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Peer-reviewedCC BY 4.0Cell Reports

Ataxin-2 loss flips a metabolic switch for neuron health

  • Fabiana Longo
  • Albert R. La Spada
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Abstract

Gastaldo et al. 1 report that lowering ataxin-2 protects neurons from TDP-43 toxicity in amyotrophic lateral sclerosis by activating neuronal glycolysis and astrocytic cholesterol synthesis, not by reversing TDP-43-dependent molecular pathology. The downstream effectors, IDH1 and HMGCS1, thus emerge as candidate therapeutic targets.

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Cite

BibTeXRIS
BibTeX
@article{longo2026ataxin2,
  title = {{Ataxin-2 loss flips a metabolic switch for neuron health}},
  author = {Fabiana Longo and Albert R. La Spada},
  journal = {Cell Reports},
  year = {2026},
  month = oct,
  doi = {10.1016/j.celrep.2026.118128},
  url = {https://linkinghub.elsevier.com/retrieve/pii/S2211124726012076},
  note = {CC BY 4.0},
}
RIS
TY  - JOUR
TI  - Ataxin-2 loss flips a metabolic switch for neuron health
AU  - Fabiana Longo
AU  - Albert R. La Spada
PY  - 2026
DA  - 2026/10/30
JO  - Cell Reports
DO  - 10.1016/j.celrep.2026.118128
UR  - https://linkinghub.elsevier.com/retrieve/pii/S2211124726012076
AB  - Gastaldo et al. 1 report that lowering ataxin-2 protects neurons from TDP-43 toxicity in amyotrophic lateral sclerosis by activating neuronal glycolysis and astrocytic cholesterol synthesis, not by reversing TDP-43-dependent molecular pathology. The downstream effectors, IDH1 and HMGCS1, thus emerge as candidate therapeutic targets.
SN  - 2211-1247
ER  -