Electrochemically Supported Asymmetric Synthesis on Chiral Encoded Pt and Pt-Ir Surfaces.
4 affiliations
- 1School of Energy Science and Engineering, Vidyasirimedhi Institute of Science and Technology, Rayong21210, Thailand.
- 2Department of Industrial Chemistry, Faculty of Science, Chiang Mai University, Chiang Mai50200, Thailand.
- 3Department of Chemistry, Faculty of Science and Technology, Thammasat University, Pathum Thani12120, Thailand.
- 4University of Bordeaux, CNRS, Bordeaux INP, ISM, UMR 5255, 16 Avenue Pey Berland, Pessac33607, France.
Abstract
In recent years, we studied the design of chiral-encoded metal surfaces via electrodeposition as a platform for heterogeneous asymmetric synthesis, where stereochemical information is intrinsically embedded within metallic architectures together with mesoporous structures. By using lyotropic liquid crystal templating and chiral molecular imprinting, it is possible to elaborate chiral-encoded mesoporous metal electrodes by electrodeposition, particularly Pt or Pt-Ir systems, with chiral recognition sites that enable ligand-free enantioselective transformations. These designer materials exhibit high surface area, efficient mass transport, and structural robustness, overcoming key limitations of traditional enantioselective catalysis such as poor recyclability and limited stability. Our studies demonstrate that the chiral interfaces enable highly enantioselective electrosynthesis of chiral compounds, achieving up to 95% ee with excellent durability. In addition, we implemented several concepts to enhance the enantiomeric excess, for example, pulsed electrosynthesis, and self-assembled monolayer protection of chiral-imprinted metal surfaces for highly enantioselective electrosynthesis. Furthermore, we also extended the concept to heterogeneous catalysis for asymmetric synthesis of chiral molecules, in particular, pharmaceutically relevant compounds, eventually achieving up to 95% ee with excellent durability and compatibility with flow-based systems. We also integrated these materials into autonomous systems, developing chiral metal microswimmers that combine self-propulsion with enantioselective catalysis, thus enabling self-mixing. Despite ongoing challenges in stabilizing the imprinted chiral information, the broadening of this concept to other metals, such as multimetallic and non-noble systems, offers promising solutions. Taken together, these advancements establish this approach to create chiral-encoded metal surfaces as a versatile concept for the next generation of chiral-imprinted metals for sustainable asymmetric synthesis.
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BibTeX
@article{sohail2026electrochemically,
title = {{Electrochemically Supported Asymmetric Synthesis on Chiral Encoded Pt and Pt-Ir Surfaces.}},
author = {Anousha Sohail and Wanmai Srisuwanno and Sopon Butcha and Alexander Kuhn and Chularat Wattanakit},
journal = {Accounts of chemical research},
year = {2026},
month = oct,
doi = {10.1021/acs.accounts.6c00499},
url = {https://europepmc.org/article/MED/42899566},
note = {CC BY},
}
RIS
TY - JOUR
TI - Electrochemically Supported Asymmetric Synthesis on Chiral Encoded Pt and Pt-Ir Surfaces.
AU - Anousha Sohail
AU - Wanmai Srisuwanno
AU - Sopon Butcha
AU - Alexander Kuhn
AU - Chularat Wattanakit
PY - 2026
DA - 2026/10/01
JO - Accounts of chemical research
DO - 10.1021/acs.accounts.6c00499
UR - https://europepmc.org/article/MED/42899566
AB - In recent years, we studied the design of chiral-encoded metal surfaces via electrodeposition as a platform for heterogeneous asymmetric synthesis, where stereochemical information is intrinsically embedded within metallic architectures together with mesoporous structures. By using lyotropic liquid crystal templating and chiral molecular imprinting, it is possible to elaborate chiral-encoded mesoporous metal electrodes by electrodeposition, particularly Pt or Pt-Ir systems, with chiral recognition sites that enable ligand-free enantioselective transformations. These designer materials exhibit high surface area, efficient mass transport, and structural robustness, overcoming key limitations of traditional enantioselective catalysis such as poor recyclability and limited stability. Our studies demonstrate that the chiral interfaces enable highly enantioselective electrosynthesis of chiral compounds, achieving up to 95% ee with excellent durability. In addition, we implemented several concepts to enhance the enantiomeric excess, for example, pulsed electrosynthesis, and self-assembled monolayer protection of chiral-imprinted metal surfaces for highly enantioselective electrosynthesis. Furthermore, we also extended the concept to heterogeneous catalysis for asymmetric synthesis of chiral molecules, in particular, pharmaceutically relevant compounds, eventually achieving up to 95% ee with excellent durability and compatibility with flow-based systems. We also integrated these materials into autonomous systems, developing chiral metal microswimmers that combine self-propulsion with enantioselective catalysis, thus enabling self-mixing. Despite ongoing challenges in stabilizing the imprinted chiral information, the broadening of this concept to other metals, such as multimetallic and non-noble systems, offers promising solutions. Taken together, these advancements establish this approach to create chiral-encoded metal surfaces as a versatile concept for the next generation of chiral-imprinted metals for sustainable asymmetric synthesis.
SN - 0001-4842
SN - 1520-4898
ER -