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Peer-reviewedCC BY 4.0Cancers

Treatment Strategies and Future Directions for Locally Advanced Pancreatic Cancer

  • Kevin M. Turner1
  • Jason B. Gurewitz2
  • Jessica M. Frakes2
  • Jason W. Denbo1
  • Mokenge P. Malafa1
  • Pamela J. Hodul1
  • Dae Won Kim3
  • Andrew J. Sinnamon1
  1. 1Department of Gastrointestinal Surgical Oncology and Gastroenterology, H. Lee Moffitt Cancer Center & Research Institute, 12902 USF Magnolia Drive, Tampa, FL 33612, USA
  2. 2Department of Radiation Oncology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL 33612, USA
  3. 3Department of Gastrointestinal Medical Oncology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL 33612, USA
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Abstract

Locally advanced pancreatic cancer is a complex clinical entity, combining a locally aggressive tumor in a disease marked by systemic failure. Accordingly, systemic therapy upfront is recommended, with translation of recent advances in the metastatic setting promising to revolutionize the care of locally advanced disease in the future. In those patients where systemic disease remains controlled, locoregional therapies including surgery and radiation may play a role. Specific considerations of these therapies are presented in a disease phenotype marked by invasion into surrounding vasculature/luminal organs. Ongoing investigations are set to define the role of novel therapies in locally advanced disease, some of which have already gained approval. With recent advances in the control of systemic disease, locally advanced disease represents a prime target for study and treatment optimization to improve outcomes for patients.

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Cite

BibTeXRIS
BibTeX
@article{turner2026treatment,
  title = {{Treatment Strategies and Future Directions for Locally Advanced Pancreatic Cancer}},
  author = {Kevin M. Turner and Jason B. Gurewitz and Jessica M. Frakes and Jason W. Denbo and Mokenge P. Malafa and Pamela J. Hodul and Dae Won Kim and Andrew J. Sinnamon},
  journal = {Cancers},
  year = {2026},
  month = nov,
  doi = {10.3390/cancers18213520},
  url = {https://www.mdpi.com/2072-6694/18/21/3520},
  note = {CC BY 4.0},
}
RIS
TY  - JOUR
TI  - Treatment Strategies and Future Directions for Locally Advanced Pancreatic Cancer
AU  - Kevin M. Turner
AU  - Jason B. Gurewitz
AU  - Jessica M. Frakes
AU  - Jason W. Denbo
AU  - Mokenge P. Malafa
AU  - Pamela J. Hodul
AU  - Dae Won Kim
AU  - Andrew J. Sinnamon
PY  - 2026
DA  - 2026/11/02
JO  - Cancers
DO  - 10.3390/cancers18213520
UR  - https://www.mdpi.com/2072-6694/18/21/3520
AB  - Locally advanced pancreatic cancer is a complex clinical entity, combining a locally aggressive tumor in a disease marked by systemic failure. Accordingly, systemic therapy upfront is recommended, with translation of recent advances in the metastatic setting promising to revolutionize the care of locally advanced disease in the future. In those patients where systemic disease remains controlled, locoregional therapies including surgery and radiation may play a role. Specific considerations of these therapies are presented in a disease phenotype marked by invasion into surrounding vasculature/luminal organs. Ongoing investigations are set to define the role of novel therapies in locally advanced disease, some of which have already gained approval. With recent advances in the control of systemic disease, locally advanced disease represents a prime target for study and treatment optimization to improve outcomes for patients.
SN  - 2072-6694
ER  -