The rise of fungal G-protein coupled receptors in pathogenesis and symbiosis
Abstract
G-protein coupled receptors (GPCRs) are key regulators in coordinating environmental sensing with intracellular responses.While their roles in signaling and development are well understood in mammals, fungal GPCRs remain largely unexplored.Key information on receptor classification, ligand activation, and G-protein interactions is still limited.However, recent advances in combining genomics, metagenomics, and synthetic biology with structural biology-especially structure prediction and cryo-electron microscopy (cryo-EM) -are opening new avenues for studying fungal GPCRs.In this review, we highlight recent discoveries on how GPCRs mediate fungal interactions, explore their potential roles in complex microbial communities, and suggest future research directions in this emerging field.
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BibTeX
@article{heinen2026rise,
title = {{The rise of fungal G-protein coupled receptors in pathogenesis and symbiosis}},
author = {Max Heinen and Hanna Rovenich and Florian Altegoer},
journal = {PLoS Pathogens},
year = {2026},
month = oct,
doi = {10.1371/journal.ppat.1013212},
url = {https://hal.science/hal-05780516v1},
note = {CC BY},
}
RIS
TY - JOUR
TI - The rise of fungal G-protein coupled receptors in pathogenesis and symbiosis
AU - Max Heinen
AU - Hanna Rovenich
AU - Florian Altegoer
PY - 2026
DA - 2026/10/06
JO - PLoS Pathogens
DO - 10.1371/journal.ppat.1013212
UR - https://hal.science/hal-05780516v1
AB - G-protein coupled receptors (GPCRs) are key regulators in coordinating environmental sensing with intracellular responses.While their roles in signaling and development are well understood in mammals, fungal GPCRs remain largely unexplored.Key information on receptor classification, ligand activation, and G-protein interactions is still limited.However, recent advances in combining genomics, metagenomics, and synthetic biology with structural biology-especially structure prediction and cryo-electron microscopy (cryo-EM) -are opening new avenues for studying fungal GPCRs.In this review, we highlight recent discoveries on how GPCRs mediate fungal interactions, explore their potential roles in complex microbial communities, and suggest future research directions in this emerging field.
SN - 1553-7366
SN - 1553-7374
ER -