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Peer-reviewedCC BYSSM: Qualitative Research in Health

The architecture of adherence: A gender–relational analysis of men's tuberculosis treatment journeys in Eastern Cape, South Africa

5 affiliations
  1. 1Edson College of Nursing and Health Innovation, Arizona State University, Phoenix, AZ, United States; Corresponding author. Edson College of Nursing and Health Innovation, Arizona State University, 550 N 3rd St. Phoenix, AZ, 85004, United States.
  2. 2Buffalo City Metro Health District, Eastern Cape Provincial Department of Health, East London, South Africa
  3. 3Epidemiology and Research Directorate, Eastern Cape Provincial Department of Health, Bisho, South Africa; Department of Public Health, Faculty of Medicine and Health Sciences, Walter Sisulu University, South Africa
  4. 4Foundation for Professional Development, Pretoria, South Africa
  5. 5Edson College of Nursing and Health Innovation, Arizona State University, Phoenix, AZ, United States

Abstract

Background: Men experience disproportionate delays in tuberculosis (TB) diagnosis and challenges in adherence to treatment in part due to gender norms and social perceptions that illness and help-seeking by men are forms of weakness and vulnerability. This study explored how men with TB navigate treatment adherence within a gender-relational context, with particular attention to how masculinity is negotiated through caregiving relationships. Methods: A secondary qualitative analysis was conducted using de-identified, semi-structured interviews with 30 men who were undergoing or had recently completed TB treatment in Eastern Cape, South Africa. Guided by Courtenay's Theory of Gender and Health, a reflexive thematic analysis was conducted. Analysis proceeded through iterative phases of familiarization, codebook development, theory-informed categorization, thematic development and refinement, and conceptual synthesis. Results: Four interrelated themes were identified: Managing Illness Visibility and Masculine Self-Presentation ; Negotiating Help-Seeking Through Trusted Relationships ; Relational Support for Sustaining Treatment Engagement ; and R esponsibility, Protection, and the Moral Logic of Adherence . Themes were organized into a theory-informed gender–relational process illustrating how masculinity may be negotiated in the context of illness, using TB as the empirical setting. Conclusion: Men's TB treatment adherence may be best understood as a gender-relational process, embedded within a social and caregiving context. Recognizing relational conditions (i.e., women's caregiving contributions) that support men's engagement in care may inform more gender-responsive and relationally attuned approaches to supporting men when they are ill.

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BibTeX
@article{bahrami2026architecture,
  title = {{The architecture of adherence: A gender–relational analysis of men's tuberculosis treatment journeys in Eastern Cape, South Africa}},
  author = {Raheleh Bahrami and Andrew Medina-Marino and Nondumiso Ngcelwane and Singilizwe Moko and Gloria Maimela and Sarita Naidoo and Sarah Sarandos and Joseph A. Daniels},
  journal = {SSM: Qualitative Research in Health},
  year = {2026},
  month = oct,
  doi = {10.1016/j.ssmqr.2026.100890},
  url = {https://doi.org/10.1016/j.ssmqr.2026.100890},
  note = {CC BY},
}
RIS
TY  - JOUR
TI  - The architecture of adherence: A gender–relational analysis of men's tuberculosis treatment journeys in Eastern Cape, South Africa
AU  - Raheleh Bahrami
AU  - Andrew Medina-Marino
AU  - Nondumiso Ngcelwane
AU  - Singilizwe Moko
AU  - Gloria Maimela
AU  - Sarita Naidoo
AU  - Sarah Sarandos
AU  - Joseph A. Daniels
PY  - 2026
DA  - 2026/10/31
JO  - SSM: Qualitative Research in Health
DO  - 10.1016/j.ssmqr.2026.100890
UR  - https://doi.org/10.1016/j.ssmqr.2026.100890
AB  - Background: Men experience disproportionate delays in tuberculosis (TB) diagnosis and challenges in adherence to treatment in part due to gender norms and social perceptions that illness and help-seeking by men are forms of weakness and vulnerability. This study explored how men with TB navigate treatment adherence within a gender-relational context, with particular attention to how masculinity is negotiated through caregiving relationships. Methods: A secondary qualitative analysis was conducted using de-identified, semi-structured interviews with 30 men who were undergoing or had recently completed TB treatment in Eastern Cape, South Africa. Guided by Courtenay's Theory of Gender and Health, a reflexive thematic analysis was conducted. Analysis proceeded through iterative phases of familiarization, codebook development, theory-informed categorization, thematic development and refinement, and conceptual synthesis. Results: Four interrelated themes were identified: Managing Illness Visibility and Masculine Self-Presentation ; Negotiating Help-Seeking Through Trusted Relationships ; Relational Support for Sustaining Treatment Engagement ; and R esponsibility, Protection, and the Moral Logic of Adherence . Themes were organized into a theory-informed gender–relational process illustrating how masculinity may be negotiated in the context of illness, using TB as the empirical setting. Conclusion: Men's TB treatment adherence may be best understood as a gender-relational process, embedded within a social and caregiving context. Recognizing relational conditions (i.e., women's caregiving contributions) that support men's engagement in care may inform more gender-responsive and relationally attuned approaches to supporting men when they are ill.
SN  - 2667-3215
ER  -