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Peer-reviewedCC BYJHLT open

Preliminary experience with controlled hypothermic storage of donor heart in combined heart transplantation.

  • Salem T Argaw1
  • Lorenzo Lora Ronco2
  • Anouk Frering1
  • Martin Kloeckner3
  • Guillaume Coutance2
  • Audrey Coilly4
  • Eric Vibert4
  • Renaud Snanoudj5
  • Thibaut Genty6
  • Paul Achouh2
  • Emre Belli7
  • Julien Guihaire1,3,8
8 affiliations
  1. 1Adult Cardiac Surgery and Transplantation, Marie Lannelongue Hospital, Groupe Hospitalier Paris Saint Joseph, Le Plessis Robinson, France.
  2. 2Adult Cardiac Surgery and Transplantation, Hôpital Européen Georges-Pompidou, Paris, France.
  3. 3Department of Adult Cardiac Disease, Marie Lannelongue Hospital, Groupe Hospitalier Paris Saint Joseph, Le Plessis Robinson, France.
  4. 4Hepatobiliary Centre, Paul-Brousse Hospital, AP-HP, Paris-Saclay University, INSERM U1193, Villejuif, France.
  5. 5Nephrology-Dialysis-Transplantation, Bicêtre Hospital, AP-HP, LeKremlin-Bicêtre, France; INSERM U1184, Le Kremlin-Bicêtre, France.
  6. 6Adult Intensive Care Unit, Marie Lannelongue Hospital, Groupe Hospitalier Paris Saint Joseph, Le Plessis Robinson, France.
  7. 7Congenital Cardiac Surgery and Transplantation, Marie Lannelongue Hospital, Groupe Hospitalier Paris Saint Joseph, Le Plessis Robinson, France.
  8. 8Inserm UMR_S1358, Medical School, University of Paris Saclay, Le Kremlin Bicêtre, France.
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Abstract

While studies have demonstrated improved clinical outcomes with the use of controlled hypothermic storage (CHS) devices in isolated heart transplantation, it has not been evaluated in combined heart transplantation. In this small retrospective study (n=17), we evaluate clinical outcomes after combined heart-liver and heart-kidney transplantation in recipients of donor hearts preserved with conventional ice cold storage (ICS, n=10) versus CHS (n=7). The study found severe early graft dysfunction (EGD) occurred more frequently in the ICS cohort when compared to the CHS cohort (70% vs 0%, respectively). In addition, the CHS cohort had shorter median intensive care unit length of stay (7 days compared to 15.5 days, respectively) as well as fewer post-transplant complications, including sepsis (60% in ICS and 28.6% in CHS), pneumonia (40% in ICS and 14.3% in CHS), stroke (30% in ICS and 0% in CHS), and acute kidney injury requiring dialysis (60% in ICS and 28.6% in CHS). These preliminary findings suggest CHS may improve outcomes in combined heart transplantation.

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Cite

BibTeXRIS
BibTeX
@article{argaw2026preliminary,
  title = {{Preliminary experience with controlled hypothermic storage of donor heart in combined heart transplantation.}},
  author = {Salem T Argaw and Lorenzo Lora Ronco and Anouk Frering and Martin Kloeckner and Guillaume Coutance and Audrey Coilly and Eric Vibert and Renaud Snanoudj and Thibaut Genty and Paul Achouh and Emre Belli and Julien Guihaire},
  journal = {JHLT open},
  year = {2026},
  month = oct,
  doi = {10.1016/j.jhlto.2026.100707},
  url = {https://europepmc.org/article/MED/42999535},
  note = {CC BY},
}
RIS
TY  - JOUR
TI  - Preliminary experience with controlled hypothermic storage of donor heart in combined heart transplantation.
AU  - Salem T Argaw
AU  - Lorenzo Lora Ronco
AU  - Anouk Frering
AU  - Martin Kloeckner
AU  - Guillaume Coutance
AU  - Audrey Coilly
AU  - Eric Vibert
AU  - Renaud Snanoudj
AU  - Thibaut Genty
AU  - Paul Achouh
AU  - Emre Belli
AU  - Julien Guihaire
PY  - 2026
DA  - 2026/10/14
JO  - JHLT open
DO  - 10.1016/j.jhlto.2026.100707
UR  - https://europepmc.org/article/MED/42999535
AB  - While studies have demonstrated improved clinical outcomes with the use of controlled hypothermic storage (CHS) devices in isolated heart transplantation, it has not been evaluated in combined heart transplantation. In this small retrospective study (n=17), we evaluate clinical outcomes after combined heart-liver and heart-kidney transplantation in recipients of donor hearts preserved with conventional ice cold storage (ICS, n=10) versus CHS (n=7). The study found severe early graft dysfunction (EGD) occurred more frequently in the ICS cohort when compared to the CHS cohort (70% vs 0%, respectively). In addition, the CHS cohort had shorter median intensive care unit length of stay (7 days compared to 15.5 days, respectively) as well as fewer post-transplant complications, including sepsis (60% in ICS and 28.6% in CHS), pneumonia (40% in ICS and 14.3% in CHS), stroke (30% in ICS and 0% in CHS), and acute kidney injury requiring dialysis (60% in ICS and 28.6% in CHS). These preliminary findings suggest CHS may improve outcomes in combined heart transplantation.
SN  - 2950-1334
ER  -