3D articular knee shape drives increased anterior cruciate ligament (ACL) loading in young, active individuals with ACL injury and females
Abstract
Background: ACL rupture is a common, debilitating injury in young, active individuals. Some individuals sustain ACL injury while others do not, despite similar activity exposure. Young, active females have more than twice the ACL injury risk of males. Interactions among the knee’s complex three-dimensional (3D) articular shapes may govern how multiplanar loads implicated in noncontact ACL injury are transmitted across the joint and routed through the ACL. However, whether the 3D knee shape–ACL loading relationship explains ACL injury susceptibility and sex-disparity in risk remains unknown.
Methods: We integrated a high throughput, subject-specific, physics-based modeling framework with a cohort of 168 young, active individuals, including equal numbers with and without acute ACL injury. We isolated 3D knee shape’s contribution to ACL loading using a standardized loading condition reflecting the clinical pivot shift examination, with ligament properties held constant across individuals.
Results: We show that 3D knee shape drives increased ACL force in ACL-injured individuals within each sex and in females compared to males. These differences are amplified after scaling ACL force by ACL cross-sectional area. Coupled internal tibial rotation mediates increased ACL loading in both sexes, and anterior tibial translation contributes additionally in females.
Conclusions: These findings identify that 3D knee shape drives ACL loading through coupled motions, providing mechanistic insight into ACL injury susceptibility and sex disparity in risk. This work establishes a foundation for incorporating subject-specific knee shape into emerging digital twin approaches for individualized knee mechanics assessments, risk stratification, injury prevention, and personalized ACL surgeries and rehabilitation.
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BibTeX
@article{pechstein2026articular,
title = {{3D articular knee shape drives increased anterior cruciate ligament (ACL) loading in young, active individuals with ACL injury and females}},
author = {Andrew E. Pechstein and Mitchell G. A. Wheatley and David Z. Shamritsky and Isabella Gomez Hjerthen and Reza Pourmodheji and Jacob Zeitlin and Jacob M. Hirth and Erin E. Berube and Swithin S. Razu and Hamidreza Jahandar and Joseph E. Manzi and Brian J. Frondorf and Junsung Kim and Mark J. Amirtharaj and Michael K. Parides and Danyal H. Nawabi and Thomas L. Wickiewicz and Andrew D. Pearle and Bruce D. Beynnon and Carl W. Imhauser},
journal = {Communications Medicine},
year = {2026},
month = oct,
doi = {10.1038/s43856-026-01932-9},
url = {https://www.nature.com/articles/s43856-026-01932-9},
note = {CC BY 4.0},
}
RIS
TY - JOUR
TI - 3D articular knee shape drives increased anterior cruciate ligament (ACL) loading in young, active individuals with ACL injury and females
AU - Andrew E. Pechstein
AU - Mitchell G. A. Wheatley
AU - David Z. Shamritsky
AU - Isabella Gomez Hjerthen
AU - Reza Pourmodheji
AU - Jacob Zeitlin
AU - Jacob M. Hirth
AU - Erin E. Berube
AU - Swithin S. Razu
AU - Hamidreza Jahandar
AU - Joseph E. Manzi
AU - Brian J. Frondorf
AU - Junsung Kim
AU - Mark J. Amirtharaj
AU - Michael K. Parides
AU - Danyal H. Nawabi
AU - Thomas L. Wickiewicz
AU - Andrew D. Pearle
AU - Bruce D. Beynnon
AU - Carl W. Imhauser
PY - 2026
DA - 2026/10/07
JO - Communications Medicine
DO - 10.1038/s43856-026-01932-9
UR - https://www.nature.com/articles/s43856-026-01932-9
AB - Background: ACL rupture is a common, debilitating injury in young, active individuals. Some individuals sustain ACL injury while others do not, despite similar activity exposure. Young, active females have more than twice the ACL injury risk of males. Interactions among the knee’s complex three-dimensional (3D) articular shapes may govern how multiplanar loads implicated in noncontact ACL injury are transmitted across the joint and routed through the ACL. However, whether the 3D knee shape–ACL loading relationship explains ACL injury susceptibility and sex-disparity in risk remains unknown. Methods: We integrated a high throughput, subject-specific, physics-based modeling framework with a cohort of 168 young, active individuals, including equal numbers with and without acute ACL injury. We isolated 3D knee shape’s contribution to ACL loading using a standardized loading condition reflecting the clinical pivot shift examination, with ligament properties held constant across individuals. Results: We show that 3D knee shape drives increased ACL force in ACL-injured individuals within each sex and in females compared to males. These differences are amplified after scaling ACL force by ACL cross-sectional area. Coupled internal tibial rotation mediates increased ACL loading in both sexes, and anterior tibial translation contributes additionally in females. Conclusions: These findings identify that 3D knee shape drives ACL loading through coupled motions, providing mechanistic insight into ACL injury susceptibility and sex disparity in risk. This work establishes a foundation for incorporating subject-specific knee shape into emerging digital twin approaches for individualized knee mechanics assessments, risk stratification, injury prevention, and personalized ACL surgeries and rehabilitation.
SN - 2730-664X
ER -