Case Report: Brucella-associated complications following thoracic endovascular aortic repair: a case series of three patients
7 affiliations
- 1Jiuquan Hospital of Shanghai General Hospital (Jiuquan People's Hospital)
- 2Department of Vascular Surgery, General Surgery, The First Hospital of Lanzhou University
- 3The First Clinical Medical School, Lanzhou University
- 4Heart Center, The First Hospital of Lanzhou University
- 5Gansu Provincial Clinical Research Center for Cardiovascular Diseases, The First Hospital of Lanzhou University
- 6School of Clinical Medicine, Tsinghua University
- 7Vascular Department, Beijing Hua Xin Hospital (1st Hospital of Tsinghua University)
Abstract
Background: Brucellosis is a rare but potentially fatal cause of vascular graft infection. Evidence regarding Brucella-associated complications after thoracic endovascular aortic repair (TEVAR) remains limited. Case presentation: We report three elderly male patients who developed severe aortic complications following TEVAR, including pseudoaneurysm formation and aorto-esophageal fistula. All patients had a history of epidemiological exposure to Brucella and were diagnosed with active infection through serological testing (Rose Bengal test, serum agglutination test, Brucella IgG and IgM antibodies). Endovascular re-intervention combined with targeted anti-brucellosis therapy was performed in all cases.
Results: One patient achieved sustained clinical remission after repeat endovascular repair and prolonged antimicrobial therapy. Two patients developed catastrophic infectious complications, including mediastinal abscess and aorto-esophageal fistula, resulting in death despite aggressive management.
Conclusions: Brucella infection should be considered in patients presenting with unexplained symptoms after TEVAR, especially in endemic regions. Endovascular repair plays a critical role in acute stabilization; however, long-term outcomes remain highly dependent on effective infection control.
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BibTeX
@article{jing2026case,
title = {{Case Report: Brucella-associated complications following thoracic endovascular aortic repair: a case series of three patients}},
author = {Lei Jing and Linhai Li and Dan Zhou and Weijian Chen and Yonglong Wang and Linguang Han and Chenghui Wang and Xiaojun Shu and Lei Li and Yingxin Tan},
journal = {Frontiers in Cardiovascular Medicine},
year = {2026},
month = oct,
doi = {10.3389/fcvm.2026.1885416},
url = {https://www.frontiersin.org/articles/10.3389/fcvm.2026.1885416/full},
note = {CC BY 4.0},
}
RIS
TY - JOUR
TI - Case Report: Brucella-associated complications following thoracic endovascular aortic repair: a case series of three patients
AU - Lei Jing
AU - Linhai Li
AU - Dan Zhou
AU - Weijian Chen
AU - Yonglong Wang
AU - Linguang Han
AU - Chenghui Wang
AU - Xiaojun Shu
AU - Lei Li
AU - Yingxin Tan
PY - 2026
DA - 2026/10/15
JO - Frontiers in Cardiovascular Medicine
DO - 10.3389/fcvm.2026.1885416
UR - https://www.frontiersin.org/articles/10.3389/fcvm.2026.1885416/full
AB - Background: Brucellosis is a rare but potentially fatal cause of vascular graft infection. Evidence regarding Brucella-associated complications after thoracic endovascular aortic repair (TEVAR) remains limited. Case presentation: We report three elderly male patients who developed severe aortic complications following TEVAR, including pseudoaneurysm formation and aorto-esophageal fistula. All patients had a history of epidemiological exposure to Brucella and were diagnosed with active infection through serological testing (Rose Bengal test, serum agglutination test, Brucella IgG and IgM antibodies). Endovascular re-intervention combined with targeted anti-brucellosis therapy was performed in all cases. Results: One patient achieved sustained clinical remission after repeat endovascular repair and prolonged antimicrobial therapy. Two patients developed catastrophic infectious complications, including mediastinal abscess and aorto-esophageal fistula, resulting in death despite aggressive management. Conclusions: Brucella infection should be considered in patients presenting with unexplained symptoms after TEVAR, especially in endemic regions. Endovascular repair plays a critical role in acute stabilization; however, long-term outcomes remain highly dependent on effective infection control.
SN - 2297-055X
ER -