Association between preoperative hemoglobin, albumin, lymphocyte, and platelet (HALP) score and stricture recurrence after urethroplasty
- 1Department of Urology, Ankara Etlik City Hospital, 06170 Ankara, Turkey
- 2Department of Urology, Etimesgut State Hospital, Republic of Turkey Ministry of Health, 06790 Ankara, Turkey
- 3Department of Urology, Ankara Bilkent City Hospital, 06800 Ankara, Turkey
Abstract
Background: Recurrence after urethroplasty remains a challenging treatment issue, and there is a lack of validated preoperative biomarkers for risk classification. Although the hemoglobin, albumin, lymphocyte, and platelet (HALP) score serves as a composite marker of systemic inflammation and nutritional status, its association with urethroplasty results has not been explored. This study aimed to evaluate the association between the preoperative HALP score and stricture recurrence after urethroplasty. Methods: This retrospective cohort study included 91 male patients who underwent urethroplasty for urethral stricture disease at a tertiary referral center between January 2018 and December 2024. Preoperative HALP scores were calculated using routine laboratory parameters. Patients were classified into recurrence and recurrence-free groups based on postoperative follow-up. Univariable and multivariable logistic regression analyses were performed. The discriminatory performance of the HALP score was assessed using receiver operating characteristic (ROC) curve analysis. Results: During a median follow-up of 18 months, 17 patients (18.7%) experienced stricture recurrence. Patients with recurrence had significantly lower preoperative HALP scores compared with those without recurrence (34.8 vs. 48.9, p = 0.003). In multivariable logistic regression analysis adjusted for stricture length and history of prior urethral intervention, the HALP score remained independently associated with stricture recurrence (adjusted odds ratio (OR) 0.95, 95% confidence interval (CI): 0.91–0.99; p = 0.012). ROC analysis demonstrated moderate discriminatory ability of the HALP score for predicting recurrence (area under the curve (AUC) = 0.73). Conclusions: The preoperative HALP score was independently associated with stricture recurrence and may serve as a useful adjunct to conventional clinical risk factors; however, larger multicenter prospective studies are required before routine clinical implementation.
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BibTeX
@article{dogan2026association,
title = {{Association between preoperative hemoglobin, albumin, lymphocyte, and platelet (HALP) score and stricture recurrence after urethroplasty}},
author = {Ahmet Emin Dogan and Adem Sanci and Mehmet Altan and Gorkem Ozenc and Muhammed Yusuf Aydin and Arif Huseynli and Fatih Sandikci and Turker Soydas},
journal = {Journal of Men's Health},
year = {2026},
month = sep,
doi = {10.22514/jomh.2026.075},
url = {https://doi.org/10.22514/jomh.2026.075},
note = {CC BY},
}
RIS
TY - JOUR
TI - Association between preoperative hemoglobin, albumin, lymphocyte, and platelet (HALP) score and stricture recurrence after urethroplasty
AU - Ahmet Emin Dogan
AU - Adem Sanci
AU - Mehmet Altan
AU - Gorkem Ozenc
AU - Muhammed Yusuf Aydin
AU - Arif Huseynli
AU - Fatih Sandikci
AU - Turker Soydas
PY - 2026
DA - 2026/09/01
JO - Journal of Men's Health
DO - 10.22514/jomh.2026.075
UR - https://doi.org/10.22514/jomh.2026.075
AB - Background: Recurrence after urethroplasty remains a challenging treatment issue, and there is a lack of validated preoperative biomarkers for risk classification. Although the hemoglobin, albumin, lymphocyte, and platelet (HALP) score serves as a composite marker of systemic inflammation and nutritional status, its association with urethroplasty results has not been explored. This study aimed to evaluate the association between the preoperative HALP score and stricture recurrence after urethroplasty. Methods: This retrospective cohort study included 91 male patients who underwent urethroplasty for urethral stricture disease at a tertiary referral center between January 2018 and December 2024. Preoperative HALP scores were calculated using routine laboratory parameters. Patients were classified into recurrence and recurrence-free groups based on postoperative follow-up. Univariable and multivariable logistic regression analyses were performed. The discriminatory performance of the HALP score was assessed using receiver operating characteristic (ROC) curve analysis. Results: During a median follow-up of 18 months, 17 patients (18.7%) experienced stricture recurrence. Patients with recurrence had significantly lower preoperative HALP scores compared with those without recurrence (34.8 vs. 48.9, p = 0.003). In multivariable logistic regression analysis adjusted for stricture length and history of prior urethral intervention, the HALP score remained independently associated with stricture recurrence (adjusted odds ratio (OR) 0.95, 95% confidence interval (CI): 0.91–0.99; p = 0.012). ROC analysis demonstrated moderate discriminatory ability of the HALP score for predicting recurrence (area under the curve (AUC) = 0.73). Conclusions: The preoperative HALP score was independently associated with stricture recurrence and may serve as a useful adjunct to conventional clinical risk factors; however, larger multicenter prospective studies are required before routine clinical implementation.
SN - 1875-6867
SN - 1875-6859
ER -