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Peer-reviewedCC BYPLoS Genetics

Genomic Data Reveal a Complex Making of Humans

  • Isabel Alves
  • Anna Šrámková Hanulová
  • Matthieu Foll
  • Laurent Excoffier
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Abstract

In the last few years, two paradigms underlying human evolution have crumbled. Modern humans have not totally replaced previous hominins without any admixture, and the expected signatures of adaptations to new environments are surprisingly lacking at the genomic level. Here we review current evidence about archaic admixture and lack of strong selective sweeps in humans. We underline the need to properly model differential admixture in various populations to correctly reconstruct past demography. We also stress the importance of taking into account the spatial dimension of human evolution, which proceeded by a series of range expansions that could have promoted both the introgression of archaic genes and background selection.

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Cite

BibTeXRIS
BibTeX
@article{alves2026genomic,
  title = {{Genomic Data Reveal a Complex Making of Humans}},
  author = {Isabel Alves and Anna Šrámková Hanulová and Matthieu Foll and Laurent Excoffier},
  journal = {PLoS Genetics},
  year = {2026},
  month = oct,
  doi = {10.1371/journal.pgen.1002837},
  url = {https://hal.science/hal-05842815v1},
  note = {CC BY},
}
RIS
TY  - JOUR
TI  - Genomic Data Reveal a Complex Making of Humans
AU  - Isabel Alves
AU  - Anna Šrámková Hanulová
AU  - Matthieu Foll
AU  - Laurent Excoffier
PY  - 2026
DA  - 2026/10/28
JO  - PLoS Genetics
DO  - 10.1371/journal.pgen.1002837
UR  - https://hal.science/hal-05842815v1
AB  - In the last few years, two paradigms underlying human evolution have crumbled. Modern humans have not totally replaced previous hominins without any admixture, and the expected signatures of adaptations to new environments are surprisingly lacking at the genomic level. Here we review current evidence about archaic admixture and lack of strong selective sweeps in humans. We underline the need to properly model differential admixture in various populations to correctly reconstruct past demography. We also stress the importance of taking into account the spatial dimension of human evolution, which proceeded by a series of range expansions that could have promoted both the introgression of archaic genes and background selection.
SN  - 1553-7390
SN  - 1553-7404
ER  -