A novel adomavirus from proliferative skin lesions of a broadnose sevengill shark (Notorynchus cepedianus)
10 affiliations
- 1Hubbard Center for Genome Studies, Department of Molecular, Cellular, and Biomedical Sciences, University of New Hampshire, Durham, NH USA
- 2Laboratory of Cellular Oncology, National Cancer Institute, National Institutes of Health, Bethesda, MD USA
- 3Monterey Bay Aquarium, Monterey, CA USA
- 4New Hampshire Veterinary Diagnostic Laboratory, University of New Hampshire, Durham, NH USA
- 5ZooQuatic Laboratory, LLC, Baltimore, MD USA
- 6Department of Pathology and Laboratory Medicine, Dartmouth Hitchcock Medical Center, Lebanon, NH USA
- 7Geisel School of Medicine at Dartmouth, Hanover, NH USA
- 8Department of Pathology, University of Texas Medical Branch, Galveston, TX USA
- 9Washington Animal Disease Diagnostic Laboratory, Department of Veterinary Microbiology and Pathology, College of Veterinary Medicine, Washington State University, Pullman, WA USA
- 10Department of Pathobiology and Veterinary Science, University of Connecticut, Storrs, CT USA
Abstract
In May of 2022, an aquarium-maintained broadnose sevengill shark (Notorynchus cepedianus) developed proliferative skin lesions that prompted pathologic and molecular investigation. Histopathologic examination revealed epidermal hyperplasia consisting of proliferation of spinous epithelial cells with mild dysplasia. Metagenomic sequencing identified a novel adomavirus with an 18,834 base pair circular double-stranded DNA genome. The virus, provisionally named broadnose sevengill shark adomavirus (7AdoV), contains two bidirectionally expressed protein-coding gene sets. Genomic annotation and structural predictions of proteins were used to contextualize 7AdoV phylogenetically and functionally. Transcriptomic analysis showed that expression of the structural late gene set was higher than the replicative early gene set at the time of diagnostic sampling. In situ hybridization using RNAscope technology localized transcripts of the adomavirus Wasp gene to epithelial cells of the hyperplastic epidermis. Infection by this novel adomavirus was associated with superficial and proliferative lesions that were self-limiting and resolved in this shark.
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BibTeX
@article{gordon2026novel,
title = {{A novel adomavirus from proliferative skin lesions of a broadnose sevengill shark (Notorynchus cepedianus)}},
author = {Lawrence M. Gordon and Joseph L. Sevigny and Christopher B. Buck and Michael J. Murray and Inga F. Sidor and Alisa L. Newton and Scott M. Palisoul and Muriel Kelly and Adane S. Nigatu and Stephen D. Simpson and Vsevolod L. Popov and Thomas B. Waltzek and Gregory J. Tsongalis and Salvatore Frasca and W. Kelley Thomas},
journal = {npj Viruses},
year = {2026},
month = jul,
doi = {10.1038/s44298-026-00210-8},
url = {https://doi.org/10.1038/s44298-026-00210-8},
note = {CC BY 4.0},
}
RIS
TY - JOUR
TI - A novel adomavirus from proliferative skin lesions of a broadnose sevengill shark (Notorynchus cepedianus)
AU - Lawrence M. Gordon
AU - Joseph L. Sevigny
AU - Christopher B. Buck
AU - Michael J. Murray
AU - Inga F. Sidor
AU - Alisa L. Newton
AU - Scott M. Palisoul
AU - Muriel Kelly
AU - Adane S. Nigatu
AU - Stephen D. Simpson
AU - Vsevolod L. Popov
AU - Thomas B. Waltzek
AU - Gregory J. Tsongalis
AU - Salvatore Frasca
AU - W. Kelley Thomas
PY - 2026
DA - 2026/07/01
JO - npj Viruses
DO - 10.1038/s44298-026-00210-8
UR - https://doi.org/10.1038/s44298-026-00210-8
AB - In May of 2022, an aquarium-maintained broadnose sevengill shark (Notorynchus cepedianus) developed proliferative skin lesions that prompted pathologic and molecular investigation. Histopathologic examination revealed epidermal hyperplasia consisting of proliferation of spinous epithelial cells with mild dysplasia. Metagenomic sequencing identified a novel adomavirus with an 18,834 base pair circular double-stranded DNA genome. The virus, provisionally named broadnose sevengill shark adomavirus (7AdoV), contains two bidirectionally expressed protein-coding gene sets. Genomic annotation and structural predictions of proteins were used to contextualize 7AdoV phylogenetically and functionally. Transcriptomic analysis showed that expression of the structural late gene set was higher than the replicative early gene set at the time of diagnostic sampling. In situ hybridization using RNAscope technology localized transcripts of the adomavirus Wasp gene to epithelial cells of the hyperplastic epidermis. Infection by this novel adomavirus was associated with superficial and proliferative lesions that were self-limiting and resolved in this shark.
SN - 2948-1767
ER -