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Peer-reviewedCC BYCureus

False-Negative Ligamentum Teres Tendon Sampling for the Detection of Systemic Amyloidosis.

  • Thomas R Yetter1
  • Zachary D Mendoza1,2
  • Roxanne R Miller1
  • Barry H Trachtenberg3
  • Shari R Liberman1
  1. 1Department of Orthopedics and Sports Medicine, Houston Methodist Hospital, Houston, USA.
  2. 2School of Engineering Medicine, Texas A&M University, Houston, USA.
  3. 3DeBakey Heart and Vascular Center, Houston Methodist Hospital, Houston, USA.
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Abstract

This case report involves a 60-year-old man with bilateral carpal tunnel syndrome, hip osteoarthritis, and lumbar spinal stenosis who underwent biopsies of the ligamentum teres, ligamentum flavum, and carpal flexor tenosynovium. Amyloid deposits were identified in the ligamentum flavum and flexor tenosynovium, but not the ligamentum teres. Amyloid was typed by mass spectrometry, cardiac scintigraphy was negative, and genetic testing remains pending. This supports that ligamentum flavum and carpal flexor tenosynovium biopsies may have better diagnostic value for the early diagnosis of amyloidosis, while the ligamentum teres is an unpredictable location of biopsy for early diagnosis.

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Cite

BibTeXRIS
BibTeX
@article{yetter2026falsenegative,
  title = {{False-Negative Ligamentum Teres Tendon Sampling for the Detection of Systemic Amyloidosis.}},
  author = {Thomas R Yetter and Zachary D Mendoza and Roxanne R Miller and Barry H Trachtenberg and Shari R Liberman},
  journal = {Cureus},
  year = {2026},
  month = sep,
  doi = {10.7759/cureus.116430},
  url = {https://europepmc.org/article/MED/42910238},
  note = {CC BY},
}
RIS
TY  - JOUR
TI  - False-Negative Ligamentum Teres Tendon Sampling for the Detection of Systemic Amyloidosis.
AU  - Thomas R Yetter
AU  - Zachary D Mendoza
AU  - Roxanne R Miller
AU  - Barry H Trachtenberg
AU  - Shari R Liberman
PY  - 2026
DA  - 2026/09/17
JO  - Cureus
DO  - 10.7759/cureus.116430
UR  - https://europepmc.org/article/MED/42910238
AB  - This case report involves a 60-year-old man with bilateral carpal tunnel syndrome, hip osteoarthritis, and lumbar spinal stenosis who underwent biopsies of the ligamentum teres, ligamentum flavum, and carpal flexor tenosynovium. Amyloid deposits were identified in the ligamentum flavum and flexor tenosynovium, but not the ligamentum teres. Amyloid was typed by mass spectrometry, cardiac scintigraphy was negative, and genetic testing remains pending. This supports that ligamentum flavum and carpal flexor tenosynovium biopsies may have better diagnostic value for the early diagnosis of amyloidosis, while the ligamentum teres is an unpredictable location of biopsy for early diagnosis.
SN  - 2168-8184
ER  -