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Peer-reviewedCC BY-NC-ND 4.0Poultry Science

Effects of chlorogenic acid on production performance, antioxidant capacity and intestinal microbiota of quails exposed to cold stress

  • Chunhua Wang1,2
  • Hongxin Sun2
  • Guoxu Liang3
  • Tian Tian2
  • Yong Liu4
  • Fanbo Zeng2
  • Xingru Wang2
  • Baoming Shi1
4 affiliations
  1. 1College of Animal Science and Technology, Northeast Agricultural University, Harbin, 150030, China
  2. 2College of Life Science and Technology, Mudanjiang Normal University, Mudanjiang, 157011, China
  3. 3College of Life Science and Technology, Harbin Normal University, Harbin, 150006, China
  4. 4School of Basic Medical Sciences, Mudanjiang Medical University, Mudanjiang, 157011, China
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Abstract

Cold stress adversely impairs productive performance, disrupts lipid metabolism, and breaks intestinal microecological homeostasis in poultry. Chlorogenic acid (CGA) exhibits multiple biological properties, including anti-inflammatory, antioxidant, and metabolic regulatory activities. This study aimed to investigate the effects of dietary CGA supplementation on laying performance, egg quality, lipid metabolism, antioxidant activity, and intestinal microbial composition in cold-stressed laying quails. A total of 144 high-yield laying quails (210-day-old) were randomly divided into 4 groups with 6 replicates each (n = 6/replicate). The control group (CON) and cold stress group (MOD) received a basal diet. The low-dose CGA group (LDG) and high-dose CGA group (HDG) received a basal diet supplemented with 100 mg/kg and 200 mg/kg CGA, respectively, for 1 week before cold stress exposure. Quails in the MOD, LDG, and HDG groups were exposed to 5°C for 10 h while the CON group was maintained at 24°C. The results demonstrated that dietary CGA supplementation significantly reversed the cold stress-induced decline in laying rate, and improved the yolk index and Haugh unit compared with the MOD group. Meanwhile, CGA treatment increased the activities of CAT, SOD, and GSH-Px, and reduced the contents of MDA, T-CHO, and TG. Furthermore, dietary CGA supplementation raised the relative abundance of beneficial bacteria (e.g., Bacteroidetes) and lowered that of potential pathogenic bacteria (e.g., Enterococcus). Network pharmacology and molecular docking analyses predicted that CGA could interact with several potential target proteins, including DBT, BCKDHA, ALDH18A1, DLD, HSPE1, FH, YARS1, and CLPP. In conclusion, dietary CGA supplementation could alleviate cold stress-induced physiological damage in laying quails by improving lipid metabolism, enhancing antioxidant capacity, and modulating intestinal microbiota structure.

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Cite

BibTeXRIS
BibTeX
@article{wang2026effects,
  title = {{Effects of chlorogenic acid on production performance, antioxidant capacity and intestinal microbiota of quails exposed to cold stress}},
  author = {Chunhua Wang and Hongxin Sun and Guoxu Liang and Tian Tian and Yong Liu and Fanbo Zeng and Xingru Wang and Baoming Shi},
  journal = {Poultry Science},
  year = {2026},
  month = oct,
  doi = {10.1016/j.psj.2026.107870},
  url = {https://doi.org/10.1016/j.psj.2026.107870},
  note = {CC BY-NC-ND 4.0},
}
RIS
TY  - JOUR
TI  - Effects of chlorogenic acid on production performance, antioxidant capacity and intestinal microbiota of quails exposed to cold stress
AU  - Chunhua Wang
AU  - Hongxin Sun
AU  - Guoxu Liang
AU  - Tian Tian
AU  - Yong Liu
AU  - Fanbo Zeng
AU  - Xingru Wang
AU  - Baoming Shi
PY  - 2026
DA  - 2026/10/05
JO  - Poultry Science
DO  - 10.1016/j.psj.2026.107870
UR  - https://doi.org/10.1016/j.psj.2026.107870
AB  - Cold stress adversely impairs productive performance, disrupts lipid metabolism, and breaks intestinal microecological homeostasis in poultry. Chlorogenic acid (CGA) exhibits multiple biological properties, including anti-inflammatory, antioxidant, and metabolic regulatory activities. This study aimed to investigate the effects of dietary CGA supplementation on laying performance, egg quality, lipid metabolism, antioxidant activity, and intestinal microbial composition in cold-stressed laying quails. A total of 144 high-yield laying quails (210-day-old) were randomly divided into 4 groups with 6 replicates each (n = 6/replicate). The control group (CON) and cold stress group (MOD) received a basal diet. The low-dose CGA group (LDG) and high-dose CGA group (HDG) received a basal diet supplemented with 100 mg/kg and 200 mg/kg CGA, respectively, for 1 week before cold stress exposure. Quails in the MOD, LDG, and HDG groups were exposed to 5°C for 10 h while the CON group was maintained at 24°C. The results demonstrated that dietary CGA supplementation significantly reversed the cold stress-induced decline in laying rate, and improved the yolk index and Haugh unit compared with the MOD group. Meanwhile, CGA treatment increased the activities of CAT, SOD, and GSH-Px, and reduced the contents of MDA, T-CHO, and TG. Furthermore, dietary CGA supplementation raised the relative abundance of beneficial bacteria (e.g., Bacteroidetes) and lowered that of potential pathogenic bacteria (e.g., Enterococcus). Network pharmacology and molecular docking analyses predicted that CGA could interact with several potential target proteins, including DBT, BCKDHA, ALDH18A1, DLD, HSPE1, FH, YARS1, and CLPP. In conclusion, dietary CGA supplementation could alleviate cold stress-induced physiological damage in laying quails by improving lipid metabolism, enhancing antioxidant capacity, and modulating intestinal microbiota structure.
SN  - 0032-5791
SN  - 1525-3171
ER  -