fetal TAM. Although peripheral blasts initially regressed, acute megakaryoblastic leukemia developed during infancy and required chemotherapy. Fetal TAM may occur without characteristic prenatal sonographic findings, and sudden CTG deterioration may be the first sign of fetal compromise. Placental and umbilical cord pathology can provide crucial postnatal evidence of in utero hematologic disease.
SN - 2168-8184
ER -